Abstract
We reviewed the fundamental aspects and applications of slide-ring materials as new polymeric materials for DDS. The slide-ring gel is one of the slide-ring materials using sliding features most effectively and has movable cross-linking junctions. As a result, it exhibited mechanical properties quite different from chemical gels, rather close to biomaterials. The small angle neutron scattering studies of the slide-ring gels revealed that the pulley effect relaxed the inhomogeneous structure in the slide-ring gels. In addition, we introduced the sol-gel transition of methylated polyrotaxane as a new thermoreversible DDS system. Finally, we discussed the application of the slide-ring materials to DDS with the future view.
| Original language | English |
|---|---|
| Pages (from-to) | 592-598 |
| Number of pages | 7 |
| Journal | Drug Delivery System |
| Volume | 21 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
Keywords
- polyrotaxane
- slide-ring gel
- thermo-reversible sol-gel transition
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Slide-ring materials : New polymeric materials for dds. / Kidowaki, Masatoshi; Ito, Kohzo; Kataoka, Tohiyuki; Kidowaki, Masatoshi; Ito, Kohzo.
In: Drug Delivery System, Vol. 21, No. 6, 2006, p. 592-598.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Slide-ring materials
T2 - New polymeric materials for dds
AU - Kidowaki, Masatoshi
AU - Ito, Kohzo
AU - Kataoka, Tohiyuki
AU - Kidowaki, Masatoshi
AU - Ito, Kohzo
PY - 2006
Y1 - 2006
N2 - We reviewed the fundamental aspects and applications of slide-ring materials as new polymeric materials for DDS. The slide-ring gel is one of the slide-ring materials using sliding features most effectively and has movable cross-linking junctions. As a result, it exhibited mechanical properties quite different from chemical gels, rather close to biomaterials. The small angle neutron scattering studies of the slide-ring gels revealed that the pulley effect relaxed the inhomogeneous structure in the slide-ring gels. In addition, we introduced the sol-gel transition of methylated polyrotaxane as a new thermoreversible DDS system. Finally, we discussed the application of the slide-ring materials to DDS with the future view.
AB - We reviewed the fundamental aspects and applications of slide-ring materials as new polymeric materials for DDS. The slide-ring gel is one of the slide-ring materials using sliding features most effectively and has movable cross-linking junctions. As a result, it exhibited mechanical properties quite different from chemical gels, rather close to biomaterials. The small angle neutron scattering studies of the slide-ring gels revealed that the pulley effect relaxed the inhomogeneous structure in the slide-ring gels. In addition, we introduced the sol-gel transition of methylated polyrotaxane as a new thermoreversible DDS system. Finally, we discussed the application of the slide-ring materials to DDS with the future view.
KW - polyrotaxane
KW - slide-ring gel
KW - thermo-reversible sol-gel transition
UR - http://www.scopus.com/inward/record.url?scp=48949092158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48949092158&partnerID=8YFLogxK
U2 - 10.2745/dds.21.592
DO - 10.2745/dds.21.592
M3 - Article
AN - SCOPUS:48949092158
VL - 21
SP - 592
EP - 598
JO - Drug Delivery System
JF - Drug Delivery System
SN - 0913-5006
IS - 6
ER -