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研究成果 1994 2019

  • 5340 引用
  • 40 h指数
  • 127 Article
  • 1 Comment/debate
  • 1 Review article
1994
10 引用 (Scopus)
9 引用 (Scopus)

Protective Effect of Sodium L-Malate, an Active Constituent Isolated from Angelicae Radix, on cis-Diamminedichloroplatinum (II)-Induced Toxic Side Effect

SUGIYAMA, SUGIYAMA., K., K., UEDA, UEDA., H., H., SUHARA, SUHARA., Y., Y., KAJIMA, KAJIMA., ICHIO, ICHIO., YOKOTA, YOKOTA. & M., M., 1994 12 1, : : Chemical & Pharmaceutical Bulletin. 42, p. 2565-2568

研究成果: Article

1996
4 引用 (Scopus)

Comparison of the biological activity of synthetic N-acylated asparagine or serine linked monosaccharide lipid A analogs

Shimizu, T., Iwamoto, Y., Yanagihara, Y., Ryoyama, K., Suhara, Y., Ikeda, K. & Achiwa, K., 1996, : : Immunobiology. 196, 4, p. 321-331 11 p.

研究成果: Article

Comparison of the Biological Activity of Synthetic N-Acylated Asparagine or Serine Linked Monosaccharide Lipid A Analogues

SHIMIZU, SHIMIZU., T., T., IWAMOTO, IWAMOTO., Y., Y., YANAGIHARA, YANAGIHARA., RYOYAMA, RYOYAMA., K., K., SUHARA, SUHARA., IKEDA, IKEDA. & ACHIWA, ACHIWA., 1996 3 1, : : Immunobiology. 196, p. 321-331

研究成果: Article

80 引用 (Scopus)

Synthesis of a New Carbohydrate Mimetics: "Carbopeptoid" Containing a C-1 Carboxylate and C-2 Amino Group

SUHARA, SUHARA., Y., Y., HILDRETH, HILDRETH., K., J. E. & ICHIKAWA, ICHIKAWA., 1996 3 1, : : Tetrahedron Letters. 37, p. 1575-1578

研究成果: Article

51 引用 (Scopus)

Synthesis of Sulfated beta-1,6-Linked Oligosaccharide Mimetics: A Novel Potent Inhibitor of HIV Replication

SUHARA, SUHARA., Y., Y., ICHIKAWA, ICHIKAWA., M., M., HILDRETH, HILDRETH. & K., J. E., 1996 4 1, : : Tetrahedron Letters. 37, p. 2459-2552

研究成果: Article

60 引用 (Scopus)

Synthesis of sulfated β-1,6-linked oligosaccharide mimetics: A novel potent inhibitor of HIV replication

Suhara, Y., Ichikawa, M., Hildreth, J. E. K. & Ichikawa, Y., 1996 4 8, : : Tetrahedron Letters. 37, 15, p. 2549-2552 4 p.

研究成果: Article

Oligosaccharides
1997
26 引用 (Scopus)

Peptide-Sugar Hybrid: Like Peptide, Like Oligosaccharide

SUHARA, SUHARA., Y., Y., IZUMI, IZUMI., M., M., ICHIKAWA, ICHIKAWA., PENNO, PENNO. & M.B., M. B., 1997 11 1, : : Tetrahedron Letters. 38, p. 7167-7170

研究成果: Article

26 引用 (Scopus)

Peptide-sugar hybrids: Like peptide, like oligosaccharide

Suhara, Y., Izumi, M., Ichikawa, M., Penno, M. B. & Ichikawa, Y., 1997 10 13, : : Tetrahedron Letters. 38, 41, p. 7167-7170 4 p.

研究成果: Article

Oligosaccharides
Aspartic Acid
Sugars
Tumors
Cells
1998
209 引用 (Scopus)

1-N-Iminosugars: Potent and selective inhibitors of β-glycosidases

Ichikawa, Y., Igarashi, Y., Ichikawa, M. & Suhara, Y., 1998 4 8, : : Journal of the American Chemical Society. 120, 13, p. 3007-3018 12 p.

研究成果: Article

Glycoside Hydrolases
Glucosidases
Amination
Carbohydrates
Sugars
209 引用 (Scopus)

1-N-Iminosugars: Potent and Selective Inhibitors of beta -Glycosidases

ICHIKAWA, ICHIKAWA., Y., Y., IGARASHI, IGARASHI., M., M. & SUHARA, SUHARA., 1998 3 1, : : Journal of American Chmeical Society. 120, p. 3007-3018

研究成果: Article

27 引用 (Scopus)
Mannosidases
Mannose
glucopyranosyl-(1-3-)-1-deoxymannojirimycin
1 引用 (Scopus)
Glycosylation
Oligomers
Carbohydrates
Selectins
Acids
14 引用 (Scopus)
Glycoside Hydrolases
1999
251 引用 (Scopus)

Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor: Structure-activity relationship of 2-arachidonoylglycerol, ether- linked analogues, and related compounds

Sugiura, T., Kodaka, T., Nakane, S., Miyashita, T., Kondo, S., Suhara, Y., Takayama, H., Waku, K., Seki, C., Baba, N. & Ishima, Y., 1999 1 29, : : Journal of Biological Chemistry. 274, 5, p. 2794-2801 8 p.

研究成果: Article

Cannabinoid Receptor CB1
Ether
Cannabinoid Receptor Agonists
Neurotransmitter Agents
2-arachidonylglycerol
251 引用 (Scopus)

Evidence that the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor

SUGIURA, SUGIURA., T., T., KODAKA, KODAKA., NAKANE, NAKANE., S.:MIYASHITA, S. MIYASHITA., KONDO, KONDO., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA., H., H., WAKU, WAKU., K., K., SEKI, SEKI., C., C., BABA, BABA., N., N. & Y., ISHIMA., 1999 1 1, : : Journal of Biological Chemistry. 274, p. 2794-2801

研究成果: Article

2000
80 引用 (Scopus)

A Concise and Efficient Route to 2 alfa-( omega-Hydroxyalkoxy)-1alpha ,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor

KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y., Y., TAKAYANAGI, TAKAYANAGI., H., H., FUJISHIMA, FUJISHIMA., T., T. & TAKAYAMA, TAKAYAMA., 2000 8 1, : : Organic Letters. 2, p. 2619-2622

研究成果: Article

80 引用 (Scopus)

A concise and efficient route to 2α-(ω-hydroxyalkoxy)-1α,25-dihydroxyvitamin D3: Remarkably high affinity to vitamin D receptor

Kittaka, A., Suhara, Y., Takayanagi, H., Fujishima, T., Kurihara, M. & Takayama, H., 2000 8 24, : : Organic Letters. 2, 17, p. 2619-2622 4 p.

研究成果: Article

calciferol
Calcitriol Receptors
hormones
Calcitriol
glucose

Efficient Synthesis and Biological Evaluation of Novel 2α-Substituted 1α,25-Dihydroxy- vitamin D3 Analogues: Remarkable Potency for Calcium-Regulating Effect

SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., TANIGAWA, TANIGAWA., H., H., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., NAKAGAWA, NAKAGAWA., OKANO, OKANO., KURIHARA, KURIHARA., M., M. & TAKAYAMA, TAKAYAMA., 2000 9 1, : : Proceeding of the 10th Vitamin D Workshop.

研究成果: Article

296 引用 (Scopus)
Cannabinoid Receptor CB2
Cannabinoid Receptors
Ligands
Cannabinoid Receptor CB1
rimonabant
296 引用 (Scopus)

Evidence that 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannnabinoid CB2 Receptor

SUGIURA, SUGIURA., T., T., KONDO, KONDO., S., S., KISHIMOTO, KISHIMOTO., MIYASHITA, MIYASHITA., NAKANE, NAKANE., KODAKA, KODAKA., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA., H., H., WAKU, WAKU. & K., K., 2000 1 1, : : Journal of Biological Chemistry. 275, p. 605-612

研究成果: Article

Facile Synthesis of 2 -(Hydroxyalkoxy)-1 ,25-dihydroxyvitamin D

KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y., Y., H., TAKAYANAGI., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M., M., TAKAYAMA, TAKAYAMA. & H., H., 2000 9 1, : : Proceeding of the 10th Vitamin D Workshop.

研究成果: Article

64 引用 (Scopus)

Syntheses and biological evaluation of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues

Suhara, Y., Nihei, K. I., Tanigawa, H., Fujishima, T., Konno, K., Nakagawa, K., Okano, T. & Takayama, H., 2000 5 15, : : Bioorganic and Medicinal Chemistry Letters. 10, 10, p. 1129-1132 4 p.

研究成果: Article

Calcitriol
Bioactivity
Hydroxyl Radical
Elongation
Calcium
34 引用 (Scopus)

Synthesis and Biological Activities of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, and Its Metabolically Stable Ether-linked Analogues

SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA., H., H., NAKANE, NAKANE., S.:MIYASHITA, S. MIYASHITA., T., T., WAKU, WAKU., K., K. & SUGIURA, SUGIURA., 2000 6 1, : : Chemical & Pharmaceutical Bulletin. 48, p. 903-907

研究成果: Article

34 引用 (Scopus)
Cannabinoid Receptors
Bioactivity
Ether
Iodides
Ligands
64 引用 (Scopus)

Synthesis and Biological Evaluation of Novel 2 alfa-Substituted 1alpa,25-Dihydroxyvitamin D3 Analogues

SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., TANIGAWA, TANIGAWA., H., H., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., NAKAGAWA, NAKAGAWA., OKANO, OKANO. & TAKAYAMA, TAKAYAMA., 2000 6 1, : : Bioorganic & Medicinal Chemistry Letters. 10, p. 1129-1132

研究成果: Article

2001
92 引用 (Scopus)

Efficient and Versatile Synthesis of Novel 2alpha -Substituted 1alpha ,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors

SUHARA, SUHARA., Y, Y., NIHEI, NIHEI., K., K., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A., YAMAGUCHI, YAMAGUCHI., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., MIYATA, MIYATA., N., N., TAKAYAMA, TAKAYAMA. & H., H., 2001 11 1, : : Journal of Organic Chemistry. 66, p. 8760-8771

研究成果: Article

92 引用 (Scopus)

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

Suhara, Y., Nihei, K. I., Kurihara, M., Kittaka, A., Yamaguchi, K., Fujishima, T., Konno, K., Miyata, N. & Takayama, H., 2001 12 28, : : Journal of Organic Chemistry. 66, 26, p. 8760-8771 12 p.

研究成果: Article

Calcitriol Receptors
Calcitriol
Ligands
Xylose
Conformations
11 引用 (Scopus)

Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Suhara, Y., Nakane, S., Arai, S., Takayama, H., Waku, K., Ishima, Y. & Sugiura, T., 2001 8 6, : : Bioorganic and Medicinal Chemistry Letters. 11, 15, p. 1985-1988 4 p.

研究成果: Article

Cannabinoid Receptors
Bioactivity
Ligands
Lead compounds
Organophosphonates
2002
14 引用 (Scopus)

Design and Efficient Syntheses of New Stable 1 alpha,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., ONO, ONO., K., K., FUJISHIMA, FUJISHIMA., T., T., YOSHIDA, YOSHIDA., TAKAYAMA, TAKAYAMA. & H., H., 2002 12 1, : : Bioorganic & Medicinal Chemistry Letters. 12, p. 3533-3536

研究成果: Article

14 引用 (Scopus)

Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D3 analogues containing amide bond

Suhara, Y., Kittaka, A., Ono, K., Kurihara, M., Fujishima, T., Yoshida, A. & Takayama, H., 2002 12, : : Bioorganic and Medicinal Chemistry Letters. 12, 24, p. 3533-3536 4 p.

研究成果: Article

Mannose
Carboxylic Acids
Ketones
Amides
Derivatives
55 引用 (Scopus)

Oligomers of glycamino acid

Suhara, Y., Yamaguchi, Y., Collins, B., Schnaar, R. L., Yanagishita, M., Hildreth, J. E. K., Shimada, I. & Ichikawa, Y., 2002, : : Bioorganic and Medicinal Chemistry. 10, 6, p. 1999-2013 15 p.

研究成果: Article

Oligomers
Acids
Derivatives
L-Selectin
Cell adhesion
5 引用 (Scopus)
Calcitriol Receptors
Calcitriol
Bioactivity
Vitamin D-Binding Protein
Hormones
26 引用 (Scopus)

Synthesis and Testing of 2 alpha-Modified 1 alpha,25-Dihydroxyvitamin D3 Analogues with a Double Side Chain: Marked Cell Differenciation Activity

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., KISHIMOTO, KISHIMOTO., S., S., CALVERLEY, CALVERLEY., M., J., FUJISHIMA, FUJISHIMA., T., T., SAITO, SAITO., N., N., SUGIURA, SUGIURA., WAKU, WAKU., K., K., TAKAYAMA, TAKAYAMA. & H., H., 2002 12 1, : : Bioorganic & Medicinal Chemistry Letters. 12, p. 3255-3258

研究成果: Article

26 引用 (Scopus)

Synthesis and testing of 2α-Modified 1α,25-Dihydroxyvitamin D3 analogues with a double side chain: Marked cell differentiation activity

Suhara, Y., Kittaka, A., Kishimoto, S., Calverley, M. J., Fujishima, T., Saito, N., Sugiura, T., Waku, K. & Takayama, H., 2002 11 18, : : Bioorganic and Medicinal Chemistry Letters. 12, 22, p. 3255-3258 4 p.

研究成果: Article

Calcitriol
Cells
Derivatives
Glucose
Testing
2003
28 引用 (Scopus)

2alpha -(3-Hydroxypropyl)- and 2 alpha-(3-Hydroxypropyl)-1alpha ,25-dihydroxyvitamin D3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets

KITTAKA, KITTAKA., A., A., KURIHARA, KURIHARA., M., M., PLEG, PLEG., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA. & H., H., 2003 3 1, : : Chemical & Pharmaceutical Bulletin. 51, p. 357-358

研究成果: Article

28 引用 (Scopus)
Calcitriol Receptors
Vitamin D
Calcitriol
Hydroxyl Radical
Hydrogen bonds
24 引用 (Scopus)

Concise Synthesis and Biological Activities of 2alpha-Alkyl- and 2 alpha-( omega-Hydroxyalkyl)-20-epi-1 alpha,25-dihydroxyvitamin D3

HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., SAITO, SAITO., N., N., KISHIMOTO, KISHIMOTO., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M.:SUGIURA, M. SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA., H., H. & A., KITTAKA., 2003 10 1, : : Bioorganic & Medicinal Chemistry. 13, p. 3503-3506

研究成果: Article

24 引用 (Scopus)

Concise synthesis and biological activities of 2α-alkyl- and 2α-(ω-hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D 3

Honzawa, S., Suhara, Y., Nihei, K. I., Saito, N., Kishimoto, S., Fujishima, T., Kurihara, M., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 10 20, : : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3503-3506 4 p.

研究成果: Article

Calcitriol
Bioactivity
Calcitriol Receptors
Substitution reactions
Hormones
25 引用 (Scopus)

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs

TAKAYAMA, TAKAYAMA., H., H., KITTAKA, KITTAKA., A., A., FUJISHIMA, FUJISHIMA., T., T., SUHARA, SUHARA. & Y., Y., 2003 5 1, : : Recent Results in Cancer Research164 (Vitamin D Analogs in Cancer Prevention and Therapy). 164, p. 289-317

研究成果: Article

Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2alpha - and 2beta -Alkylated 1alpha ,25-Dihydroxy-19-norvitamin D3 Analogues

YOSHIDA, YOSHIDA., A., A., ONO, ONO., K., K., SUHARA, SUHARA., Y., Y., SAITO, SAITO., N., N., TAKAYAMA, TAKAYAMA., H., H. & KITTAKA, KITTAKA., 2003 6 1, : : Synlett. 8, p. 1175-1179

研究成果: Article

28 引用 (Scopus)

Efficient and convergent coupling route for the short-step synthesis of enantiopure 2α- and 2β-alkylated 1α,25-dihydroxy-19-norvitamin D3 analogues

Yoshida, A., Ono, K., Suhara, Y., Saito, N., Takayama, H. & Kittaka, A., 2003, : : Synlett. 8, p. 1175-1179 5 p.

研究成果: Article

Quinic Acid
1,25-dihydroxy-19-norvitamin D3
96 引用 (Scopus)

Efficient Synthesis of 2-Modified 1 alpha,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells

ONO, ONO., K., K., YOSHIDA, YOSHIDA., A., A., SAITO, SAITO., N., N., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., KISHIMOTO, KISHIMOTO., SUGIURA, SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA. & A., H. KITTAKA., 2003 8 1, : : Journal of Organic Chemistry. 68, p. 7407-7415

研究成果: Article

96 引用 (Scopus)

Efficient synthesis of 2-modified 1α,25-dihydroxy-19-norvitamin D3 with Julia olefination: High potency in induction of differentiation on HL-60 cells

Ono, K., Yoshida, A., Saito, N., Fujishima, T., Honzawa, S., Suhara, Y., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 9 19, : : Journal of Organic Chemistry. 68, 19, p. 7407-7415 9 p.

研究成果: Article

Calcitriol Receptors
Quinic Acid
Allylation
Ligands
Thymus