The conformational and binding properties of ethylbipyridinio-modified β-Cyclodextrin using induced circular dichroism

Yi Qun Du, Asao Nakamura, Fujio Toda

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The conformational and binding properties of mono-6-deoxy-6[4-(1-ethyl-4-pyridinio)-1-pyridinio]-β-cyclodextrin (1) in complex formation with some guest compounds were examined by induced circular dichroism (ICD) spectra in aqueous solution. Compound 1 showed much stronger binding ability for some guest compounds (1: 1 complexes), compared with β-cyclodextrin (β-CDx) and a positively charged β-CDx [C-6-mono-pyridino-β-CDx (2)]. Marked conformational changes of 1 (the spatial position of the ethyl viologen (C2V2+) group relative to the cavity in 1) were observed upon complex formation with some guests like 1-adamantanecarboxylic acid (ACA) and sodium cholate (SC).

Original languageEnglish
Pages (from-to)443-451
Number of pages9
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume10
Issue number4
DOIs
Publication statusPublished - 1991 Jun
Externally publishedYes

Fingerprint

circular dichroism spectroscopy
cyclodextrins
binding properties
Cyclodextrins
dichroism
Viologens
Sodium Cholate
Dichroism
binding capacity
aqueous solutions
sodium
cavities
acids
adamantanecarboxylic acid

Keywords

  • binding ability
  • complex
  • conformation
  • Cyclodextrin
  • ethyl viologen
  • steroidal guest

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)

Cite this

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title = "The conformational and binding properties of ethylbipyridinio-modified β-Cyclodextrin using induced circular dichroism",
abstract = "The conformational and binding properties of mono-6-deoxy-6[4-(1-ethyl-4-pyridinio)-1-pyridinio]-β-cyclodextrin (1) in complex formation with some guest compounds were examined by induced circular dichroism (ICD) spectra in aqueous solution. Compound 1 showed much stronger binding ability for some guest compounds (1: 1 complexes), compared with β-cyclodextrin (β-CDx) and a positively charged β-CDx [C-6-mono-pyridino-β-CDx (2)]. Marked conformational changes of 1 (the spatial position of the ethyl viologen (C2V2+) group relative to the cavity in 1) were observed upon complex formation with some guests like 1-adamantanecarboxylic acid (ACA) and sodium cholate (SC).",
keywords = "binding ability, complex, conformation, Cyclodextrin, ethyl viologen, steroidal guest",
author = "Du, {Yi Qun} and Asao Nakamura and Fujio Toda",
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T1 - The conformational and binding properties of ethylbipyridinio-modified β-Cyclodextrin using induced circular dichroism

AU - Du, Yi Qun

AU - Nakamura, Asao

AU - Toda, Fujio

PY - 1991/6

Y1 - 1991/6

N2 - The conformational and binding properties of mono-6-deoxy-6[4-(1-ethyl-4-pyridinio)-1-pyridinio]-β-cyclodextrin (1) in complex formation with some guest compounds were examined by induced circular dichroism (ICD) spectra in aqueous solution. Compound 1 showed much stronger binding ability for some guest compounds (1: 1 complexes), compared with β-cyclodextrin (β-CDx) and a positively charged β-CDx [C-6-mono-pyridino-β-CDx (2)]. Marked conformational changes of 1 (the spatial position of the ethyl viologen (C2V2+) group relative to the cavity in 1) were observed upon complex formation with some guests like 1-adamantanecarboxylic acid (ACA) and sodium cholate (SC).

AB - The conformational and binding properties of mono-6-deoxy-6[4-(1-ethyl-4-pyridinio)-1-pyridinio]-β-cyclodextrin (1) in complex formation with some guest compounds were examined by induced circular dichroism (ICD) spectra in aqueous solution. Compound 1 showed much stronger binding ability for some guest compounds (1: 1 complexes), compared with β-cyclodextrin (β-CDx) and a positively charged β-CDx [C-6-mono-pyridino-β-CDx (2)]. Marked conformational changes of 1 (the spatial position of the ethyl viologen (C2V2+) group relative to the cavity in 1) were observed upon complex formation with some guests like 1-adamantanecarboxylic acid (ACA) and sodium cholate (SC).

KW - binding ability

KW - complex

KW - conformation

KW - Cyclodextrin

KW - ethyl viologen

KW - steroidal guest

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