Synthesis and characterization of a DNA analogue stabilized by mercapto C-nucleoside induced disulfide bonding

Akihiko Hatano, Seiji Makita, Masayuki Kirihara

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A redox-active nucleobase analogue of a nucleotide was synthesized and incorporated into DNA using phosphoramidite chemistry. An analogue-containing oligonucleotide in the absence of a reducing reagent formed a stable duplex with a substantially higher melting temperature compared to that of a standard DNA duplex of the same length.

Original languageEnglish
Pages (from-to)2459-2462
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number10
DOIs
Publication statusPublished - 2004 May 17

Keywords

  • C-nucleotides
  • DNA
  • Disulfide base pair
  • Stable duplex

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis and characterization of a DNA analogue stabilized by mercapto C-nucleoside induced disulfide bonding'. Together they form a unique fingerprint.

  • Cite this