Abstract
Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.
| Original language | English |
|---|---|
| Pages (from-to) | 1985-1988 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 11 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2001 Aug 6 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Suhara, Y., Nakane, S., Arai, S., Takayama, H., Waku, K., Ishima, Y., & Sugiura, T. (2001). Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Bioorganic and Medicinal Chemistry Letters, 11(15), 1985-1988. https://doi.org/10.1016/S0960-894X(01)00350-X