Yoshihisa Hirota

2021

SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides

Ikeda, Y., Hirayama, A., Kofuji, S., Hirota, Y., Kamata, R., Osaka, N., Fujii, Y., Sasaki, M., Ikeda, S., Smith, E. P., Bachoo, R., Soga, T. & Sasaki, A. T., 2021 12月 1, In: Journal of biochemistry. 170, 6, p. 699-711 13 p.

研究成果: Article › 査読

2020

Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions

Nishikawa, M., Yasuda, K., Takamatsu, M., Abe, K., Okamoto, K., Horibe, K., Mano, H., Nakagawa, K., Tsugawa, N., Hirota, Y., Horie, T., Hinoi, E., Okano, T., Ikushiro, S. & Sakaki, T., 2020 12月 1, In: Scientific Reports. 10, 1, 5677.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Study on structure–activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity

Yoshimura, H., Hirota, Y., Soda, S., Okazeri, M., Takagi, Y., Takeuchi, A., Tode, C., Kamao, M., Osakabe, N. & Suhara, Y., 2020 4月 15, In: Bioorganic and Medicinal Chemistry Letters. 30, 8, 127059.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

2019

Acylated anthocyanins derived from purple carrot (: Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole

Tsutsumi, A., Horikoshi, Y., Fushimi, T., Saito, A., Koizumi, R., Fujii, Y., Hu, Q. Q., Hirota, Y., Aizawa, K. & Osakabe, N., 2019 3月, In: Food and Function. 10, 3, p. 1726-1735 10 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 10月 11, In: Molecules. 24, 20, 3667.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Generation of 1,25-dihydroxyvitamin D ₃ in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D ₃ rescued their rachitic phenotypes

Nishikawa, M., Yasuda, K., Takamatsu, M., Abe, K., Nakagawa, K., Tsugawa, N., Hirota, Y., Tanaka, K., Yamashita, S., Ikushiro, S., Suda, T., Okano, T. & Sakaki, T., 2019 1月, In: Journal of Steroid Biochemistry and Molecular Biology. 185, p. 71-79 9 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 11月 26, In: Molecules. 24, 23, 4316.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

2018

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

HirotaI, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 10月, In: PLoS ONE. 13, 10, e0199856.

研究成果: Article › 査読

2 被引用数 (Scopus)

2017

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice

Ito, M., Kudo, N., Miyake, Y., Imai, T., Unno, T., Yamashita, Y., Hirota, Y., Ashida, H. & Osakabe, N., 2017 11月, In: Experimental Gerontology. 98, p. 120-123 4 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Nongenomic effects of 1α,25-dihydroxyvitamin D₃ on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 1月 29, In: Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimura, K., Hirota, Y., Kuwahara, S., Takeuchi, A., Tode, C., Wada, A., Osakabe, N. & Suhara, Y., 2017 3月 23, In: Journal of Medicinal Chemistry. 60, 6, p. 2591-2596 6 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 11月 1, In: Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

2015

Functional characterization of the vitamin K₂ biosynthetic enzyme UBIAD1

Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 4月 15, In: PLoS ONE. 10, 4, e0125737.

研究成果: Article › 査読

35 被引用数 (Scopus)

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 9月 10, In: Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

YY1 positively regulates human UBIAD1 expression

Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 5月 1, In: Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

2014

Vitamin K₂ biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice

Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014 8月 15, In: PLoS ONE. 9, 8, e104078.

研究成果: Article › 査読

30 被引用数 (Scopus)

2013

Menadione (vitamin K₃) is a catabolic product of oral phylloquinone (vitamin K₁) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K₂) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 11月 15, In: Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

研究成果: Article › 査読

74 被引用数 (Scopus)

The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes

Nickerson, M. L., Bosley, A. D., Weiss, J. S., Kostiha, B. N., Hirota, Y., Brandt, W., Esposito, D., Kinoshita, S., Wessjohann, L., Morham, S. G., Andresson, T., Kruth, H. S., Okano, T. & Dean, M., 2013 2月, In: Human Mutation. 34, 2, p. 317-329 13 p.

研究成果: Article › 査読

55 被引用数 (Scopus)

2010

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Nakagawa, K., Hirota, Y., Sawada, N., Yuge, N., Watanabe, M., Uchino, Y., Okuda, N., Shimomura, Y., Suhara, Y. & Okano, T., 2010 11月 4, In: Nature. 468, 7320, p. 117-121 5 p.

研究成果: Article › 査読

213 被引用数 (Scopus)

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.

Hirota, Y., 2010, In: Nature. 468

研究成果: Article › 査読

2008

Design and synthesis of biologically active analogues of vitamin K₂: Evaluation of their biological activities with cultured human cell lines

Suhara, Y., Hirota, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 3月 15, In: Bioorganic and Medicinal Chemistry. 16, 6, p. 3108-3117 10 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

廣田 佳久

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廣田佳久