THz imaging of nucleobases and cancerous tissue using a GaP THz-wave generator

Jun Ichi Nishizawa; Tetsuo Sasaki; Ken Suto; Tetsuya Yamada; Tadao Tanabe; Takenori Tanno; Takashi Sawai; Yasuhiro Miura

doi:10.1016/j.optcom.2004.09.064

THz imaging of nucleobases and cancerous tissue using a GaP THz-wave generator

Jun Ichi Nishizawa, Tetsuo Sasaki, Ken Suto, Tetsuya Yamada, Tadao Tanabe, Takenori Tanno, Takashi Sawai, Yasuhiro Miura

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

We constructed a terahertz (THz) spectroscopic imaging system using a GaP THz-wave generator with automatic scanning control, and demonstrated power-transmission imaging measurements. To characterize the system, images of polyethylene pellets containing cytosine powder at various concentrations were taken. At a resonance frequency of 2.86 THz, the imaging system detected 5000 ppm cytosine. In addition, we demonstrated that THz imaging has a possibility to distinguish regions of metastatic cancer from normal tissue in liver, by comparing a THz-wave image at 0.835 THz with that at 1.465 THz.

Original language	English
Pages (from-to)	469-474
Number of pages	6
Journal	Optics Communications
Volume	244
Issue number	1-6
DOIs	https://doi.org/10.1016/j.optcom.2004.09.064
Publication status	Published - 2005 Jan 3
Externally published	Yes

Keywords

Cancer liver
Cytosine
Frequency-tunable coherent terahertz wave
Terahertz imaging
Terahertz spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry
Electrical and Electronic Engineering

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10.1016/j.optcom.2004.09.064

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title = "THz imaging of nucleobases and cancerous tissue using a GaP THz-wave generator",

abstract = "We constructed a terahertz (THz) spectroscopic imaging system using a GaP THz-wave generator with automatic scanning control, and demonstrated power-transmission imaging measurements. To characterize the system, images of polyethylene pellets containing cytosine powder at various concentrations were taken. At a resonance frequency of 2.86 THz, the imaging system detected 5000 ppm cytosine. In addition, we demonstrated that THz imaging has a possibility to distinguish regions of metastatic cancer from normal tissue in liver, by comparing a THz-wave image at 0.835 THz with that at 1.465 THz.",

keywords = "Cancer liver, Cytosine, Frequency-tunable coherent terahertz wave, Terahertz imaging, Terahertz spectroscopy",

author = "Nishizawa, {Jun Ichi} and Tetsuo Sasaki and Ken Suto and Tetsuya Yamada and Tadao Tanabe and Takenori Tanno and Takashi Sawai and Yasuhiro Miura",

note = "Funding Information: We thank Prof. M. Watanabe, Iwate Prefectural University, for making valuable suggestions. This study was conducted as part of the Terahertz Optics Project for Medical Applications led by J. Nishizawa, organized by the Ministry of Education, Culture, Sports, Science, and Technology, of Japan. The authors thank H. Watanabe and T. Kimura for constructing the system.",

year = "2005",

month = jan,

day = "3",

doi = "10.1016/j.optcom.2004.09.064",

language = "English",

volume = "244",

pages = "469--474",

journal = "Optics Communications",

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T1 - THz imaging of nucleobases and cancerous tissue using a GaP THz-wave generator

AU - Nishizawa, Jun Ichi

AU - Sasaki, Tetsuo

AU - Suto, Ken

AU - Yamada, Tetsuya

AU - Tanabe, Tadao

AU - Tanno, Takenori

AU - Sawai, Takashi

AU - Miura, Yasuhiro

N1 - Funding Information: We thank Prof. M. Watanabe, Iwate Prefectural University, for making valuable suggestions. This study was conducted as part of the Terahertz Optics Project for Medical Applications led by J. Nishizawa, organized by the Ministry of Education, Culture, Sports, Science, and Technology, of Japan. The authors thank H. Watanabe and T. Kimura for constructing the system.

PY - 2005/1/3

Y1 - 2005/1/3

N2 - We constructed a terahertz (THz) spectroscopic imaging system using a GaP THz-wave generator with automatic scanning control, and demonstrated power-transmission imaging measurements. To characterize the system, images of polyethylene pellets containing cytosine powder at various concentrations were taken. At a resonance frequency of 2.86 THz, the imaging system detected 5000 ppm cytosine. In addition, we demonstrated that THz imaging has a possibility to distinguish regions of metastatic cancer from normal tissue in liver, by comparing a THz-wave image at 0.835 THz with that at 1.465 THz.

AB - We constructed a terahertz (THz) spectroscopic imaging system using a GaP THz-wave generator with automatic scanning control, and demonstrated power-transmission imaging measurements. To characterize the system, images of polyethylene pellets containing cytosine powder at various concentrations were taken. At a resonance frequency of 2.86 THz, the imaging system detected 5000 ppm cytosine. In addition, we demonstrated that THz imaging has a possibility to distinguish regions of metastatic cancer from normal tissue in liver, by comparing a THz-wave image at 0.835 THz with that at 1.465 THz.

KW - Cancer liver

KW - Cytosine

KW - Frequency-tunable coherent terahertz wave

KW - Terahertz imaging

KW - Terahertz spectroscopy

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U2 - 10.1016/j.optcom.2004.09.064

DO - 10.1016/j.optcom.2004.09.064

M3 - Article

AN - SCOPUS:10844287060

SN - 0030-4018

VL - 244

SP - 469

EP - 474

JO - Optics Communications

JF - Optics Communications

IS - 1-6

ER -

THz imaging of nucleobases and cancerous tissue using a GaP THz-wave generator

Abstract

Keywords

ASJC Scopus subject areas

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