Toward elucidating the full spectrum of mite allergens - State of the art

Seiji Kawamoto, Tsunehiro Aki, Mitsuo Yamashita, Airo Tategaki, Takashi Fujimura, Shinji Tsuboi, Takashi Katsutani, Osamu Suzuki, Seiko Shigeta, Yoshikatsu Murooka, Kazuhisa Ono

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Our research has focused on the molecular design of immunotherapeutic vaccines and the advancement of mite-allergy diagnosis. Here, we describe the research history of the major group 1 and group 2 allergens, immunoelectrophoretic analyses covering the complete spectrum of mite allergens, our results on allergens with distinctive characteristics (a conjunctival congestion-eliciting antigen [LM2], an immunotherapeutic antigen [HM2] with high efficacy and without definite adverse reactions, and a potent T-cell stimulatory antigen [HM1] with secretion of IFN-γ), the full spectrum and immunochemical properties of the major and other important mite allergens (including our newly described allergens: a pan-allergen [tropomyosin, group 10], a potent T-cell stimulatory allergen [M-177, apolipophorin, group 14] and its peptide fragments Mag1 and Mag3, a moderate IgE-binding allergen [gelsolin/villin, group 16], an EF-hand Ca2+-binding allergen [group 17], and a less IgE-binding allergen [heat shock protein 70]), and prospects for the development of immunotherapeutic and diagnostic agents.

Original languageEnglish
Pages (from-to)285-298
Number of pages14
JournalJournal of Bioscience and Bioengineering
Volume94
Issue number4
DOIs
Publication statusPublished - 2002 Jan 1
Externally publishedYes

Keywords

  • Allergens
  • Dermatophagoides
  • House dust mites
  • IgE-binding spectrum
  • Recombinant allergens

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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    Kawamoto, S., Aki, T., Yamashita, M., Tategaki, A., Fujimura, T., Tsuboi, S., Katsutani, T., Suzuki, O., Shigeta, S., Murooka, Y., & Ono, K. (2002). Toward elucidating the full spectrum of mite allergens - State of the art. Journal of Bioscience and Bioengineering, 94(4), 285-298. https://doi.org/10.1263/jbb.94.285