Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer

Iku Yamaga; Nobuko Kawaguchi-Sakita; Yasufumi Asao; Yoshiaki Matsumoto; Aya Yoshikawa; Toshifumi Fukui; Masahiro Takada; Masako Kataoka; Masahiro Kawashima; Elham Fakhrejahani; Shotaro Kanao; Yoshie Nakayama; Mariko Tokiwa; Masae Torii; Takayuki Yagi; Takaki Sakurai; Hironori Haga; Kaori Togashi; Tsuyoshi Shiina; Masakazu Toi

doi:10.1016/j.pacs.2018.06.002

Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer

Iku Yamaga, Nobuko Kawaguchi-Sakita, Yasufumi Asao, Yoshiaki Matsumoto, Aya Yoshikawa, Toshifumi Fukui, Masahiro Takada, Masako Kataoka, Masahiro Kawashima, Elham Fakhrejahani, Shotaro Kanao, Yoshie Nakayama, Mariko Tokiwa, Masae Torii, Takayuki Yagi, Takaki Sakurai, Hironori Haga, Kaori Togashi, Tsuyoshi Shiina, Masakazu Toi

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

This study aimed to identify the characteristics of the vascular network in the superficial subcutaneous layer of the breast and to analyze differences between breasts with cancer and contralateral unaffected breasts using vessel branching points (VBPs) detected by three-dimensional photoacoustic imaging with a hemispherical detector array. In 22 patients with unilateral breast cancer, the average VBP counts to a depth of 7 mm below the skin surface were significantly greater in breasts with cancer than in the contralateral unaffected breasts (p < 0.01). The ratio of the VBP count in the breasts with cancer to that in the contralateral breasts was significantly increased in patients with a high histologic grade (p = 0.03), those with estrogen receptor-negative disease (p < 0.01), and those with highly proliferative disease (p < 0.01). These preliminary findings indicate that a higher number of VBPs in the superficial subcutaneous layer of the breast might be a biomarker for primary breast cancer.

Original language	English
Pages (from-to)	6-13
Number of pages	8
Journal	Photoacoustics
Volume	11
DOIs	https://doi.org/10.1016/j.pacs.2018.06.002
Publication status	Published - 2018 Sept
Externally published	Yes

Keywords

Biomarker
Breast cancer
Photoacoustic imaging
Vasculature
Vessel branching points

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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Yamaga, I., Kawaguchi-Sakita, N., Asao, Y., Matsumoto, Y., Yoshikawa, A., Fukui, T., Takada, M., Kataoka, M., Kawashima, M., Fakhrejahani, E., Kanao, S., Nakayama, Y., Tokiwa, M., Torii, M., Yagi, T., Sakurai, T., Haga, H., Togashi, K., Shiina, T., & Toi, M. (2018). Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer. Photoacoustics, 11, 6-13. https://doi.org/10.1016/j.pacs.2018.06.002

Yamaga, I, Kawaguchi-Sakita, N, Asao, Y, Matsumoto, Y, Yoshikawa, A, Fukui, T, Takada, M, Kataoka, M, Kawashima, M, Fakhrejahani, E, Kanao, S, Nakayama, Y, Tokiwa, M, Torii, M, Yagi, T, Sakurai, T, Haga, H, Togashi, K, Shiina, T & Toi, M 2018, 'Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer', Photoacoustics, vol. 11, pp. 6-13. https://doi.org/10.1016/j.pacs.2018.06.002

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title = "Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer",

abstract = "This study aimed to identify the characteristics of the vascular network in the superficial subcutaneous layer of the breast and to analyze differences between breasts with cancer and contralateral unaffected breasts using vessel branching points (VBPs) detected by three-dimensional photoacoustic imaging with a hemispherical detector array. In 22 patients with unilateral breast cancer, the average VBP counts to a depth of 7 mm below the skin surface were significantly greater in breasts with cancer than in the contralateral unaffected breasts (p < 0.01). The ratio of the VBP count in the breasts with cancer to that in the contralateral breasts was significantly increased in patients with a high histologic grade (p = 0.03), those with estrogen receptor-negative disease (p < 0.01), and those with highly proliferative disease (p < 0.01). These preliminary findings indicate that a higher number of VBPs in the superficial subcutaneous layer of the breast might be a biomarker for primary breast cancer.",

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author = "Iku Yamaga and Nobuko Kawaguchi-Sakita and Yasufumi Asao and Yoshiaki Matsumoto and Aya Yoshikawa and Toshifumi Fukui and Masahiro Takada and Masako Kataoka and Masahiro Kawashima and Elham Fakhrejahani and Shotaro Kanao and Yoshie Nakayama and Mariko Tokiwa and Masae Torii and Takayuki Yagi and Takaki Sakurai and Hironori Haga and Kaori Togashi and Tsuyoshi Shiina and Masakazu Toi",

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doi = "10.1016/j.pacs.2018.06.002",

language = "English",

volume = "11",

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T2 - A potential biomarker for breast cancer

AU - Yamaga, Iku

AU - Kawaguchi-Sakita, Nobuko

AU - Asao, Yasufumi

AU - Matsumoto, Yoshiaki

AU - Yoshikawa, Aya

AU - Fukui, Toshifumi

AU - Takada, Masahiro

AU - Kataoka, Masako

AU - Kawashima, Masahiro

AU - Fakhrejahani, Elham

AU - Kanao, Shotaro

AU - Nakayama, Yoshie

AU - Tokiwa, Mariko

AU - Torii, Masae

AU - Yagi, Takayuki

AU - Sakurai, Takaki

AU - Haga, Hironori

AU - Togashi, Kaori

AU - Shiina, Tsuyoshi

AU - Toi, Masakazu

N1 - Funding Information: This work is partially supported by the Innovative Techno-Hub for Integrated Medical Bio-imaging Project of the Special Coordination Funds for Promoting Science and Technology, from the Ministry of Education, Culture, Sports, Science, and Technology, Japan . Publisher Copyright: © 2018 The Authors

PY - 2018/9

Y1 - 2018/9

N2 - This study aimed to identify the characteristics of the vascular network in the superficial subcutaneous layer of the breast and to analyze differences between breasts with cancer and contralateral unaffected breasts using vessel branching points (VBPs) detected by three-dimensional photoacoustic imaging with a hemispherical detector array. In 22 patients with unilateral breast cancer, the average VBP counts to a depth of 7 mm below the skin surface were significantly greater in breasts with cancer than in the contralateral unaffected breasts (p < 0.01). The ratio of the VBP count in the breasts with cancer to that in the contralateral breasts was significantly increased in patients with a high histologic grade (p = 0.03), those with estrogen receptor-negative disease (p < 0.01), and those with highly proliferative disease (p < 0.01). These preliminary findings indicate that a higher number of VBPs in the superficial subcutaneous layer of the breast might be a biomarker for primary breast cancer.

AB - This study aimed to identify the characteristics of the vascular network in the superficial subcutaneous layer of the breast and to analyze differences between breasts with cancer and contralateral unaffected breasts using vessel branching points (VBPs) detected by three-dimensional photoacoustic imaging with a hemispherical detector array. In 22 patients with unilateral breast cancer, the average VBP counts to a depth of 7 mm below the skin surface were significantly greater in breasts with cancer than in the contralateral unaffected breasts (p < 0.01). The ratio of the VBP count in the breasts with cancer to that in the contralateral breasts was significantly increased in patients with a high histologic grade (p = 0.03), those with estrogen receptor-negative disease (p < 0.01), and those with highly proliferative disease (p < 0.01). These preliminary findings indicate that a higher number of VBPs in the superficial subcutaneous layer of the breast might be a biomarker for primary breast cancer.

KW - Biomarker

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KW - Photoacoustic imaging

KW - Vasculature

KW - Vessel branching points

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Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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