Yoshihisa Hirota

2020

Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions

Nishikawa, M., Yasuda, K., Takamatsu, M., Abe, K., Okamoto, K., Horibe, K., Mano, H., Nakagawa, K., Tsugawa, N., Hirota, Y., Horie, T., Hinoi, E., Okano, T., Ikushiro, S. & Sakaki, T., 2020 12 1, ： : Scientific Reports. 10, 1, 5677.

研究成果: Article

公開

2019

Acylated anthocyanins derived from purple carrot (: Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole

Tsutsumi, A., Horikoshi, Y., Fushimi, T., Saito, A., Koizumi, R., Fujii, Y., Hu, Q. Q., Hirota, Y., Aizawa, K. & Osakabe, N., 2019 3 1, ： : Food and Function. 10, 3, p. 1726-1735 10 p.

研究成果: Article

5 引用（Scopus）

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 10 11, ： : Molecules. 24, 20, 3667.

研究成果: Article

公開

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 11 26, ： : Molecules. 24, 23, 4316.

研究成果: Article

公開

2018

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

Hirota, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 10 1, ： : PLoS One. 13, 10, e0199856.

研究成果: Article

1 引用（Scopus）

Generation of 1,25-dihydroxyvitamin D₃ in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D₃ rescued their rachitic phenotypes

Nishikawa, M., Yasuda, K., Takamatsu, M., Abe, K., Nakagawa, K., Tsugawa, N., Hirota, Y., Tanaka, K., Yamashita, S., Ikushiro, S., Suda, T., Okano, T. & Sakaki, T., 2018 1 1, (Accepted/In press) ： : Journal of Steroid Biochemistry and Molecular Biology.

研究成果: Article

5 引用（Scopus）

2017

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice

Ito, M., Kudo, N., Miyake, Y., Imai, T., Unno, T., Yamashita, Y., Hirota, Y., Ashida, H. & Osakabe, N., 2017 11 1, ： : Experimental Gerontology. 98, p. 120-123 4 p.

研究成果: Article

3 引用（Scopus）

Nongenomic effects of 1α,25-dihydroxyvitamin D₃ on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 1 29, ： : Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.

研究成果: Article

5 引用（Scopus）

Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimura, K., Hirota, Y., Kuwahara, S., Takeuchi, A., Tode, C., Wada, A., Osakabe, N. & Suhara, Y., 2017 3 23, ： : Journal of Medicinal Chemistry. 60, 6, p. 2591-2596 6 p.

研究成果: Article

9 引用（Scopus）

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 11 1, ： : Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.

研究成果: Article

4 引用（Scopus）

2015

Functional characterization of the vitamin K<inf>2</inf> biosynthetic enzyme UBIAD1

Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 4 15, ： : PLoS One. 10, 4, e0125737.

研究成果: Article

19 引用（Scopus）

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 9 10, ： : Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.

研究成果: Article

4 引用（Scopus）

YY1 positively regulates human UBIAD1 expression

Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 5 1, ： : Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.

研究成果: Article

5 引用（Scopus）

2014

Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice

Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014, ： : PLoS One. 9, 8, p. e104078

研究成果: Article

19 引用（Scopus）

2013

Menadione (vitamin K₃) is a catabolic product of oral phylloquinone (vitamin K₁) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K₂) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 11 15, ： : Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

研究成果: Article

50 引用（Scopus）

The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes

Nickerson, M. L., Bosley, A. D., Weiss, J. S., Kostiha, B. N., Hirota, Y., Brandt, W., Esposito, D., Kinoshita, S., Wessjohann, L., Morham, S. G., Andresson, T., Kruth, H. S., Okano, T. & Dean, M., 2013 2 1, ： : Human Mutation. 34, 2, p. 317-329 13 p.

研究成果: Article

42 引用（Scopus）

2010

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Nakagawa, K., Hirota, Y., Sawada, N., Yuge, N., Watanabe, M., Uchino, Y., Okuda, N., Shimomura, Y., Suhara, Y. & Okano, T., 2010 11 4, ： : Nature. 468, 7320, p. 117-121 5 p.

研究成果: Article

164 引用（Scopus）

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.

Hirota, Y., 2010, ： : Nature. 468

研究成果: Article

2008

Design and synthesis of biologically active analogues of vitamin K₂: Evaluation of their biological activities with cultured human cell lines

Suhara, Y., Hirota, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 3 15, ： : Bioorganic and Medicinal Chemistry. 16, 6, p. 3108-3117 10 p.

研究成果: Article

12 引用（Scopus）

廣田 佳久

廣田佳久