廣田佳久

准教授

生命科学科

出典: Scopus
Pureの文献数とScopusの被引用数に基づいて算出されます

年別の研究成果

Pureに変更を加えた場合、すぐここに表示されます。

421 被引用数
8 h-index
20 Article
2 Comment/debate
1 Review article

20 件

フィルター

2020
Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions
Nishikawa, M., Yasuda, K., Takamatsu, M., Abe, K., Okamoto, K., Horibe, K., Mano, H., Nakagawa, K., Tsugawa, N., Hirota, Y., Horie, T., Hinoi, E., Okano, T., Ikushiro, S. & Sakaki, T., 2020 12 1, In: Scientific Reports. 10, 1, 5677.
研究成果: Article › 査読

Open Access
1 被引用数 (Scopus)
Study on structure–activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity
Yoshimura, H., Hirota, Y., Soda, S., Okazeri, M., Takagi, Y., Takeuchi, A., Tode, C., Kamao, M., Osakabe, N. & Suhara, Y., 2020 4 15, In: Bioorganic and Medicinal Chemistry Letters. 30, 8, 127059.
研究成果: Article › 査読

Open Access
2019
Acylated anthocyanins derived from purple carrot (: Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole
Tsutsumi, A., Horikoshi, Y., Fushimi, T., Saito, A., Koizumi, R., Fujii, Y., Hu, Q. Q., Hirota, Y., Aizawa, K. & Osakabe, N., 2019 3, In: Food and Function. 10, 3, p. 1726-1735 10 p.
研究成果: Article › 査読
7 被引用数 (Scopus)
Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity
Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 10 11, In: Molecules. 24, 20, 3667.
研究成果: Article › 査読

Open Access
1 被引用数 (Scopus)
Generation of 1,25-dihydroxyvitamin D ₃ in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D ₃ rescued their rachitic phenotypes
Nishikawa, M., Yasuda, K., Takamatsu, M., Abe, K., Nakagawa, K., Tsugawa, N., Hirota, Y., Tanaka, K., Yamashita, S., Ikushiro, S., Suda, T., Okano, T. & Sakaki, T., 2019 1, In: Journal of Steroid Biochemistry and Molecular Biology. 185, p. 71-79 9 p.
研究成果: Article › 査読
8 被引用数 (Scopus)
Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives
Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 11 26, In: Molecules. 24, 23, 4316.
研究成果: Article › 査読

Open Access
1 被引用数 (Scopus)
2018
Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice
HirotaI, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 10, In: PLoS ONE. 13, 10, e0199856.
研究成果: Article › 査読
1 被引用数 (Scopus)
2017
Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice
Ito, M., Kudo, N., Miyake, Y., Imai, T., Unno, T., Yamashita, Y., Hirota, Y., Ashida, H. & Osakabe, N., 2017 11, In: Experimental Gerontology. 98, p. 120-123 4 p.
研究成果: Article › 査読
3 被引用数 (Scopus)
Nongenomic effects of 1α,25-dihydroxyvitamin D₃ on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice
Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 1 29, In: Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.
研究成果: Article › 査読
5 被引用数 (Scopus)
Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells
Kimura, K., Hirota, Y., Kuwahara, S., Takeuchi, A., Tode, C., Wada, A., Osakabe, N. & Suhara, Y., 2017 3 23, In: Journal of Medicinal Chemistry. 60, 6, p. 2591-2596 6 p.
研究成果: Article › 査読
10 被引用数 (Scopus)
Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities
Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 11 1, In: Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.
研究成果: Article › 査読
4 被引用数 (Scopus)
2015
Functional characterization of the vitamin K₂ biosynthetic enzyme UBIAD1
Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 4 15, In: PLoS ONE. 10, 4, e0125737.
研究成果: Article › 査読
25 被引用数 (Scopus)
Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells
Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 9 10, In: Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.
研究成果: Article › 査読
5 被引用数 (Scopus)
YY1 positively regulates human UBIAD1 expression
Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 5 1, In: Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.
研究成果: Article › 査読
6 被引用数 (Scopus)
2014
Vitamin K₂ biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice
Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014 8 15, In: PLoS ONE. 9, 8, e104078.
研究成果: Article › 査読
22 被引用数 (Scopus)
2013
Menadione (vitamin K₃) is a catabolic product of oral phylloquinone (vitamin K₁) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K₂) in rats
Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 11 15, In: Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.
研究成果: Article › 査読
63 被引用数 (Scopus)
The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes
Nickerson, M. L., Bosley, A. D., Weiss, J. S., Kostiha, B. N., Hirota, Y., Brandt, W., Esposito, D., Kinoshita, S., Wessjohann, L., Morham, S. G., Andresson, T., Kruth, H. S., Okano, T. & Dean, M., 2013 2, In: Human Mutation. 34, 2, p. 317-329 13 p.
研究成果: Article › 査読
48 被引用数 (Scopus)
2010
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
Nakagawa, K., Hirota, Y., Sawada, N., Yuge, N., Watanabe, M., Uchino, Y., Okuda, N., Shimomura, Y., Suhara, Y. & Okano, T., 2010 11 4, In: Nature. 468, 7320, p. 117-121 5 p.
研究成果: Article › 査読
184 被引用数 (Scopus)
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.
Hirota, Y., 2010, In: Nature. 468
研究成果: Article › 査読
2008
Design and synthesis of biologically active analogues of vitamin K₂: Evaluation of their biological activities with cultured human cell lines
Suhara, Y., Hirota, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 3 15, In: Bioorganic and Medicinal Chemistry. 16, 6, p. 3108-3117 10 p.
研究成果: Article › 査読
13 被引用数 (Scopus)

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