Synthesis and characterization of a DNA analogue stabilized by mercapto C-nucleoside induced disulfide bonding

Akihiko Hatano, Seiji Makita, Masayuki Kirihara

Research output: Contribution to journalArticle

16 Citations (Scopus)


A redox-active nucleobase analogue of a nucleotide was synthesized and incorporated into DNA using phosphoramidite chemistry. An analogue-containing oligonucleotide in the absence of a reducing reagent formed a stable duplex with a substantially higher melting temperature compared to that of a standard DNA duplex of the same length.

Original languageEnglish
Pages (from-to)2459-2462
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number10
Publication statusPublished - 2004 May 17
Externally publishedYes



  • C-nucleotides
  • Disulfide base pair
  • DNA
  • Stable duplex

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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