Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Yoshitomo Suhara; Shinji Nakane; Shunsuke Arai; Hiroaki Takayama; Keizo Waku; Yoshio Ishima; Takayuki Sugiura

doi:10.1016/S0960-894X(01)00350-X

Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Yoshitomo Suhara, Shinji Nakane, Shunsuke Arai, Hiroaki Takayama, Keizo Waku, Yoshio Ishima, Takayuki Sugiura

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Novel analogues of 2-arachidonoylglycerol (2-AG), an endogenous cannabinoid receptor ligand, were developed. Chemical synthesis of these analogues (2-AGA105 and 2-AGA109) was accomplished starting from 2-octyn-1-ol and diethyl malonate and employing Wittig coupling of triene phosphonate with an aldehyde intermediate in a convergent and stereoselective manner. These analogues should be useful lead compounds for the development of novel 2-AG mimetics.

Original language	English
Pages (from-to)	1985-1988
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	15
DOIs	https://doi.org/10.1016/S0960-894X(01)00350-X
Publication status	Published - 2001 Aug 6
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. / Suhara, Yoshitomo; Nakane, Shinji; Arai, Shunsuke; Takayama, Hiroaki; Waku, Keizo; Ishima, Yoshio; Sugiura, Takayuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 15, 06.08.2001, p. 1985-1988.

Research output: Contribution to journal › Article › peer-review

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AU - Ishima, Yoshio

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