Toward elucidating the full spectrum of mite allergens - State of the art

Seiji Kawamoto, Tsunehiro Aki, Mitsuo Yamashita, Airo Tategaki, Takashi Fujimura, Shinji Tsuboi, Takashi Katsutani, Osamu Suzuki, Seiko Shigeta, Yoshikatsu Murooka, Kazuhisa Ono

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Our research has focused on the molecular design of immunotherapeutic vaccines and the advancement of mite-allergy diagnosis. Here, we describe the research history of the major group 1 and group 2 allergens, immunoelectrophoretic analyses covering the complete spectrum of mite allergens, our results on allergens with distinctive characteristics (a conjunctival congestion-eliciting antigen [LM2], an immunotherapeutic antigen [HM2] with high efficacy and without definite adverse reactions, and a potent T-cell stimulatory antigen [HM1] with secretion of IFN-γ), the full spectrum and immunochemical properties of the major and other important mite allergens (including our newly described allergens: a pan-allergen [tropomyosin, group 10], a potent T-cell stimulatory allergen [M-177, apolipophorin, group 14] and its peptide fragments Mag1 and Mag3, a moderate IgE-binding allergen [gelsolin/villin, group 16], an EF-hand Ca2+-binding allergen [group 17], and a less IgE-binding allergen [heat shock protein 70]), and prospects for the development of immunotherapeutic and diagnostic agents.

Original languageEnglish
Pages (from-to)285-298
Number of pages14
JournalJournal of Bioscience and Bioengineering
Volume94
Issue number4
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Allergens
Antigens
T-cells
Immunoglobulin E
Gelsolin
Allergies
Tropomyosin
Peptide Fragments
HSP70 Heat-Shock Proteins
Vaccines
Peptides

Keywords

  • Allergens
  • Dermatophagoides
  • House dust mites
  • IgE-binding spectrum
  • Recombinant allergens

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Cite this

Toward elucidating the full spectrum of mite allergens - State of the art. / Kawamoto, Seiji; Aki, Tsunehiro; Yamashita, Mitsuo; Tategaki, Airo; Fujimura, Takashi; Tsuboi, Shinji; Katsutani, Takashi; Suzuki, Osamu; Shigeta, Seiko; Murooka, Yoshikatsu; Ono, Kazuhisa.

In: Journal of Bioscience and Bioengineering, Vol. 94, No. 4, 2002, p. 285-298.

Research output: Contribution to journalArticle

Kawamoto, S, Aki, T, Yamashita, M, Tategaki, A, Fujimura, T, Tsuboi, S, Katsutani, T, Suzuki, O, Shigeta, S, Murooka, Y & Ono, K 2002, 'Toward elucidating the full spectrum of mite allergens - State of the art', Journal of Bioscience and Bioengineering, vol. 94, no. 4, pp. 285-298. https://doi.org/10.1263/jbb.94.285
Kawamoto, Seiji ; Aki, Tsunehiro ; Yamashita, Mitsuo ; Tategaki, Airo ; Fujimura, Takashi ; Tsuboi, Shinji ; Katsutani, Takashi ; Suzuki, Osamu ; Shigeta, Seiko ; Murooka, Yoshikatsu ; Ono, Kazuhisa. / Toward elucidating the full spectrum of mite allergens - State of the art. In: Journal of Bioscience and Bioengineering. 2002 ; Vol. 94, No. 4. pp. 285-298.
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