Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides

Takeo Taguchi, Osamu Kitagawa, Tsutomu Morikawa, Tohru Nishiwaki, Hideya Uehara, Hatsumi Endo, Yoshiro Kobayashi

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

CC bond formation through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield. With alkenyl iodides, these reactions are stereospecific.

Original languageEnglish
Pages (from-to)6103-6106
Number of pages4
JournalTetrahedron Letters
Volume27
Issue number50
DOIs
Publication statusPublished - 1986
Externally publishedYes

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Iodides
Copper

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Taguchi, T., Kitagawa, O., Morikawa, T., Nishiwaki, T., Uehara, H., Endo, H., & Kobayashi, Y. (1986). Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides. Tetrahedron Letters, 27(50), 6103-6106. https://doi.org/10.1016/S0040-4039(00)85409-X

Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides. / Taguchi, Takeo; Kitagawa, Osamu; Morikawa, Tsutomu; Nishiwaki, Tohru; Uehara, Hideya; Endo, Hatsumi; Kobayashi, Yoshiro.

In: Tetrahedron Letters, Vol. 27, No. 50, 1986, p. 6103-6106.

Research output: Contribution to journalArticle

Taguchi, T, Kitagawa, O, Morikawa, T, Nishiwaki, T, Uehara, H, Endo, H & Kobayashi, Y 1986, 'Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides', Tetrahedron Letters, vol. 27, no. 50, pp. 6103-6106. https://doi.org/10.1016/S0040-4039(00)85409-X
Taguchi, Takeo ; Kitagawa, Osamu ; Morikawa, Tsutomu ; Nishiwaki, Tohru ; Uehara, Hideya ; Endo, Hatsumi ; Kobayashi, Yoshiro. / Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides. In: Tetrahedron Letters. 1986 ; Vol. 27, No. 50. pp. 6103-6106.
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