Soft scrubbing off of zona pellucida on disposable microfluidic chip

Yoko Yamanishi; Takehito Mizunuma; Naoki Inomata; Shogo Kudo; Funihito Arai

doi:10.1109/MEMSYS.2010.5442516

Soft scrubbing off of zona pellucida on disposable microfluidic chip

Yoko Yamanishi, Takehito Mizunuma, Naoki Inomata, Shogo Kudo, Funihito Arai

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

8 Citations (Scopus)

Abstract

We succeeded in automation of removal of the zona pellucida of swine oocyte using magnetically driven microtool (MMT) in microfluidic chip. The proposed system can manipulate multiple oocytes at one time with high stability which has an strong advantages over the conventional manual manipulation of removal one by one with pipetting. We proposed the automation of removal of zona pellucida by activating soft polymeric materials in a disposable microfluidic chip to achieve mass production of manipulated embryos as well as accurate and stable manipulations. It can be a breakthrough of a high throughput of accurate and effective oocyte manipulations in the field of cloning and fertility treatment.

Original language	English
Title of host publication	MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest
Pages	256-259
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2010.5442516
Publication status	Published - 2010
Externally published	Yes
Event	23rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2010 - Hong Kong, China Duration: 2010 Jan 24 → 2010 Jan 28

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	23rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2010
Country/Territory	China
City	Hong Kong
Period	10/1/24 → 10/1/28

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

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10.1109/MEMSYS.2010.5442516

Cite this

Yamanishi, Y., Mizunuma, T., Inomata, N., Kudo, S., & Arai, F. (2010). Soft scrubbing off of zona pellucida on disposable microfluidic chip. In MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest (pp. 256-259). [5442516] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2010.5442516

Soft scrubbing off of zona pellucida on disposable microfluidic chip. / Yamanishi, Yoko; Mizunuma, Takehito; Inomata, Naoki et al.

MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest. 2010. p. 256-259 5442516 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yamanishi, Y, Mizunuma, T, Inomata, N, Kudo, S & Arai, F 2010, Soft scrubbing off of zona pellucida on disposable microfluidic chip. in MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest., 5442516, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 256-259, 23rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2010, Hong Kong, China, 10/1/24. https://doi.org/10.1109/MEMSYS.2010.5442516

Yamanishi Y, Mizunuma T, Inomata N, Kudo S, Arai F. Soft scrubbing off of zona pellucida on disposable microfluidic chip. In MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest. 2010. p. 256-259. 5442516. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2010.5442516

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abstract = "We succeeded in automation of removal of the zona pellucida of swine oocyte using magnetically driven microtool (MMT) in microfluidic chip. The proposed system can manipulate multiple oocytes at one time with high stability which has an strong advantages over the conventional manual manipulation of removal one by one with pipetting. We proposed the automation of removal of zona pellucida by activating soft polymeric materials in a disposable microfluidic chip to achieve mass production of manipulated embryos as well as accurate and stable manipulations. It can be a breakthrough of a high throughput of accurate and effective oocyte manipulations in the field of cloning and fertility treatment.",

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Soft scrubbing off of zona pellucida on disposable microfluidic chip

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