Single cell surgery with monodispersed microbubbles generated by a pulsed discharge of microelectric knife

Hiroki Kuriki, Yoko Yamanishi, Shinya Sakuma, Satoshi Akagi, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have successfully operated enucleation of oocyte by using microelectric knife without any thermal collateral damage. Minimally-invasive cellular-scale ablation was achieved by the mono-dispersed microbubbles which were generated by a pulse discharge of microelectrode. The discharged output power and conductive area of microelectrode were controlled by glass shell insulation around the copper microwire. A small space which is called "bubble reservoir" between the wire and glass tip contributes to stabilize the electric discharge and directional bubble generation.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages183-185
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

Keywords

  • Electrically-induced
  • Enucleation
  • Micro-nano bubble

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Kuriki, H., Yamanishi, Y., Sakuma, S., Akagi, S., & Arai, F. (2012). Single cell surgery with monodispersed microbubbles generated by a pulsed discharge of microelectric knife. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 183-185). (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012). Chemical and Biological Microsystems Society.