Three-dimensional elemental mapping of hollow Fe 2O 3@SiO 2 mesoporous spheres using scanning confocal electron microscopy

Peng Wang, Ayako Hashimoto, Masaki Takeguchi, Kazutaka Mitsuishi, Masayuki Shimojo, Yufang Zhu, Mitsuhiro Okuda, Angus I. Kirkland, Peter D. Nellist

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Abstract

Energy filtered scanning confocal electron microscopy (EFSCEM) in an aberration-corrected transmission electron microscope offers an approach for three-dimensional imaging and chemical analysis of nanoscale materials related to the well-established technique of confocal scanning optical microscopy. Here, we apply EFSCEM to the compositional analysis of the core structure in candidate structures for targeted drug delivery. Element-specific optical sectioning along the specimen depth direction demonstrates the presence of additional Si in a nominal Fe 2O 3 core. The presence of Si in the core is consistent with a specific formation mechanism for the hollow structure of the core.

Original languageEnglish
Article number213117
JournalApplied Physics Letters
Volume100
Issue number21
DOIs
Publication statusPublished - 2012 May 21

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ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Wang, P., Hashimoto, A., Takeguchi, M., Mitsuishi, K., Shimojo, M., Zhu, Y., Okuda, M., Kirkland, A. I., & Nellist, P. D. (2012). Three-dimensional elemental mapping of hollow Fe 2O 3@SiO 2 mesoporous spheres using scanning confocal electron microscopy. Applied Physics Letters, 100(21), [213117]. https://doi.org/10.1063/1.4714889