相磯 貞和

研究成果

年別の研究成果 1978 1998 2003 2004 2005 2009 2012 2022

• 7524 被引用数
• 46 h-index
• 228 Article
• 10 Review article
• 5 Conference contribution
• 5 Comment/debate
• 4 その他
  • 2 Letter
  • 1 Chapter
  • 1 Short survey

年別の研究成果

年別の研究成果

検索結果

• 2009

  ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB

  Suzuki, H., Kanekura, K., Levine, T. P., Kohno, K., Olkkonen, V. M., Aiso, S. & Matsuoka, M., 2009 2月, In: Journal of Neurochemistry. 108, 4, p. 973-985 13 p.

  研究成果: Article › 査読

  • R-SNARE Proteins 100%
  • IgA receptor 87%
  • Endoplasmic Reticulum Stress 73%
  • Motor Neurons 64%
  • Protein 27%
  97 被引用数 (Scopus)

• Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

  Chiba, T., Yamada, M., Sasabe, J., Terashita, K., Shimoda, M., Matsuoka, M. & Aiso, S., 2009 2月, In: Molecular Psychiatry. 14, 2, p. 206-222 17 p.

  研究成果: Article › 査読

  Open Access

  • Janus Kinase 2 100%
  • STAT3 Transcription Factor 85%
  • Amyloid 67%
  • Memory 51%
  • Alzheimer Disease 49%
  160 被引用数 (Scopus)

• Angiographic study of the superior laryngeal artery

  Imanishi, N., Kondoh, T., Kishi, K. & Aiso, S., 2009 8月, In: Okajimas Folia Anatomica Japonica. 86, 2, p. 61-65 5 p.

  研究成果: Article › 査読

  • Arteries 100%
  • Larynx 56%
  • lead oxide 46%
  • Angiography 43%
  • Epiglottis 37%
  3 被引用数 (Scopus)

• A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations

  Sari, Y., Chiba, T., Yamada, M., Rebec, G. V. & Aiso, S., 2009 12月 29, In: Neuroscience. 164, 4, p. 1653-1664 12 p.

  研究成果: Article › 査読

  • Colivelin 100%
  • Inbred C57BL Mouse 43%
  • Alcohols 34%
  • Peptides 29%
  • Apoptosis 28%
  17 被引用数 (Scopus)

• Cell-based in vivo dual imaging probes using genetically expressed tags and chemical contrast agents

  Hasegawa, Y., Honda, A., Umezawa, K., Niino, Y., Oka, K., Chiba, T., Aiso, S., Tanimoto, A., Citterio, D. & Suzuki, K., 2009, In: Chemical Communications. 27, p. 4040-4042 3 p.

  研究成果: Article › 査読

  • Contrast Medium 100%
  • Imaging techniques 68%
  • Probe 54%
  • Fluorescent Probe 41%
  • Magnetic resonance 31%
  2 被引用数 (Scopus)

• Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor α/WSX-1/gp130

  Hashimoto, Y., Kurita, M., Aiso, S., Nishimoto, I. & Matsuoka, M., 2009 6月 15, In: Molecular Biology of the Cell. 20, 12, p. 2864-2873 10 p.

  研究成果: Article › 査読

  • humanin 100%
  • Ciliary Neurotrophic Factor Receptor 98%
  • Cytokine Receptors 68%
  • Cell Death 43%
  • Neuroprotection 13%
  131 被引用数 (Scopus)

• Identification of biomarkers associated with migraine with aura

  Nagata, E., Hattori, H., Kato, M., Ogasawara, S., Suzuki, S., Shibata, M., Shimizu, T., Hamada, J., Osada, T., Takaoka, R., Kuwana, M., Tsunoda, T., Aiso, S., Takizawa, S., Suzuki, N. & Takagi, S., 2009 5月, In: Neuroscience Research. 64, 1, p. 104-110 7 p.

  研究成果: Article › 査読

  • Migraine with Aura 100%
  • Migraine Disorders 76%
  • Biomarkers 49%
  • fodrin 48%
  • Gene Expression 27%
  10 被引用数 (Scopus)

• In vivo il-18 supplementation ameliorates lethal acute lung injury in burn-primed endotoxemic mice: A novel anti-inflammatory role of IL-18

  Sekine, K., Fujishima, S., Sasaki, J., Ishizaka, A., Aiso, S. & Aikawa, N., 2009 11月, In: Shock. 32, 5, p. 554-562 9 p.

  研究成果: Article › 査読

  • Interleukin-18 100%
  • Acute Lung Injury 97%
  • Burns 87%
  • Anti-Inflammatory Agents 62%
  • Interleukin-10 45%
  10 被引用数 (Scopus)
• 2008

  A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB

  Nawa, M., Kanekura, K., Hashimoto, Y., Aiso, S. & Matsuoka, M., 2008 3月 1, In: Cellular Signalling. 20, 3, p. 493-505 13 p.

  研究成果: Article › 査読

  • Amyotrophic lateral sclerosis 1 100%
  • Protein Phosphatase 2 97%
  • Superoxide Dismutase-1 94%
  • Proto-Oncogene Proteins c-akt 89%
  • Cell Adhesion 70%
  25 被引用数 (Scopus)

• Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways

  Torii, K., Nishizawa, K., Kawasaki, A., Yamashita, Y., Katada, M., Ito, M., Nishimoto, I., Terashita, K., Aiso, S. & Matsuoka, M., 2008 7月 1, In: Cellular Signalling. 20, 7, p. 1256-1266 11 p.

  研究成果: Article › 査読

  • Cyclic AMP-Dependent Protein Kinases 100%
  • Catenins 75%
  • Fibroblasts 71%
  • Skin 52%
  • Glycogen Synthase Kinase 3 48%
  50 被引用数 (Scopus)

• Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease

  Yamada, M., Chiba, T., Sasabe, J., Terashita, K., Aiso, S. & Matsuoka, M., 2008 7月, In: Neuropsychopharmacology. 33, 8, p. 2020-2032 13 p.

  研究成果: Article › 査読

  • Colivelin 100%
  • humanin 54%
  • Nose 37%
  • Alzheimer Disease 36%
  • Memory 33%
  56 被引用数 (Scopus)

• Three-dimensional venous anatomy of the dermis observed using stereography

  Imanishi, N., Kishi, K., Chang, H., Nakajima, H. & Aiso, S., 2008 5月, In: Journal of Anatomy. 212, 5, p. 669-673 5 p.

  研究成果: Article › 査読

  • plexus 100%
  • dermis 99%
  • polygon 88%
  • Dermis 86%
  • anatomy 86%
  16 被引用数 (Scopus)
• 2007

  Anatomical study of cutaneous venous flow of the sole

  Imanishi, N., Kish, K., Chang, H., Nakajima, H. & Aiso, S., 2007 12月 1, In: Plastic and Reconstructive Surgery. 120, 7, p. 1906-1910 5 p.

  研究成果: Article › 査読

  • Veins 100%
  • Saphenous Vein 80%
  • Skin 78%
  • Cadaver 46%
  • Textbooks 28%
  9 被引用数 (Scopus)

• Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test

  Nishizawa, K., Torii, K., Kawasaki, A., Katada, M., Ito, M., Terashita, K., Aiso, S. & Matsuoka, M., 2007 9月, In: Biological and Pharmaceutical Bulletin. 30, 9, p. 1758-1762 5 p.

  研究成果: Article › 査読

  • Cordyceps 100%
  • Hindlimb Suspension 85%
  • Locomotion 62%
  • 5-Hydroxy-L-Tryptophan 60%
  • Antidepressive Agents 58%
  28 被引用数 (Scopus)

• CR/periphilin is a transcriptional co-repressor involved in cell cycle progression

  Kurita, M., Suzuki, H., Kawano, Y., Aiso, S. & Matsuoka, M., 2007 12月 28, In: Biochemical and Biophysical Research Communications. 364, 4, p. 930-936 7 p.

  研究成果: Article › 査読

  • Co-Repressor Proteins 100%
  • Histone Deacetylases 91%
  • Histone 83%
  • Cell Cycle 61%
  • DNA Replication 39%
  5 被引用数 (Scopus)

• D-Serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

  Sasabe, J., Chiba, T., Yamada, M., Okamoto, K., Nishimoto, I., Matsuoka, M. & Aiso, S., 2007 9月 19, In: EMBO Journal. 26, 18, p. 4149-4159 11 p.

  研究成果: Article › 査読

  • D-Serine 100%
  • Cord 80%
  • Amyotrophic Lateral Sclerosis 70%
  • Serine 63%
  • Glutamic Acid 57%
  215 被引用数 (Scopus)

• Neuroprotection against neurodegenerative diseases: Development of a novel hybrid neuroprotective peptide Colivelin

  Chiba, T., Nishimoto, I., Aiso, S. & Matsuoka, M., 2007 2月, In: Molecular Neurobiology. 35, 1, p. 55-84 30 p.

  研究成果: Article › 査読

  • Colivelin 100%
  • Neuroprotection 48%
  • Neurodegenerative Diseases 40%
  • activity-dependent neurotrophic factor 36%
  • Peptides 29%
  22 被引用数 (Scopus)

• Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal

  Kawasaki, A., Torii, K., Yamashita, Y., Nishizawa, K., Kanekura, K., Katada, M., Ito, M., Nishimoto, I., Terashita, K., Aiso, S. & Matsuoka, M., 2007 12月 1, In: Cellular Signalling. 19, 12, p. 2498-2506 9 p.

  研究成果: Article › 査読

  • Phosphatidylinositol 3-Kinase 100%
  • Fibroblasts 73%
  • Skin 54%
  • Cysteine 37%
  • Central Nervous System 29%
  46 被引用数 (Scopus)
• 2006

  Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

  Kanekura, K., Nishimoto, I., Aiso, S. & Matsuoka, M., 2006 10月 6, In: Journal of Biological Chemistry. 281, 40, p. 30223-30233 11 p.

  研究成果: Article › 査読

  • Amyotrophic Lateral Sclerosis 8 100%
  • R-SNARE Proteins 79%
  • IgA receptor 69%
  • Unfolded Protein Response 65%
  • Amyotrophic Lateral Sclerosis 56%
  152 被引用数 (Scopus)

• Colivelin prolongs survival of an ALS model mouse

  Chiba, T., Yamada, M., Sasabe, J., Terashita, K., Aiso, S., Matsuoka, M. & Nishimoto, I., 2006 5月 12, In: Biochemical and Biophysical Research Communications. 343, 3, p. 793-798 6 p.

  研究成果: Article › 査読

  • Colivelin 100%
  • activity-dependent neurotrophic factor 90%
  • Neurotrophic Factor 52%
  • Amyotrophic Lateral Sclerosis 49%
  • Intracerebroventricular 49%
  32 被引用数 (Scopus)

• Direct determination of p-hydroxymethamphetamine glucuronide in human urine by high-performance liquid chromatography

  Nakajima, R., Morishita, M., Aiso, S. & Yajima, T., 2006 4月 1, In: Chemical and Pharmaceutical Bulletin. 54, 4, p. 493-495 3 p.

  研究成果: Article › 査読

  • pholedrine 100%
  • Glucuronides 59%
  • Ion Pair 44%
  • octadecyl silane-bonded silica 43%
  • Ions 40%
  2 被引用数 (Scopus)

• Fc receptor-positive cells in remyelinating multiple sclerosis lesions

  Nakahara, J. & Aiso, S., 2006 6月 1, In: Journal of Neuropathology and Experimental Neurology. 65, 6, p. 582-591 10 p.

  研究成果: Article › 査読

  • Fc Receptors 100%
  • Oligodendrocyte Precursor Cells 80%
  • Multiple Sclerosis 73%
  • Oligodendroglia 66%
  • Remyelination 40%
  16 被引用数 (Scopus)

• Regulation of 5′-promoter activity of the rat growth hormone and growth hormone-releasing hormone receptor genes in the MtT/S and MtT/E cells

  Nogami, H., Hiraoka, Y., Inoue, K., Aiso, S. & Hisano, S., 2006 12月 1, In: Neuroendocrinology. 84, 1, p. 31-41 11 p.

  研究成果: Article › 査読

  • somatotropin releasing hormone receptor 100%
  • Growth Hormone 57%
  • Dexamethasone 27%
  • Genes 24%
  • Alitretinoin 22%
  7 被引用数 (Scopus)

• Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β

  Hashimoto, Y., Nawa, M., Chiba, T., Aiso, S., Nishimoto, I. & Matsuoka, M., 2006 5月 1, In: Journal of Neuroscience Research. 83, 6, p. 1039-1047 9 p.

  研究成果: Article › 査読

  • Transforming Growth Factors 100%
  • Amyloid 90%
  • Cell Death 72%
  • Amyloid Precursor Protein Secretases 58%
  • Neurons 58%
  22 被引用数 (Scopus)
• 2005

  A humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice

  Tajima, H., Kawasumi, M., Chiba, T., Yamada, M., Yamashita, K., Nawa, M., Kita, Y., Kouyama, K., Aiso, S., Matsuoka, M., Niikura, T. & Nishimoto, I., 2005 3月 1, In: Journal of Neuroscience Research. 79, 5, p. 714-723 10 p.

  研究成果: Article › 査読

  • Gly(14)-Humanin 100%
  • humanin 82%
  • Amyloid 44%
  • Memory 34%
  • Amnesia 21%
  86 被引用数 (Scopus)

• A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by alsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

  Kanekura, K., Hashimoto, Y., Kita, Y., Sasabe, J., Aiso, S., Nishimoto, I. & Matsuoka, M., 2005 2月 11, In: Journal of Biological Chemistry. 280, 6, p. 4532-4543 12 p.

  研究成果: Article › 査読

  • Juvenile Amyotrophic Lateral Sclerosis 2 100%
  • Antiapoptotic 77%
  • Superoxide Dismutase-1 68%
  • Phosphatidylinositol 65%
  • Cell Death 57%
  81 被引用数 (Scopus)

• Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: Characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo

  Chiba, T., Yamada, M., Hashimoto, Y., Sato, M., Sasabe, J., Kita, Y., Terashita, K., Aiso, S., Nishimoto, I. & Matsuoka, M., 2005 11月 2, In: Journal of Neuroscience. 25, 44, p. 10252-10261 10 p.

  研究成果: Article › 査読

  • Colivelin 100%
  • activity-dependent neurotrophic factor 90%
  • humanin 82%
  • Neuroprotection 48%
  • Alzheimer Disease 36%
  73 被引用数 (Scopus)

• Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity

  Obata, Y., Niikura, T., Kanekura, K., Hashimoto, Y., Kawasumi, M., Kita, Y., Aiso, S., Matsuoka, M. & Nishimoto, I., 2005 9月 1, In: Journal of Neuroscience Research. 81, 5, p. 720-729 10 p.

  研究成果: Article › 査読

  • Amyotrophic lateral sclerosis 1 100%
  • Amyotrophic Lateral Sclerosis 53%
  • Motor Neuron Disease 31%
  • Ectopic Gene Expression 27%
  • Ubiquitination 27%
  11 被引用数 (Scopus)

• Implanted cannula-mediated repetitive administration of Aβ25-35 into the mouse cerebral ventricle effectively impairs spatial working memory

  Yamada, M., Chiba, T., Sasabe, J., Nawa, M., Tajima, H., Niikura, T., Terashita, K., Aiso, S., Kita, Y., Matsuoka, M. & Nishimoto, I., 2005 11月 7, In: Behavioural Brain Research. 164, 2, p. 139-146 8 p.

  研究成果: Article › 査読

  • Cerebral Ventricles 100%
  • Spatial Memory 84%
  • Cannula 82%
  • Short-Term Memory 71%
  • Alzheimer Disease 59%
  54 被引用数 (Scopus)

• Involvement of CD45 in central nervous system myelination

  Nakahara, J., Seiwa, C., Tan-Takeuchi, K., Gotoh, M., Kishihara, K., Ogawa, M., Asou, H. & Aiso, S., 2005 5月 6, In: Neuroscience Letters. 379, 2, p. 116-121 6 p.

  研究成果: Article › 査読

  • Oligodendrocyte Precursor Cells 100%
  • Central Nervous System 55%
  • Proto-Oncogene Proteins c-fyn 42%
  • Myelin Sheath 38%
  • Protein Tyrosine Phosphatases 30%
  23 被引用数 (Scopus)

• Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection

  Hashimoto, Y., Suzuki, H., Aiso, S., Niikura, T., Nishimoto, I. & Matsuoka, M., 2005 10月 28, In: Life Sciences. 77, 24, p. 3092-3104 13 p.

  研究成果: Article › 査読

  • Humanin 100%
  • humanin 91%
  • Neuroprotection 54%
  • Tyrosine 47%
  • Protein-Tyrosine Kinases 47%
  89 被引用数 (Scopus)

• Is the platysma flap musculocutaneous? Angiographic study of the platysma

  Imanishi, N., Nakajima, H., Kishi, K., Chang, H. & Aiso, S., 2005 4月 1, In: Plastic and Reconstructive Surgery. 115, 4, p. 1018-1024 7 p.

  研究成果: Article › 査読

  • Myocutaneous Flap 100%
  • Neck 45%
  • Skin 44%
  • lead oxide 34%
  • Subcutaneous Tissue 22%
  37 被引用数 (Scopus)

• Membrane-proximal α/β stalk interactions differentially regulate integrin activation

  Kamata, T., Handa, M., Sato, Y., Ikeda, Y. & Aiso, S., 2005 7月 1, In: Journal of Biological Chemistry. 280, 26, p. 24775-24783 9 p.

  研究成果: Article › 査読

  • Integrins 100%
  • Disulfide 87%
  • Ligands 74%
  • Divalent Cations 64%
  • Membranes 63%
  41 被引用数 (Scopus)

• Synthesis of methyl 1-O-(4-hydroxymethamphetaminyl)-α-D- glucopyranouronate

  Nakajima, R., Ono, M., Aiso, S. & Akita, H., 2005 6月, In: Chemical and Pharmaceutical Bulletin. 53, 6, p. 684-687 4 p.

  研究成果: Article › 査読

  • Methamphetamine 100%
  • 4-Hydroxymethamphetamine 77%
  • pholedrine 77%
  • 4-hydroxyphenylacetate 74%
  • 4-Hydroxyphenylacetate 69%
  14 被引用数 (Scopus)

• The role of pit-1 in the regulation of the rat growth hormone-releasing hormone receptor transcription by glucocorticoids

  Nogami, H., Hiraoka, Y., Ogasawara, K., Aiso, S. & Hisano, S., 2005 12月 1, In: Journal of Molecular Endocrinology. 35, 3, p. 477-488 12 p.

  研究成果: Article › 査読

  • somatotropin releasing hormone receptor 100%
  • Glucocorticoids 55%
  • Transcription Factor Pit-1 26%
  • Transcriptional Silencer Elements 23%
  • Response Elements 16%
  3 被引用数 (Scopus)

• Transforming growth factor β2 is a neuronal death-inducing ligand for amyloid-β precursor protein

  Hashimoto, Y., Chiba, T., Yamada, M., Nawa, M., Kanekura, K., Suzuki, H., Terashita, K., Aiso, S., Nishimoto, I. & Matsuoka, M., 2005 11月, In: Molecular and Cellular Biology. 25, 21, p. 9304-9317 14 p.

  研究成果: Article › 査読

  • Amyloid beta-Protein Precursor 100%
  • Transforming Growth Factors 90%
  • Ligands 60%
  • Alzheimer Disease 33%
  • Gi-Go GTP-Binding Protein alpha Subunits 16%
  40 被引用数 (Scopus)
• 2004

  Alsin, the Product of ALS2 Gene, Suppresses SOD1 Mutant Neurotoxicity through RhoGEF Domain by Interacting with SOD1 Mutants

  Kanekura, K., Hashimoto, Y., Niikura, T., Aiso, S., Matsuoka, M. & Nishimoto, I., 2004 4月 30, In: Journal of Biological Chemistry. 279, 18, p. 19247-19256 10 p.

  研究成果: Article › 査読

  Open Access

  • Juvenile Amyotrophic Lateral Sclerosis 2 100%
  • Rho Guanine Nucleotide Exchange Factors 83%
  • Neurotoxicity 68%
  • Guanine 52%
  • Mutation 45%
  77 被引用数 (Scopus)

• Amino- and Carboxyl-Terminal Mutants of Presenilin 1 Cause Neuronal Cell Death Through Distinct Toxic Mechanisms: Study of 27 Different Presenilin 1 Mutants

  Hashimoto, Y., Tsukamoto, E., Niikura, T., Yamagishi, Y., Ishizaka, M., Aiso, S., Takashima, A. & Nishimoto, I., 2004 2月 1, In: Journal of Neuroscience Research. 75, 3, p. 417-428 12 p.

  研究成果: Article › 査読

  • Presenilin-1 100%
  • Alzheimer Disease 55%
  • Cell Death 54%
  • Poisons 53%
  • humanin 42%
  22 被引用数 (Scopus)

• Anatomical study of subcutaneous adipofascial tissue: A concept of the protective adipofascial system (PAFS) and lubricant adipofascial system (LAFS)

  Nakajima, H., Imanishi, N., Minabe, T., Kishi, K. & Aiso, S., 2004, In: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. 38, 5, p. 261-266 6 p.

  研究成果: Article › 査読

  • Lubricants 100%
  • Subcutaneous Tissue 82%
  • Cadaver 24%
  41 被引用数 (Scopus)

• Arterial anatomical features of the upper palpebra

  Kawai, K., Imanishi, N., Nakajima, H., Aiso, S., Kakibuchi, M. & Hosokawa, K., 2004 2月, In: Plastic and Reconstructive Surgery. 113, 2, p. 479-484 6 p.

  研究成果: Article › 査読

  • lead oxide 100%
  • Arteries 86%
  • Muscles 70%
  • Reconstructive Surgical Procedures 64%
  • Gelatin 62%
  26 被引用数 (Scopus)

• Arterial anatomy of the lower lip

  Kawai, K., Imanishi, N., Nakajima, H., Aiso, S., Kakibuchi, M. & Hosokawa, K., 2004, In: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. 38, 3, p. 135-139 5 p.

  研究成果: Article › 査読

  • Lip 100%
  • Anatomy 81%
  • Arteries 74%
  • Muscles 17%
  • lead oxide 12%
  25 被引用数 (Scopus)

• CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis

  Inoue, T., Fujishima, S., Ikeda, E., Yoshie, O., Tsukamoto, N., Aiso, S., Aikawa, N., Kubo, A., Matsushima, K. & Yamaguchi, K., 2004 7月, In: European Respiratory Journal. 24, 1, p. 49-56 8 p.

  研究成果: Article › 査読

  Open Access

  • Radiation Pneumonitis 100%
  • Idiopathic Pulmonary Fibrosis 86%
  • Chemokines 67%
  • CCR4 Receptors 62%
  • Pulmonary Fibrosis 62%
  51 被引用数 (Scopus)

• Characterization of V642I-AβPP-induced cytotoxicity in primary neurons

  Niikura, T., Yamada, M., Chiba, T., Aiso, S., Matsuoka, M. & Nishimoto, I., 2004 7月 1, In: Journal of Neuroscience Research. 77, 1, p. 54-62 9 p.

  研究成果: Article › 査読

  • Amyloid beta-Protein Precursor 100%
  • Neurons 53%
  • Alzheimer Disease 18%
  • Amyloid 14%
  • S-ethyl glutathione 13%
  43 被引用数 (Scopus)

• Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant

  Abe, Y., Hashimoto, Y., Tomita, Y., Terashita, K., Aiso, S., Tajima, H., Niikura, T., Matsuoka, M. & Nishimoto, I., 2004 8月 15, In: Journal of Neuroscience Research. 77, 4, p. 583-595 13 p.

  研究成果: Article › 査読

  • S-ethyl glutathione 100%
  • Presenilin-2 88%
  • Alzheimer Disease 43%
  • acetyl-aspartyl-glutamyl-valyl-aspartal 23%
  • Oxypurinol 23%
  12 被引用数 (Scopus)

• Humanin antagonists: Mutants that interfere with dimerization inhibit neuroprotection by Humanin

  Hashimoto, Y., Terashita, K., Niikura, T., Yamagishi, Y., Ishizaka, M., Kanekura, K., Chiba, T., Yamada, M., Kita, Y., Aiso, S., Matsuoka, M. & Nishimoto, I., 2004 5月, In: European Journal of Neuroscience. 19, 9, p. 2356-2364 9 p.

  研究成果: Article › 査読

  • humanin 100%
  • Dimerization 64%
  • Neuroprotection 59%
  • activity-dependent neurotrophic factor 7%
  18 被引用数 (Scopus)

• Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-β peptides via p75NTR/PLAIDD

  Hashimoto, Y., Kaneko, Y., Tsukamoto, E., Frankowski, H., Kouyama, K., Kita, Y., Niikura, T., Aiso, S., Bredesen, D. E., Matsuoka, M. & Nishimoto, I., 2004 8月 1, In: Journal of Neurochemistry. 90, 3, p. 549-558 10 p.

  研究成果: Article › 査読

  • Death Domain 100%
  • Nerve Growth Factor Receptor 92%
  • Cell Death 75%
  • Amyloid 66%
  • Peptides 44%
  54 被引用数 (Scopus)

• Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo

  Chiba, T., Hashimoto, Y., Tajima, H., Yamada, M., Kato, R., Niikura, T., Terashita, K., Schulman, H., Aiso, S., Kita, Y., Matsuoka, M. & Nishimoto, I., 2004 11月 15, In: Journal of Neuroscience Research. 78, 4, p. 542-552 11 p.

  研究成果: Article › 査読

  • activity-dependent neurotrophic factor 100%
  • Amyotrophic lateral sclerosis 1 68%
  • Superoxide Dismutase-1 64%
  • Neuroprotective Agents 52%
  • In Vitro Techniques 22%
  40 被引用数 (Scopus)

• Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest

  Kurita, M., Suzuki, H., Masai, H., Mizumoto, K., Ogata, E., Nishimoto, I., Aiso, S. & Matsuoka, M., 2004 11月 12, In: Biochemical and Biophysical Research Communications. 324, 2, p. 554-561 8 p.

  研究成果: Article › 査読

  • DNA Replication 100%
  • S Phase 98%
  • Down-Regulation 70%
  • Protein 41%
  • Nuclear Matrix 33%
  11 被引用数 (Scopus)

• Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice

  Kawasumi, M., Chiba, T., Yamada, M., Miyamae-Kaneko, M., Matsuoka, M., Nakahara, J., Tomita, T., Iwatsubo, T., Kato, S., Aiso, S., Nishimoto, I. & Kouyama, K., 2004 5月 1, In: European Journal of Neuroscience. 19, 10, p. 2826-2838 13 p.

  研究成果: Article › 査読

  • Amyloid beta-Protein Precursor 100%
  • Alzheimer Disease 66%
  • Mutation 48%
  • Genes 34%
  • Short-Term Memory 27%
  46 被引用数 (Scopus)

• The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

  Suzuki, H., Kurita, M., Mizumoto, K., Moriyama, M., Aiso, S., Nishimoto, I. & Matsuoka, M., 2004 12月 31, In: Biochemical and Biophysical Research Communications. 326, 1, p. 242-248 7 p.

  研究成果: Article › 査読

  • Tumor Suppressor Protein p14ARF 100%
  • Down-Regulation 93%
  • Neoplasms 85%
  • Tumor Suppressor Genes 65%
  13 被引用数 (Scopus)