Three-dimensional elemental mapping of hollow Fe 2O 3@SiO 2 mesoporous spheres using scanning confocal electron microscopy

Peng Wang, Ayako Hashimoto, Masaki Takeguchi, Kazutaka Mitsuishi, Masayuki Shimojo, Yufang Zhu, Mitsuhiro Okuda, Angus I. Kirkland, Peter D. Nellist

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Energy filtered scanning confocal electron microscopy (EFSCEM) in an aberration-corrected transmission electron microscope offers an approach for three-dimensional imaging and chemical analysis of nanoscale materials related to the well-established technique of confocal scanning optical microscopy. Here, we apply EFSCEM to the compositional analysis of the core structure in candidate structures for targeted drug delivery. Element-specific optical sectioning along the specimen depth direction demonstrates the presence of additional Si in a nominal Fe 2O 3 core. The presence of Si in the core is consistent with a specific formation mechanism for the hollow structure of the core.

Original languageEnglish
Article number213117
JournalApplied Physics Letters
Issue number21
Publication statusPublished - 2012 May 21

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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