Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides

Takeo Taguchi; Osamu Kitagawa; Tsutomu Morikawa; Tohru Nishiwaki; Hideya Uehara; Hatsumi Endo; Yoshiro Kobayashi

doi:10.1016/S0040-4039(00)85409-X

Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides

Takeo Taguchi, Osamu Kitagawa, Tsutomu Morikawa, Tohru Nishiwaki, Hideya Uehara, Hatsumi Endo, Yoshiro Kobayashi

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Abstract

CC bond formation through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield. With alkenyl iodides, these reactions are stereospecific.

Original language	English
Pages (from-to)	6103-6106
Number of pages	4
Journal	Tetrahedron Letters
Volume	27
Issue number	50
DOIs	https://doi.org/10.1016/S0040-4039(00)85409-X
Publication status	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides",

abstract = "CC bond formation through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield. With alkenyl iodides, these reactions are stereospecific.",

author = "Takeo Taguchi and Osamu Kitagawa and Tsutomu Morikawa and Tohru Nishiwaki and Hideya Uehara and Hatsumi Endo and Yoshiro Kobayashi",

year = "1986",

doi = "10.1016/S0040-4039(00)85409-X",

language = "English",

volume = "27",

pages = "6103--6106",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "50",

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TY - JOUR

T1 - Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides

AU - Taguchi, Takeo

AU - Kitagawa, Osamu

AU - Morikawa, Tsutomu

AU - Nishiwaki, Tohru

AU - Uehara, Hideya

AU - Endo, Hatsumi

AU - Kobayashi, Yoshiro

PY - 1986

Y1 - 1986

N2 - CC bond formation through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield. With alkenyl iodides, these reactions are stereospecific.

AB - CC bond formation through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield. With alkenyl iodides, these reactions are stereospecific.

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U2 - 10.1016/S0040-4039(00)85409-X

DO - 10.1016/S0040-4039(00)85409-X

M3 - Article

AN - SCOPUS:0001186360

VL - 27

SP - 6103

EP - 6106

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 50

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