Vascular remodeling processes in an integrated microfluidic device

Nobuyuki Futai, Takanori Sano, Masahiro Sumita, Atsushi Takano, Ryuji Yokokawa, Takashi Miura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have succeeded in maintaining self-organized microvascular networks on-chip for over a month in a portable (71×26×28 mm) microfluidic co-culture system of endothelial cells and fibroblasts. We observed the long-term changes of microvascular networks in a microchannel. Perfusion through lumens may accelerate the remodeling processes. HUVECs formed stable lumens by around 100th day of cultivation, and the lumens could be maintained for at least 132 days.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1080-1081
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period17/10/2217/10/26

Keywords

  • Braille Microfluidics
  • Long-term Perfusion Culture
  • On-Chip Incubation
  • Vascular Remodeling

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Futai, N., Sano, T., Sumita, M., Takano, A., Yokokawa, R., & Miura, T. (2020). Vascular remodeling processes in an integrated microfluidic device. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1080-1081). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.