Temperature-responsiveness and sustained delivery properties of macroporous PEG-co-PNIPAAm-co-PCL hydrogels

Zhao Xia Li, Man Geng Lu, Kun Wu, Yun Fei Zhang, Lei Miao, Yin Wen Li, Hui Long Guo, Jian Zheng

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A series of novel thermosensitive macroporous poly (ethylene glycol) (PEG)-co-poly(N-isopropylacrylamide) (PNIPAAm)-co-poly (e-caprolactone) (PCL) hydrogels were synthesized via in situ free radical polymerization. Poly(ethylene glycol diacrylate) (PEGDAc) and poly(e-caprolactone diacrylate) (PCLDAc) were prepared as macrocrosslinkers. All compounds were investigated by Nuclear Magnetic Resonance (NMR) and Fourier transform-infrared spectroscopy (FT-IR). Differential Scanning Calorimetry (DSC) results showed the lower critical solution temperatures (LCSTs) of the gels were at around 31°C. The macroporous gels not only had considerable swelling ratios, but also exhibited rapid swelling kinetics and response sensitivity. Above mentioned hydrogels showed a remarkable oscillatory swelling-deswelling transition, making them have potential application in long-term drug delivery.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalPolymer Engineering and Science
Volume55
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

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