Slide-ring materials: New polymeric materials for dds

Masatoshi Kidowaki, Kohzo Ito, Tohiyuki Kataoka, Masatoshi Kidowaki, Kohzo Ito

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3 Citations (Scopus)

Abstract

We reviewed the fundamental aspects and applications of slide-ring materials as new polymeric materials for DDS. The slide-ring gel is one of the slide-ring materials using sliding features most effectively and has movable cross-linking junctions. As a result, it exhibited mechanical properties quite different from chemical gels, rather close to biomaterials. The small angle neutron scattering studies of the slide-ring gels revealed that the pulley effect relaxed the inhomogeneous structure in the slide-ring gels. In addition, we introduced the sol-gel transition of methylated polyrotaxane as a new thermoreversible DDS system. Finally, we discussed the application of the slide-ring materials to DDS with the future view.

Original languageEnglish
Pages (from-to)592-598
Number of pages7
JournalDrug Delivery System
Volume21
Issue number6
DOIs
Publication statusPublished - 2006 Jan 1

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Keywords

  • polyrotaxane
  • slide-ring gel
  • thermo-reversible sol-gel transition

ASJC Scopus subject areas

  • Pharmaceutical Science

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