The metabolism of plasma glucose and catecholamines in Alzheimer's disease

H. Umegaki, N. Tamaya, T. Shinkai, A. Iguchi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Several lines of evidence suggest that the cholinergic system in the hippocampus plays a pivotal roll in regulating the peripheral metabolism of glucose and catecholamines. The injection of cholinergic stimulators including neostigmine, the acetylcholine esterase inhibitor, into the third ventricle or the hippocampus induces the elevation of glucose or catecholamines in plasma in rats. Under stress conditions, release of acetylcholine in the hippocampus increases, which coincides with the elevation of plasma glucose and catecholamines. Age-related reduction in responsivity of the cholinergic system in the hippocampus has been well documented. The intrahippocampal neostigmine injection induces significantly attenuated responses in plasma glucose and catecholamines in rats, the finding suggested that changes in cholinergic system activity in the hippocampus could result in alteration of the peripheral metabolism of glucose and catecholamines. In Alzheimer's disease (AD), the most common type of dementia, degeneration of the hippocampal cholinergic system is one of the most robust pathological features. Measurement of plasma catecholamines during a fasting state in the groups of AD subjects, vascular dementia subjects, and non-demented control subjects showed significantly lower plasma epinephrine levels in the AD subjects. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1373-1382
Number of pages10
JournalExperimental Gerontology
Volume35
Issue number9-10
DOIs
Publication statusPublished - 2000 Dec 18

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Keywords

  • Acetylcholine
  • Aging
  • Dementia
  • Hippocampus
  • Insulin
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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