Single bovine serum albumin molecule can hold plural blue-emissive gold nanoclusters: A quantitative study with two-photon excitation

Hamza Al Kindi, Ahmed Mohamed, Shinji Kajimoto, Nurbosyn Zhanpeisov, Hideyuki Horino, Yutaka Shibata, Izabela Irena Rzeznicka, Hiroshi Fukumura

Research output: Contribution to journalArticle

8 Citations (Scopus)


Two-photon luminescence properties of gold nanoclusters (Au8NCs) encapsulated in bovine serum albumin (BSA) were investigated. A new synthesis protocol is reported to control the number of Au8 clusters in one BSA. Both one- and two-photon excitation of BSA with multiple Au8NCs gave an identical blue luminescence. The two-photon absorption (TPA) cross-section value for BSA with one Au8NCs was obtained to be 190 GM (Goeppert-Mayer) and 540 GM for BSA with three Au8NCs, at 740 nm excitation wavelength. This study shows that BSA with multiple Au8NCs may be used as a biocompatible luminescence probe for two-photon in-vivo imaging.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalJournal of Photochemistry and Photobiology A: Chemistry
Publication statusPublished - 2018 Apr 15



  • Au8 nanocluster
  • Blue emission
  • Bovine serum albumin
  • In-vivo imaging
  • Two-photon absorption
  • Two-photon emission cross-section

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Physics and Astronomy(all)

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