Synthesis of aminoglycoside derivatives on a Cbz-type heavy fluorous tag

Mamoru Mizuno; Hiroharu Matsumoto; Kohtaro Goto; Keita Hamasaki

doi:10.1016/j.tetlet.2006.10.064

Synthesis of aminoglycoside derivatives on a Cbz-type heavy fluorous tag

Mamoru Mizuno, Hiroharu Matsumoto, Kohtaro Goto, Keita Hamasaki

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Four aminoglycoside derivatives containing a 2,6-diamino-2,6-dideoxy-d-glucopyranose disaccharide structure were successfully prepared by using a Cbz-type heavy fluorous tag in a fluorous synthesis. A Cbz-type heavy fluorous tag was prepared using the hexakis(fluorous chain)-type alcohol 11, and the fluorous alcohol 11 was recovered in good yield after the synthesis of aminoglycoside derivatives.

Original language	English
Pages (from-to)	8831-8835
Number of pages	5
Journal	Tetrahedron Letters
Volume	47
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2006.10.064
Publication status	Published - 2006 Dec 11

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2006.10.064

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abstract = "Four aminoglycoside derivatives containing a 2,6-diamino-2,6-dideoxy-d-glucopyranose disaccharide structure were successfully prepared by using a Cbz-type heavy fluorous tag in a fluorous synthesis. A Cbz-type heavy fluorous tag was prepared using the hexakis(fluorous chain)-type alcohol 11, and the fluorous alcohol 11 was recovered in good yield after the synthesis of aminoglycoside derivatives.",

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AU - Mizuno, Mamoru

AU - Matsumoto, Hiroharu

AU - Goto, Kohtaro

AU - Hamasaki, Keita

PY - 2006/12/11

Y1 - 2006/12/11

N2 - Four aminoglycoside derivatives containing a 2,6-diamino-2,6-dideoxy-d-glucopyranose disaccharide structure were successfully prepared by using a Cbz-type heavy fluorous tag in a fluorous synthesis. A Cbz-type heavy fluorous tag was prepared using the hexakis(fluorous chain)-type alcohol 11, and the fluorous alcohol 11 was recovered in good yield after the synthesis of aminoglycoside derivatives.

AB - Four aminoglycoside derivatives containing a 2,6-diamino-2,6-dideoxy-d-glucopyranose disaccharide structure were successfully prepared by using a Cbz-type heavy fluorous tag in a fluorous synthesis. A Cbz-type heavy fluorous tag was prepared using the hexakis(fluorous chain)-type alcohol 11, and the fluorous alcohol 11 was recovered in good yield after the synthesis of aminoglycoside derivatives.

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Synthesis of aminoglycoside derivatives on a Cbz-type heavy fluorous tag

Abstract

ASJC Scopus subject areas

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