TY - JOUR
T1 - Time-frequency analysis for pulse driven ultrasonic microscopy for biological tissue characterization
AU - Hozumi, N.
AU - Yamashita, R.
AU - Lee, C. K.
AU - Nagao, M.
AU - Kobayashi, K.
AU - Saijo, Y.
AU - Tanaka, M.
AU - Tanaka, N.
AU - Ohtsuki, S.
N1 - Funding Information:
The work was performed as a part of “Consortium R&D Project for Regional Revitalization” of the Ministry of Economy, Trade and Industry of Japan. A part of the work was also supported by “The 21st Century COE Program: Intelligent Human Sensing” of the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/4
Y1 - 2004/4
N2 - The authors have proposed a new type of ultrasonic microscopy for biological tissue characterization. The system is driven by a nanosecond pulse voltage, the generated acoustic wave being reflected at the front and rear side of the sliced tissue. In this report, a time-frequency analysis was applied to determine the sound speed thorough the tissue. Frequency dependence of sound speed was obtained with a myocardium of a rat sliced into 10 μm. As the reflected waveform had a significant amount of oscillating component, the waveform was once subjected to the deconvolution process. As the result, two reflections were clearly separated in time domain. Then these two reflections were separately analyzed by time-frequency analysis. Each reflection was extracted by using a proper window function. Phase angles of these reflections at the same frequency were compared. A sound speed micrograph at an arbitrary frequency in between 50 and 150 MHz was successfully obtained. A tendency was found that the sound speed slightly increases with frequency.
AB - The authors have proposed a new type of ultrasonic microscopy for biological tissue characterization. The system is driven by a nanosecond pulse voltage, the generated acoustic wave being reflected at the front and rear side of the sliced tissue. In this report, a time-frequency analysis was applied to determine the sound speed thorough the tissue. Frequency dependence of sound speed was obtained with a myocardium of a rat sliced into 10 μm. As the reflected waveform had a significant amount of oscillating component, the waveform was once subjected to the deconvolution process. As the result, two reflections were clearly separated in time domain. Then these two reflections were separately analyzed by time-frequency analysis. Each reflection was extracted by using a proper window function. Phase angles of these reflections at the same frequency were compared. A sound speed micrograph at an arbitrary frequency in between 50 and 150 MHz was successfully obtained. A tendency was found that the sound speed slightly increases with frequency.
KW - Signal processing
KW - Sound speed
KW - Time-frequency analysis
KW - Tissue characterization
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U2 - 10.1016/j.ultras.2003.11.005
DO - 10.1016/j.ultras.2003.11.005
M3 - Conference article
C2 - 15047373
AN - SCOPUS:1642585904
VL - 42
SP - 717
EP - 722
JO - Ultrasonics
JF - Ultrasonics
SN - 0041-624X
IS - 1-9
T2 - Proceedings of Ultrasonics International 2003
Y2 - 30 June 2003 through 3 July 2003
ER -