The parametric stabilization of nonlinear systems with parametric uncertainty is considered in this paper by switching control strategy. First, the moving equilibrium problem for nonlinear systems with parameters variations is investigated. The existence of equilibrium involves the solution of a system of nonlinear algebraic equations. Then, by using multiple Lyapunov function, the sufficient condition of parametric stabilization for the nonlinear systems is formulated based on linear matrix inequality. Furthermore, the switching controllers are designed to be activated safely in the parametric stability region via switching logics. Furthermore, appropriate switching control law is designed to achieve the smooth switching of the nonlinear system between the parameters subsets. Finally, an example is given to illustrate the effectiveness of the proposed method.