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研究成果 1994 2019

  • 5340 引用
  • 40 h指数
  • 127 Article
  • 1 Comment/debate
  • 1 Review article
2019
公開
Cytotoxicity
Bovine Serum Albumin
albumins
serums
Cell culture
1 引用 (Scopus)
公開
phylloquinone
Vitamin K
Vitamins
Ligands
ligands

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 11 26, : : Molecules. 24, 23, 4316.

研究成果: Article

公開
Naphthoquinones
liver
Liver
Derivatives
evaluation

UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells

Nakagawa, K., Fujiwara, K., Nishimura, A., Murakami, C., Kawamoto, K., Ichinose, C., Kunitou, Y., Suhara, Y., Okano, T. & Hasegawa, H., 2019 4 22, : : International journal of molecular sciences. 20, 8

研究成果: Article

公開
Dimethylallyltranstransferase
knockout mice
proteins
Proteins
cells
2018
3 引用 (Scopus)

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 7 1, : : PLoS One. 13, 7, e0201203.

研究成果: Article

Proanthocyanidins
procyanidins
brown adipose tissue
catecholamines
Catecholamines

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

Hirota, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 10 1, : : PLoS One. 13, 10, e0199856.

研究成果: Article

1alpha-hydroxycholecalciferol
vitamin D
bone formation
Bone
bones
2017
4 引用 (Scopus)

Determination of menadione by liquid chromatography-tandem mass spectrometry using pseudo multiple reaction monitoring

Kamao, M., Hirota, Y., Suhara, Y., Tsugawa, N., Nakagawa, K., Okano, T. & Hasegawa, H., 2017, : : Analytical Sciences. 33, 7, p. 863-867 5 p.

研究成果: Comment/debate

Vitamin K 3
Liquid chromatography
Mass spectrometry
Monitoring
Assays
2 引用 (Scopus)

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 1 29, : : Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.

研究成果: Article

Calcitriol
Cartilage
Vitamin D
Calcitriol Receptors
Calcium
6 引用 (Scopus)

Substitution at the C-3 position of catechins has an influence on the binding affinities against serum albumin

Ikeda, M., Ueda-Wakagi, M., Hayashibara, K., Kitano, R., Kawase, M., Kaihatsu, K., Kato, N., Suhara, Y., Osakabe, N. & Ashida, H., 2017 2 1, : : Molecules. 22, 2, 314.

研究成果: Article

Catechin
albumins
Serum Albumin
serums
affinity
3 引用 (Scopus)

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 11 1, : : Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.

研究成果: Article

Vitamin K
Derivatives
Vitamin K 2
Oxidative stress
Bioactivity
2016
15 引用 (Scopus)
AMP-Activated Protein Kinases
Butoxamine
Muscle
Messenger RNA
Proteins
10 引用 (Scopus)

The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Saito, A., Nakazato, R., Suhara, Y., Shibata, M., Fukui, T., Ishii, T., Asanuma, T., Mochizuki, K., Nakayama, T. & Osakabe, N., 2016 6 1, : : Journal of Nutritional Biochemistry. 32, p. 107-114 8 p.

研究成果: Article

Microcirculation
Hemodynamics
Blood pressure
Rats
Animals
2015
18 引用 (Scopus)

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 9 16, : : PLoS One. 10, 9, e0137809.

研究成果: Article

theaflavins
energy expenditure
oral administration
Genes
genes
19 引用 (Scopus)

Functional characterization of the vitamin K<inf>2</inf> biosynthetic enzyme UBIAD1

Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 4 15, : : PLoS One. 10, 4, e0125737.

研究成果: Article

Dimethylallyltranstransferase
Vitamin K 2
menaquinones
Enzymes
enzymes
4 引用 (Scopus)

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 9 10, : : Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.

研究成果: Article

5 引用 (Scopus)

YY1 positively regulates human UBIAD1 expression

Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 5 1, : : Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.

研究成果: Article

Vitamin K 3
Vitamin K
Vitamin K 1
Messenger RNA
Dimethylallyltranstransferase
2014
19 引用 (Scopus)

Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice

Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014, : : PLoS One. 9, 8, p. e104078

研究成果: Article

Dimethylallyltranstransferase
Vitamin K 2
menaquinones
embryogenesis
coenzyme Q10
2013
51 引用 (Scopus)

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11

Edson, K. Z., Prasad, B., Unadkat, J. D., Suhara, Y., Okano, T., Peter Guengerich, F. & Rettie, A. E., 2013 11 19, : : Biochemistry. 52, 46, p. 8276-8285 10 p.

研究成果: Article

Hydroxylation
Vitamin K
Metabolism
Cytochrome P-450 Enzyme System
Vitamin K 2
13 引用 (Scopus)

Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance

Li, Q., Qi, J., Wu, Y., Kiyota, H., Tanaka, K., Suhara, Y., Ohrui, H., Suzuki, Y., Vavricka, C. J. & Gao, G. F., 2013, : : Journal of Virology. 87, 18, p. 10016-10024 9 p.

研究成果: Article

sialidase
Orthomyxoviridae
serotypes
amino acid substitution
influenza
46 引用 (Scopus)

Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 11 15, : : Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

研究成果: Article

Vitamin K 1
Vitamin K 3
Vitamin K 2
Dimethylallyltranstransferase
Rats
2012
9 引用 (Scopus)

Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Suhara, Y., Hanada, N., Okitsu, T., Sakai, M., Watanabe, M., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2012 2 23, : : Journal of Medicinal Chemistry. 55, 4, p. 1553-1558 6 p.

研究成果: Article

9 引用 (Scopus)

Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities

SUHARA, SUHARA., Y., Y., HANADA, HANADA., N., N., OKITSU, OKITSU., T., T., SAKAI, SAKAI., M., M., WATANABE, WATANABE., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA. & T., H. . OKANO., 2012 1 17, : : Journal of Medicinal Chemistry. 55, p. 1553-1558

研究成果: Article

2011
18 引用 (Scopus)

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

Suhara, Y., Watanabe, M., Motoyoshi, S., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2011 7 14, : : Journal of Medicinal Chemistry. 54, 13, p. 4918-4922 5 p.

研究成果: Article

18 引用 (Scopus)

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

SUHARA, SUHARA., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 12 1, : : Default journal. p. 177-177

研究成果: Article

18 引用 (Scopus)

Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor Agonists: Insight into the Biological Role of the Side Chain Part of Vitamin K

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 5 27, : : Jornal of Medicinal Chemistry. 54, p. 4918-4922

研究成果: Article

7 引用 (Scopus)

Synthesis of novel vitamin K2 analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists

Suhara, Y., Watanabe, M., Nakagawa, K., Wada, A., Ito, Y., Takeda, K., Takahashi, K. & Okano, T., 2011 6 23, : : Journal of Medicinal Chemistry. 54, 12, p. 4269-4273 5 p.

研究成果: Article

7 引用 (Scopus)

Synthesis of Novel Vitamin K2 Analogues with Modification at the ω-Terminal Position and their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., NAKAGWA, NAKAGWA., K., K., WADA, WADA., A., A., ITO, ITO., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., OKANO, OKANO. & T., T., 2011 5 11, : : Jornal of Medicinal Chemistry. 54, p. 4269-4273

研究成果: Article

2010
5 引用 (Scopus)

Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives

Wada, A., Wang, F., Suhara, Y., Yamano, Y., Okitsu, T., Nakagawa, K. & Okano, T., 2010 8 15, : : Bioorganic and Medicinal Chemistry. 18, 16, p. 5795-5806 12 p.

研究成果: Article

Derivatives
Retinoids
Tretinoin
Dermatology
Apoptosis
156 引用 (Scopus)

Identification of UBIAD1 as a Novel Human Menaquinone-4 Biosynthesis Enzyme

NAKAGAWA, NAKAGAWA., K, K., K., K., HIROTA, HIROTA., Y., Y., SAWADA, SAWADA., N., N., YUGE, YUGE., WATANABE, WATANABE., M., M., UCHINO, UCHINO., OKUDA, OKUDA., SHIMOMURA, SHIMOMURA., SUHARA, SUHARA., OKANO, OKANO. & T., T., 2010 11 1, : : Nature. 468, p. 117-121

研究成果: Article

156 引用 (Scopus)

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Nakagawa, K., Hirota, Y., Sawada, N., Yuge, N., Watanabe, M., Uchino, Y., Okuda, N., Shimomura, Y., Suhara, Y. & Okano, T., 2010 11 4, : : Nature. 468, 7320, p. 117-121 5 p.

研究成果: Article

12 引用 (Scopus)
Vitamin K
Cells
Substrates
Animals
Tissue
12 引用 (Scopus)

Structure-activity Relationships in the Conversion of Vitamin K Analogues into Menaquinone-4. Substrates Essential to the Synthesis of Menaquinone-4 in Cultured Human Cell Lines.

SUHARA, SUHARA., Y, Y., Y., Y., WADA, WADA., A., A., TACHIBANA, TACHIBANA., WATANABE, WATANABE., M., M., NAKAMURA, NAKAMURA., K., K., NAKAGAWA, NAKAGAWA., OKANO, OKANO. & T., T., 2010 3 1, : : Bioorganic & Medicinal Chemistry. 18, p. 3116-3124

研究成果: Article

2009
18 引用 (Scopus)

Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells

Suhara, Y., Wada, A. & Okano, T., 2009 2 15, : : Bioorganic and Medicinal Chemistry Letters. 19, 4, p. 1054-1057 4 p.

研究成果: Article

Bone
Vitamin K
Carboxylation
Vitamin K 1
Osteocalcin
18 引用 (Scopus)

Synthesis of 2 -Propoxy-1 ,25- dihydroxyvitamin D3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A1

SAITO, SAITO., N, N., N., N., SUHARA, SUHARA., Y., Y., ABE, ABE., D., D., KUSUDO, KUSUDO., T., T., OHTA, OHTA., M., M., SAKAKI, SAKAKI., HONZAWA, HONZAWA., S., S., FUJISHIMA, FUJISHIMA., KITTAKA, KITTAKA. & A., A., 2009 3 1, : : Bioorganic & Medicinal Chemistry. 17, p. 4296-4301

研究成果: Article

18 引用 (Scopus)

Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1

Saito, N., Suhara, Y., Abe, D., Kusudo, T., Ohta, M., Yasuda, K., Sakaki, T., Honzawa, S., Fujishima, T. & Kittaka, A., 2009 7 1, : : Bioorganic and Medicinal Chemistry. 17, 13, p. 4296-4301 6 p.

研究成果: Article

Calcitriol
Metabolism
Rats
Cholecalciferol
Glucose
2008
150 引用 (Scopus)

Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice

Okano, T., Shimomura, Y., Yamane, M., Suhara, Y., Kamao, M., Sugiura, M. & Nakagawa, K., 2008 4 25, : : Journal of Biological Chemistry. 283, 17, p. 11270-11279 10 p.

研究成果: Article

Vitamin K 1
Vitamin K 2
Vitamin K 3
Vitamin K
Tissue
150 引用 (Scopus)

Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice: TWO POSSIBLE ROUTE FOR MENAQUINONE-4 ACCUMULATION IN CEREBRA OF MICE

OKANO, OKANO., T, T., T., T., SHIMOMURA, SHIMOMURA., Y., Y., YAMANE, YAMANE., M., M., SUHARA, SUHARA., KAMAO, KAMAO., SUGIURA, SUGIURA., NAKAGAWA, NAKAGAWA. & K., K., 2008 11 1, : : Journal of Biological Chemistry. 283, p. 11270-11279

研究成果: Article

Conversion of Vitamin K Analogues to Menaquinone-4 in Osteoblastic Cells

SUHARA, SUHARA., Y, Y., Y., Y., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 9 1, : : Proceedings of 30th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

12 引用 (Scopus)
Vitamin K 2
Bioactivity
Cells
Carboxylation
Apoptosis
12 引用 (Scopus)

Design and Synthesis of Biologically Active Analogues of Vitamin K2: Evaluation of their Biological Activities with Cultured Human Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., HIROTA, HIROTA., NAKAGAWA, NAKAGAWA., K., K., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 1 1, : : Bioorganic & Medicinal Chemistry. 16, p. 3108-3117

研究成果: Article

58 引用 (Scopus)

Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women

Tsugawa, N., Shiraki, M., Suhara, Y., Kamao, M., Ozaki, R., Tanaka, K. & Okano, T., 2008 1, : : Journal of Bone and Mineral Metabolism. 26, 1, p. 79-85 7 p.

研究成果: Article

4 引用 (Scopus)

Synthesis and development of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution

Suhara, Y., Abe, S., Murakami, A., Shimomura, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 9 8, : : Tetrahedron. 64, 37, p. 8789-8796 8 p.

研究成果: Article

Vitamin K 1
Naphthoquinones
Vitamin K
Fluorescein-5-isothiocyanate
Metabolism
2007
10 引用 (Scopus)
Plasma (human)
Vitamin K
Nutrition
Vitamins
Fats
10 引用 (Scopus)
5 引用 (Scopus)

Efficient Synthesis and Biological Evaluation of -Oxygenated Analogues of Vitamin K2: Study of Modification and Structure-activity Relationship of Vitamin K2 Metabolites

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2007 2 1, : : Bioorganic & Medicinal Chemistry Letters. 17, p. 1622-1625

研究成果: Article

5 引用 (Scopus)
Vitamin K 2
Metabolites
Apoptosis
Vitamin K
Pharmaceutical Preparations
80 引用 (Scopus)

Quantification of fat-soluble vitamins in human breast milk by liquid chromatography-tandem mass spectrometry

Kamao, M., Tsugawa, N., Suhara, Y., Wada, A., Mori, T., Murata, K., Nishino, R., Ukita, T., Uenishi, K., Tanaka, K. & Okano, T., 2007 11 15, : : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 859, 2, p. 192-200 9 p.

研究成果: Article

Liquid chromatography
Vitamins
Mass spectrometry
Fats
Vitamin A
9 引用 (Scopus)

Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Suhara, Y., Oka, S., Kittaka, A., Takayama, H., Waku, K. & Sugiura, T., 2007 1 15, : : Bioorganic and Medicinal Chemistry. 15, 2, p. 854-867 14 p.

研究成果: Article

Cannabinoid Receptors
Cannabinoid Receptor CB2
Ligands
Cannabinoid Receptor CB1
Carbon

Synthesis and Biological Evaluation of Vitamin K2 Metabolites

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., KAMAO, KAMAO., M., M., MIMATSU, MIMATSU., S., S., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2007 9 1, : : Proceedings of 29th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article