Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimito Kimura, Yoshihisa Hirota, Shigefumi Kuwahara, Atsuko Takeuchi, Chisato Tode, Akimori Wada, Naomi Osakabe, Yoshitomo Suhara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.

Original languageEnglish
Pages (from-to)2591-2596
Number of pages6
JournalJournal of Medicinal Chemistry
Volume60
Issue number6
DOIs
Publication statusPublished - 2017 Mar 23

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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