Abstract
Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.
| Original language | English |
|---|---|
| Pages (from-to) | 1985-1988 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 11 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2001 Aug 6 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. / Suhara, Yoshitomo; Nakane, Shinji; Arai, Shunsuke; Takayama, Hiroaki; Waku, Keizo; Ishima, Yoshio; Sugiura, Takayuki.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 15, 06.08.2001, p. 1985-1988.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
AU - Suhara, Yoshitomo
AU - Nakane, Shinji
AU - Arai, Shunsuke
AU - Takayama, Hiroaki
AU - Waku, Keizo
AU - Ishima, Yoshio
AU - Sugiura, Takayuki
PY - 2001/8/6
Y1 - 2001/8/6
N2 - Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.
AB - Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.
UR - http://www.scopus.com/inward/record.url?scp=0035817227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035817227&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(01)00350-X
DO - 10.1016/S0960-894X(01)00350-X
M3 - Article
C2 - 11454463
AN - SCOPUS:0035817227
VL - 11
SP - 1985
EP - 1988
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 15
ER -