Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Yoshitomo Suhara, Yoshihisa Hirota, Norika Hanada, Shun Nishina, Sachiko Eguchi, Rie Sakane, Kimie Nakagawa, Akimori Wada, Kazuhiko Takahashi, Hiroaki Tokiwa, Toshio Okano

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We synthesized new vitamin K<inf>2</inf> analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K<inf>2</inf>.

Original languageEnglish
Pages (from-to)7088-7092
Number of pages5
JournalJournal of Medicinal Chemistry
Volume58
Issue number17
DOIs
Publication statusPublished - 2015 Sep 10

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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