3-Trifluoromethylfuran (1) was efficiently synthesized by the reaction of 4-methyloxazole with 3, 3, 3-trifluoropropyne. Lithiation of 1 with n-butyllithium followed by reaction with an electrophile gave the corresponding 2-substituted 3-trifluoromethylfuran (4). Starting from 2-triethylsilyl-3-trifluoromethylfuran (4a), 2-substituted 4-trifluoromethylfurans (6) were synthesized.
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 1985|
KAWADA, KOSUKE., Kitagawa, O., & KOBAYASHI, YOSHIRO. (1985). Studies on Organic Fluorine Compounds. XLV. Synthesis and Regioselective Substitution Reaction of 3-Trifluoromethylfuran. Chemical and Pharmaceutical Bulletin, 33(9), 3670-3674.