Size-dependent filtration and trapping of microparticle in a microfluidic chip using centrifugal force and a graduated mechanical gap

Hisataka Maruyama, Shinya Sakuma, Yoko Yamanishi, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We proposed size-dependent microparticle filtration and particle trap by centrifugal force and mechanical restriction using three-dimensional magnetically driven microtool (3D-MMT) in a microfluidic chip. Novelties of this paper are summarized as follows. (1) Filtration of particles is robust against pressure fluctuation in microchannels rather than using only hydrodynamic force because particles are separated mechanically, (2) Clogging of the microparticles could be avoided by rotation of the 3D-MMT in a mcirochamber, (3) Size-classified microparticles can be trapped along the gaps in microchannels by flow control. Microparticles having different sizes flow in spiral microchannels and filtered according to their sizes by gaps between gaps and substrate by centrifugal force. Microparticles larger than the gap cannot pass through the gap and are kept flowing in the inner microchannel. Rotation of the 3D-MMT by magnetic force from an external magnetic circuit generates swirling flow in the microchamber. Size-classified microparticles can be trapped in microchannel by closing the drain port of the target particle. Trapped particles can be measured by direct observation and treated by reagent. After the experiment, trapped particles are extracted by open the drain ports. We successfully demonstrated microparticle filtration and microparticle trap of filtered particles in the developed microfluidic chip.

Original languageEnglish
Title of host publication2009 IEEE/SICE International Symposium on System Integration
Subtitle of host publicationSI International 2008 - The 2nd Symposium on System Integration
Pages7-12
Number of pages6
DOIs
Publication statusPublished - 2009
Event2nd International Symposium on System Integration, SII 2009 - Tokyo, Japan
Duration: 2009 Nov 292009 Nov 29

Publication series

Name2009 IEEE/SICE International Symposium on System Integration: SI International 2008 - The 2nd Symposium on System Integration

Conference

Conference2nd International Symposium on System Integration, SII 2009
CountryJapan
CityTokyo
Period09/11/2909/11/29

Keywords

  • Filtration
  • Magnetically driven microtool
  • Mechanical gap
  • Microparticles
  • Trap

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computational Theory and Mathematics

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    Maruyama, H., Sakuma, S., Yamanishi, Y., & Arai, F. (2009). Size-dependent filtration and trapping of microparticle in a microfluidic chip using centrifugal force and a graduated mechanical gap. In 2009 IEEE/SICE International Symposium on System Integration: SI International 2008 - The 2nd Symposium on System Integration (pp. 7-12). [5384565] (2009 IEEE/SICE International Symposium on System Integration: SI International 2008 - The 2nd Symposium on System Integration). https://doi.org/10.1109/SI.2009.5384565