Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides

Takeo Taguchi, Osamu Kitagawa, Tsutomu Morikawa, Tohru Nishiwaki, Hideya Uehara, Hatsumi Endo, Yoshiro Kobayashi

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

CC bond formation through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield. With alkenyl iodides, these reactions are stereospecific.

Original languageEnglish
Pages (from-to)6103-6106
Number of pages4
JournalTetrahedron Letters
Volume27
Issue number50
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Taguchi, T., Kitagawa, O., Morikawa, T., Nishiwaki, T., Uehara, H., Endo, H., & Kobayashi, Y. (1986). Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides. Tetrahedron Letters, 27(50), 6103-6106. https://doi.org/10.1016/S0040-4039(00)85409-X