Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides

Takeo Taguchi, Osamu Kitagawa, Tsutomu Morikawa, Tohru Nishiwaki, Hideya Uehara, Hatsumi Endo, Yoshiro Kobayashi

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)

Abstract

CC bond formation through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield. With alkenyl iodides, these reactions are stereospecific.

Original languageEnglish
Pages (from-to)6103-6106
Number of pages4
JournalTetrahedron Letters
Volume27
Issue number50
DOIs
Publication statusPublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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