This paper presents an application of finite element simulation with the analysis of arterial stiffness. The influences of the intravascular pressures on arterial wall which behaves like hyperelastic material was investigated by using Mooney-Rivlin hyperelastic constitutive model with the finite element solver of LS-DYNA. The results were obtained in the forms of nonlinear pressure-diameter relationship. Moreover, the diameter variation of arterial model corresponds to the pulsatile blood pressure. But the distensibility of artery reduces when the level of pulsatile blood pressure increases. These numerical results are expected to clarify an assessment of the arterial stiffness using photoelectric plethysmograph.