Thionation of Optically Pure N-C Axially Chiral Quinazolin-4-one Derivatives with Lawesson's Reagent

Erina Niijima, Tomomi Imai, Hayate Suzuki, Yuuki Fujimoto, Osamu Kitagawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The reaction of various optically pure N-C axially chiral quinazolin-4-one derivatives with Lawesson's reagent proceeded without a marked decrease in optical purity to give optically active quinazoline-4-thione derivatives (93-99% ee) possessing a high rotational barrier in good yields.

Original languageEnglish
Pages (from-to)709-715
Number of pages7
JournalJournal of Organic Chemistry
Volume86
Issue number1
DOIs
Publication statusPublished - 2021 Jan 1

ASJC Scopus subject areas

  • Organic Chemistry

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