Tocotrienol improves learning and memory deficit of aged rats

Nozomi Kaneai, Kazumi Sumitani, Koji Fukui, Taisuke Koike, Hirokatsu Takatsu, Shiro Urano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To define whether tocotrienol (T-3) improves cognitive deficit during aging, effect of T-3 on learning and memory functions of aged rats was assessed. It was found that T-3 markedly counteracts the decline in learning and memory function in aged rats. Quantitative analysis of T-3 content in the rat brain showed that the aged rats fed T-3 mixture-supplemented diet revealed the transport of α- and γ-T-3 to the brain. In contrast, normal young rats fed the same diet did not exhibit brain localization. Furthermore, the T-3 inhibited age-related decreases in the expression of certain blood brain barrier (BBB) proteins, including caludin-5, occludin and junctional adhesion molecule (JAM). It was found that the activation of the cellular proto-oncogene c-Src and extracellular signal-regulated protein kinase (ERK), in the mitogen-activated protein kinase (MAPK) cell signaling pathway for neuronal cell death, was markedly inhibited by T-3. These results may reveal that aging induces partial BBB disruption caused by oxidative stress, thereby enabling the transport of T-3 through the BBB to the central nervous system, whereupon neuronal protection may be mediated by inhibition of c-Src and/or ERK activation, resulting in an improvement in age-related cognitive deficits.

Original languageEnglish
Pages (from-to)114-121
Number of pages8
JournalJournal of Clinical Biochemistry and Nutrition
Volume58
Issue number2
DOIs
Publication statusPublished - 2016 Mar 1

Fingerprint

Tocotrienols
Rats
Data storage equipment
Brain
Nutrition
Junctional Adhesion Molecules
Aging of materials
Chemical activation
Cell signaling
Occludin
Oxidative stress
Neurology
Cell death
Mitogen-Activated Protein Kinases
Protein Kinases
Chemical analysis
Blood-Brain Barrier
Proteins

Keywords

  • Aging
  • BBB
  • c-Src
  • Cognitive deficit
  • Tocotrienol

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Tocotrienol improves learning and memory deficit of aged rats. / Kaneai, Nozomi; Sumitani, Kazumi; Fukui, Koji; Koike, Taisuke; Takatsu, Hirokatsu; Urano, Shiro.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 58, No. 2, 01.03.2016, p. 114-121.

Research output: Contribution to journalArticle

Kaneai, Nozomi ; Sumitani, Kazumi ; Fukui, Koji ; Koike, Taisuke ; Takatsu, Hirokatsu ; Urano, Shiro. / Tocotrienol improves learning and memory deficit of aged rats. In: Journal of Clinical Biochemistry and Nutrition. 2016 ; Vol. 58, No. 2. pp. 114-121.
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