• 5581 引用
  • 40 h指数
1994 …2020

年単位の研究成果

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

  • 5581 引用
  • 40 h指数
  • 123 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey
2020
公開
2019
公開
1 引用 (Scopus)
7 引用 (Scopus)

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 11 26, : : Molecules. 24, 23, 4316.

研究成果: Article

公開

UBIAD1 plays an essential role in the survival of pancreatic Acinar cells

Nakagawa, K., Fujiwara, K., Nishimura, A., Murakami, C., Kawamoto, K., Ichinose, C., Kunitou, Y., Suhara, Y., Okano, T. & Hasegawa, H., 2019 4 2, : : International journal of molecular sciences. 20, 8, 1971.

研究成果: Article

公開
2 引用 (Scopus)
2018

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 7, : : PLoS ONE. 13, 7, e0201203.

研究成果: Article

5 引用 (Scopus)

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

HirotaI, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 10, : : PLoS ONE. 13, 10, e0199856.

研究成果: Article

1 引用 (Scopus)
2017

Determination of menadione by liquid chromatography-tandem mass spectrometry using pseudo multiple reaction monitoring

Kamao, M., Hirota, Y., Suhara, Y., Tsugawa, N., Nakagawa, K., Okano, T. & Hasegawa, H., 2017, : : Analytical Sciences. 33, 7, p. 863-867 5 p.

研究成果: Comment/debate

4 引用 (Scopus)

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 1 29, : : Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.

研究成果: Article

5 引用 (Scopus)

Substitution at the C-3 position of catechins has an influence on the binding affinities against serum albumin

Ikeda, M., Ueda-Wakagi, M., Hayashibara, K., Kitano, R., Kawase, M., Kaihatsu, K., Kato, N., Suhara, Y., Osakabe, N. & Ashida, H., 2017 2 1, : : Molecules. 22, 2, 314.

研究成果: Article

7 引用 (Scopus)
9 引用 (Scopus)

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 11 1, : : Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.

研究成果: Article

4 引用 (Scopus)
2016
17 引用 (Scopus)

The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Saito, A., Nakazato, R., Suhara, Y., Shibata, M., Fukui, T., Ishii, T., Asanuma, T., Mochizuki, K., Nakayama, T. & Osakabe, N., 2016 6 1, : : Journal of Nutritional Biochemistry. 32, p. 107-114 8 p.

研究成果: Article

11 引用 (Scopus)
2015

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 9 16, : : PLoS ONE. 10, 9, e0137809.

研究成果: Article

19 引用 (Scopus)

Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1

Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 4 15, : : PLoS ONE. 10, 4, e0125737.

研究成果: Article

23 引用 (Scopus)

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 9 10, : : Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.

研究成果: Article

5 引用 (Scopus)

YY1 positively regulates human UBIAD1 expression

Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 5 1, : : Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.

研究成果: Article

6 引用 (Scopus)
2014

Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice

Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014 8 15, : : PLoS ONE. 9, 8, e104078.

研究成果: Article

22 引用 (Scopus)
2013

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11

Edson, K. Z., Prasad, B., Unadkat, J. D., Suhara, Y., Okano, T., Peter Guengerich, F. & Rettie, A. E., 2013 11 19, : : Biochemistry. 52, 46, p. 8276-8285 10 p.

研究成果: Article

52 引用 (Scopus)

Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance

Li, Q., Qi, J., Wu, Y., Kiyota, H., Tanaka, K., Suhara, Y., Ohrui, H., Suzuki, Y., Vavricka, C. J. & Gao, G. F., 2013, : : Journal of Virology. 87, 18, p. 10016-10024 9 p.

研究成果: Article

17 引用 (Scopus)

Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 11 15, : : Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

研究成果: Article

57 引用 (Scopus)
2012

Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Suhara, Y., Hanada, N., Okitsu, T., Sakai, M., Watanabe, M., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2012 2 23, : : Journal of Medicinal Chemistry. 55, 4, p. 1553-1558 6 p.

研究成果: Article

9 引用 (Scopus)

Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities

SUHARA, SUHARA., Y., Y., HANADA, HANADA., N., N., OKITSU, OKITSU., T., T., SAKAI, SAKAI., M., M., WATANABE, WATANABE., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA. & T., H. . OKANO., 2012 1 17, : : Journal of Medicinal Chemistry. 55, p. 1553-1558

研究成果: Article

9 引用 (Scopus)
2011

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

Suhara, Y., Watanabe, M., Motoyoshi, S., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2011 7 14, : : Journal of Medicinal Chemistry. 54, 13, p. 4918-4922 5 p.

研究成果: Article

19 引用 (Scopus)

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

SUHARA, SUHARA., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 12 1, : : Default journal. p. 177-177

研究成果: Article

19 引用 (Scopus)

Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor Agonists: Insight into the Biological Role of the Side Chain Part of Vitamin K

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 5 27, : : Jornal of Medicinal Chemistry. 54, p. 4918-4922

研究成果: Article

19 引用 (Scopus)

Synthesis of novel vitamin K2 analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists

Suhara, Y., Watanabe, M., Nakagawa, K., Wada, A., Ito, Y., Takeda, K., Takahashi, K. & Okano, T., 2011 6 23, : : Journal of Medicinal Chemistry. 54, 12, p. 4269-4273 5 p.

研究成果: Article

7 引用 (Scopus)

Synthesis of Novel Vitamin K2 Analogues with Modification at the ω-Terminal Position and their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., NAKAGWA, NAKAGWA., K., K., WADA, WADA., A., A., ITO, ITO., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., OKANO, OKANO. & T., T., 2011 5 11, : : Jornal of Medicinal Chemistry. 54, p. 4269-4273

研究成果: Article

7 引用 (Scopus)
2010

Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives

Wada, A., Wang, F., Suhara, Y., Yamano, Y., Okitsu, T., Nakagawa, K. & Okano, T., 2010 8 15, : : Bioorganic and Medicinal Chemistry. 18, 16, p. 5795-5806 12 p.

研究成果: Article

5 引用 (Scopus)

Identification of UBIAD1 as a Novel Human Menaquinone-4 Biosynthesis Enzyme

NAKAGAWA, NAKAGAWA., K, K., K., K., HIROTA, HIROTA., Y., Y., SAWADA, SAWADA., N., N., YUGE, YUGE., WATANABE, WATANABE., M., M., UCHINO, UCHINO., OKUDA, OKUDA., SHIMOMURA, SHIMOMURA., SUHARA, SUHARA., OKANO, OKANO. & T., T., 2010 11 1, : : Nature. 468, p. 117-121

研究成果: Article

174 引用 (Scopus)

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Nakagawa, K., Hirota, Y., Sawada, N., Yuge, N., Watanabe, M., Uchino, Y., Okuda, N., Shimomura, Y., Suhara, Y. & Okano, T., 2010 11 4, : : Nature. 468, 7320, p. 117-121 5 p.

研究成果: Article

174 引用 (Scopus)
13 引用 (Scopus)

Structure-activity Relationships in the Conversion of Vitamin K Analogues into Menaquinone-4. Substrates Essential to the Synthesis of Menaquinone-4 in Cultured Human Cell Lines.

SUHARA, SUHARA., Y, Y., Y., Y., WADA, WADA., A., A., TACHIBANA, TACHIBANA., WATANABE, WATANABE., M., M., NAKAMURA, NAKAMURA., K., K., NAKAGAWA, NAKAGAWA., OKANO, OKANO. & T., T., 2010 3 1, : : Bioorganic & Medicinal Chemistry. 18, p. 3116-3124

研究成果: Article

13 引用 (Scopus)
2009

Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells

Suhara, Y., Wada, A. & Okano, T., 2009 2 15, : : Bioorganic and Medicinal Chemistry Letters. 19, 4, p. 1054-1057 4 p.

研究成果: Article

18 引用 (Scopus)

Synthesis of 2 -Propoxy-1 ,25- dihydroxyvitamin D3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A1

SAITO, SAITO., N, N., N., N., SUHARA, SUHARA., Y., Y., ABE, ABE., D., D., KUSUDO, KUSUDO., T., T., OHTA, OHTA., M., M., SAKAKI, SAKAKI., HONZAWA, HONZAWA., S., S., FUJISHIMA, FUJISHIMA., KITTAKA, KITTAKA. & A., A., 2009 3 1, : : Bioorganic & Medicinal Chemistry. 17, p. 4296-4301

研究成果: Article

19 引用 (Scopus)

Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1

Saito, N., Suhara, Y., Abe, D., Kusudo, T., Ohta, M., Yasuda, K., Sakaki, T., Honzawa, S., Fujishima, T. & Kittaka, A., 2009 7 1, : : Bioorganic and Medicinal Chemistry. 17, 13, p. 4296-4301 6 p.

研究成果: Article

19 引用 (Scopus)
2008

Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice

Okano, T., Shimomura, Y., Yamane, M., Suhara, Y., Kamao, M., Sugiura, M. & Nakagawa, K., 2008 4 25, : : Journal of Biological Chemistry. 283, 17, p. 11270-11279 10 p.

研究成果: Article

163 引用 (Scopus)

Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice: TWO POSSIBLE ROUTE FOR MENAQUINONE-4 ACCUMULATION IN CEREBRA OF MICE

OKANO, OKANO., T, T., T., T., SHIMOMURA, SHIMOMURA., Y., Y., YAMANE, YAMANE., M., M., SUHARA, SUHARA., KAMAO, KAMAO., SUGIURA, SUGIURA., NAKAGAWA, NAKAGAWA. & K., K., 2008 11 1, : : Journal of Biological Chemistry. 283, p. 11270-11279

研究成果: Article

163 引用 (Scopus)

Conversion of Vitamin K Analogues to Menaquinone-4 in Osteoblastic Cells

SUHARA, SUHARA., Y, Y., Y., Y., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 9 1, : : Proceedings of 30th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

13 引用 (Scopus)

Design and Synthesis of Biologically Active Analogues of Vitamin K2: Evaluation of their Biological Activities with Cultured Human Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., HIROTA, HIROTA., NAKAGAWA, NAKAGAWA., K., K., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 1 1, : : Bioorganic & Medicinal Chemistry. 16, p. 3108-3117

研究成果: Article

13 引用 (Scopus)

Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women

Tsugawa, N., Shiraki, M., Suhara, Y., Kamao, M., Ozaki, R., Tanaka, K. & Okano, T., 2008 1, : : Journal of Bone and Mineral Metabolism. 26, 1, p. 79-85 7 p.

研究成果: Article

60 引用 (Scopus)

Synthesis and development of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution

Suhara, Y., Abe, S., Murakami, A., Shimomura, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 9 8, : : Tetrahedron. 64, 37, p. 8789-8796 8 p.

研究成果: Article

4 引用 (Scopus)
2007
11 引用 (Scopus)
11 引用 (Scopus)

Efficient Synthesis and Biological Evaluation of -Oxygenated Analogues of Vitamin K2: Study of Modification and Structure-activity Relationship of Vitamin K2 Metabolites

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2007 2 1, : : Bioorganic & Medicinal Chemistry Letters. 17, p. 1622-1625

研究成果: Article

6 引用 (Scopus)
6 引用 (Scopus)

Quantification of fat-soluble vitamins in human breast milk by liquid chromatography-tandem mass spectrometry

Kamao, M., Tsugawa, N., Suhara, Y., Wada, A., Mori, T., Murata, K., Nishino, R., Ukita, T., Uenishi, K., Tanaka, K. & Okano, T., 2007 11 15, : : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 859, 2, p. 192-200 9 p.

研究成果: Article

81 引用 (Scopus)

Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Suhara, Y., Oka, S., Kittaka, A., Takayama, H., Waku, K. & Sugiura, T., 2007 1 15, : : Bioorganic and Medicinal Chemistry. 15, 2, p. 854-867 14 p.

研究成果: Article

9 引用 (Scopus)