Trinuclear Cu(II) complex for internucleoside linkage-specific cleavage of RNA.

K. Matsumura, S. Kina, J. Sumaoka, S. Tobey, E. V. Anslyn, M. Komiyama

Research output: Contribution to journalArticle


Trinuclear Cu(II) complex of N,N,N',N',N",N"-hexa[(2-pyridyl)methyl]-1,3,5-tris(aminomethyl)benzene (L3A) exhibits remarkable substrate-specificity for hydrolysis of 2'-->5' and 3'-->5' ribonucleotides. Up(2'-->5')U is hydrolyzed much efficiently than is Up(3'-->5')U, but Ap(3'-->5')A is overwhelmingly preferable to Ap(2'-->5')A.

Original languageEnglish
Pages (from-to)85-86
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number1
Publication statusPublished - 2001


ASJC Scopus subject areas

  • Medicine(all)

Cite this