TY - JOUR
T1 - Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
AU - Suhara, Yoshitomo
AU - Nakane, Shinji
AU - Arai, Shunsuke
AU - Takayama, Hiroaki
AU - Waku, Keizo
AU - Ishima, Yoshio
AU - Sugiura, Takayuki
N1 - Funding Information:
The authors are grateful to Junko Shimode and Maroka Kitsukawa for the spectroscopic measurements. This study was supported in part by Special Coordination Funds of the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/8/6
Y1 - 2001/8/6
N2 - Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.
AB - Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.
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U2 - 10.1016/S0960-894X(01)00350-X
DO - 10.1016/S0960-894X(01)00350-X
M3 - Article
C2 - 11454463
AN - SCOPUS:0035817227
VL - 11
SP - 1985
EP - 1988
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 15
ER -