The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

Hiroaki Suzuki, Megumi Kurita, Kiyohisa Mizumoto, Masatsugu Moriyama, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuoka

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19 ARF or human p14 ARF binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume326
Issue number1
DOIs
Publication statusPublished - 2004 Dec 31
Externally publishedYes

Fingerprint

Tumors
Tumor Suppressor Protein p14ARF
Genes

Keywords

  • ARF
  • BCL6
  • p14
  • p19
  • Tumor suppressor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. / Suzuki, Hiroaki; Kurita, Megumi; Mizumoto, Kiyohisa; Moriyama, Masatsugu; Aiso, Sadakazu; Nishimoto, Ikuo; Matsuoka, Masaaki.

In: Biochemical and Biophysical Research Communications, Vol. 326, No. 1, 31.12.2004, p. 242-248.

Research output: Contribution to journalArticle

Suzuki, Hiroaki ; Kurita, Megumi ; Mizumoto, Kiyohisa ; Moriyama, Masatsugu ; Aiso, Sadakazu ; Nishimoto, Ikuo ; Matsuoka, Masaaki. / The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. In: Biochemical and Biophysical Research Communications. 2004 ; Vol. 326, No. 1. pp. 242-248.
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