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研究成果 1994 2019

  • 5367 引用
  • 40 h指数
  • 127 Article
  • 1 Comment/debate
  • 1 Review article
Article
210 引用 (Scopus)

1-N-Iminosugars: Potent and selective inhibitors of β-glycosidases

Ichikawa, Y., Igarashi, Y., Ichikawa, M. & Suhara, Y., 1998 4 8, : : Journal of the American Chemical Society. 120, 13, p. 3007-3018 12 p.

研究成果: Article

Glycoside Hydrolases
Glucosidases
Amination
Carbohydrates
Sugars
210 引用 (Scopus)

1-N-Iminosugars: Potent and Selective Inhibitors of beta -Glycosidases

ICHIKAWA, ICHIKAWA., Y., Y., IGARASHI, IGARASHI., M., M. & SUHARA, SUHARA., 1998 3 1, : : Journal of American Chmeical Society. 120, p. 3007-3018

研究成果: Article

28 引用 (Scopus)

2alpha -(3-Hydroxypropyl)- and 2 alpha-(3-Hydroxypropyl)-1alpha ,25-dihydroxyvitamin D3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets

KITTAKA, KITTAKA., A., A., KURIHARA, KURIHARA., M., M., PLEG, PLEG., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA. & H., H., 2003 3 1, : : Chemical & Pharmaceutical Bulletin. 51, p. 357-358

研究成果: Article

28 引用 (Scopus)
Calcitriol Receptors
Vitamin D
Calcitriol
Hydroxyl Radical
Hydrogen bonds
80 引用 (Scopus)

A Concise and Efficient Route to 2 alfa-( omega-Hydroxyalkoxy)-1alpha ,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor

KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y., Y., TAKAYANAGI, TAKAYANAGI., H., H., FUJISHIMA, FUJISHIMA., T., T. & TAKAYAMA, TAKAYAMA., 2000 8 1, : : Organic Letters. 2, p. 2619-2622

研究成果: Article

80 引用 (Scopus)

A concise and efficient route to 2α-(ω-hydroxyalkoxy)-1α,25-dihydroxyvitamin D3: Remarkably high affinity to vitamin D receptor

Kittaka, A., Suhara, Y., Takayanagi, H., Fujishima, T., Kurihara, M. & Takayama, H., 2000 8 24, : : Organic Letters. 2, 17, p. 2619-2622 4 p.

研究成果: Article

calciferol
Calcitriol Receptors
hormones
Calcitriol
glucose
18 引用 (Scopus)

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 9 16, : : PLoS One. 10, 9, e0137809.

研究成果: Article

theaflavins
energy expenditure
oral administration
Genes
genes
15 引用 (Scopus)
AMP-Activated Protein Kinases
Butoxamine
Muscle
Messenger RNA
Proteins
21 引用 (Scopus)

Biological Activities of 2 -Substituted Analogues of 1 ,25-Dihydroxyvitamin D3 in Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation

TAKAHASHI, TAKAHASHI., E, E., E., E., NAKAGAWA, NAKAGAWA., K., K., SUHARA, SUHARA., Y., Y., KITTAKA, KITTAKA., A., A., NIHEI, NIHEI., KONNO, KONNO., TAKAYAMA, TAKAYAMA., H., H., OKANO, OKANO. & T., T., 2006 11 1, : : Biological & Pharmaceutical Bulletin. 29, p. 2246-2250

研究成果: Article

21 引用 (Scopus)

Biological activities of 2α-substituted analogues of 1α,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation

Takahashi, E., Nakagawa, K., Suhara, Y., Kittaka, A., Nihei, K. I., Konno, K., Takayama, H., Ozono, K. & Okano, T., 2006 11, : : Biological and Pharmaceutical Bulletin. 29, 11, p. 2246-2250 5 p.

研究成果: Article

17 引用 (Scopus)

Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines

Suhara, Y., Murakami, A., Nakagawa, K., Mizuguchi, Y. & Okano, T., 2006 10 1, : : Bioorganic and Medicinal Chemistry. 14, 19, p. 6601-6607 7 p.

研究成果: Article

Vitamin K 1
Vitamin K
Metabolism
Cells
Epoxy Compounds
17 引用 (Scopus)

Comparative Uptake, Metabolism and Utilization of Menaquinone-4 and Phylloquinone in Human Cultured Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., NAKAGAWA, NAKAGAWA., K., K., MIZUGUCHI, MIZUGUCHI., OKANO, OKANO. & T., T., 2006 8 1, : : Bioorganic & Medicinal Chemistry. 14, p. 6601-6607

研究成果: Article

4 引用 (Scopus)

Comparison of the biological activity of synthetic N-acylated asparagine or serine linked monosaccharide lipid A analogs

Shimizu, T., Iwamoto, Y., Yanagihara, Y., Ryoyama, K., Suhara, Y., Ikeda, K. & Achiwa, K., 1996, : : Immunobiology. 196, 4, p. 321-331 11 p.

研究成果: Article

Comparison of the Biological Activity of Synthetic N-Acylated Asparagine or Serine Linked Monosaccharide Lipid A Analogues

SHIMIZU, SHIMIZU., T., T., IWAMOTO, IWAMOTO., Y., Y., YANAGIHARA, YANAGIHARA., RYOYAMA, RYOYAMA., K., K., SUHARA, SUHARA., IKEDA, IKEDA. & ACHIWA, ACHIWA., 1996 3 1, : : Immunobiology. 196, p. 321-331

研究成果: Article

3 引用 (Scopus)

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 7 1, : : PLoS One. 13, 7, e0201203.

研究成果: Article

Proanthocyanidins
procyanidins
brown adipose tissue
catecholamines
Catecholamines
24 引用 (Scopus)

Concise Synthesis and Biological Activities of 2alpha-Alkyl- and 2 alpha-( omega-Hydroxyalkyl)-20-epi-1 alpha,25-dihydroxyvitamin D3

HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., SAITO, SAITO., N., N., KISHIMOTO, KISHIMOTO., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M.:SUGIURA, M. SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA., H., H. & A., KITTAKA., 2003 10 1, : : Bioorganic & Medicinal Chemistry. 13, p. 3503-3506

研究成果: Article

24 引用 (Scopus)

Concise synthesis and biological activities of 2α-alkyl- and 2α-(ω-hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D 3

Honzawa, S., Suhara, Y., Nihei, K. I., Saito, N., Kishimoto, S., Fujishima, T., Kurihara, M., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 10 20, : : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3503-3506 4 p.

研究成果: Article

Calcitriol
Bioactivity
Calcitriol Receptors
Substitution reactions
Hormones
152 引用 (Scopus)

Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice

Okano, T., Shimomura, Y., Yamane, M., Suhara, Y., Kamao, M., Sugiura, M. & Nakagawa, K., 2008 4 25, : : Journal of Biological Chemistry. 283, 17, p. 11270-11279 10 p.

研究成果: Article

Vitamin K 1
Vitamin K 2
Vitamin K 3
Vitamin K
Tissue
152 引用 (Scopus)

Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice: TWO POSSIBLE ROUTE FOR MENAQUINONE-4 ACCUMULATION IN CEREBRA OF MICE

OKANO, OKANO., T, T., T., T., SHIMOMURA, SHIMOMURA., Y., Y., YAMANE, YAMANE., M., M., SUHARA, SUHARA., KAMAO, KAMAO., SUGIURA, SUGIURA., NAKAGAWA, NAKAGAWA. & K., K., 2008 11 1, : : Journal of Biological Chemistry. 283, p. 11270-11279

研究成果: Article

Conversion of Vitamin K Analogues to Menaquinone-4 in Osteoblastic Cells

SUHARA, SUHARA., Y, Y., Y., Y., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 9 1, : : Proceedings of 30th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

51 引用 (Scopus)

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11

Edson, K. Z., Prasad, B., Unadkat, J. D., Suhara, Y., Okano, T., Peter Guengerich, F. & Rettie, A. E., 2013 11 19, : : Biochemistry. 52, 46, p. 8276-8285 10 p.

研究成果: Article

Hydroxylation
Vitamin K
Metabolism
Cytochrome P-450 Enzyme System
Vitamin K 2
25 引用 (Scopus)

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs

TAKAYAMA, TAKAYAMA., H., H., KITTAKA, KITTAKA., A., A., FUJISHIMA, FUJISHIMA., T., T., SUHARA, SUHARA. & Y., Y., 2003 5 1, : : Recent Results in Cancer Research164 (Vitamin D Analogs in Cancer Prevention and Therapy). 164, p. 289-317

研究成果: Article

14 引用 (Scopus)

Design and Efficient Syntheses of New Stable 1 alpha,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., ONO, ONO., K., K., FUJISHIMA, FUJISHIMA., T., T., YOSHIDA, YOSHIDA., TAKAYAMA, TAKAYAMA. & H., H., 2002 12 1, : : Bioorganic & Medicinal Chemistry Letters. 12, p. 3533-3536

研究成果: Article

67 引用 (Scopus)

Design and Efficient Synthesis of 2alpha-(omega-Hydroxyalkoxy)-1alpha,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity

SAITO, SAITO., N., N., SUHARA, SUHARA., Y., Y., KURIHARA, KURIHARA., M., M., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., TAKAYANAGI, TAKAYANAGI., H., H., KOZONO, KOZONO., MATSUMOTO, MATSUMOTO., OHMORI, OHMORI., MIYATA, MIYATA. & A., N. TAKAYAMA. H. KITTAKA., 2004 9 1, : : Journal of Organic Chemistry. 69, p. 7463-7471

研究成果: Article

67 引用 (Scopus)

Design and efficient synthesis of 2α-(ω-hydroxyalkoxy)- 1α,25-dihydroxyvitamin D3 analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity

Saito, N., Suhara, Y., Kurihara, M., Fujishima, T., Honzawa, S., Takayanagi, H., Kozono, T., Matsumoto, M., Ohmori, M., Miyata, N., Takayama, H. & Kittaka, A., 2004 10 29, : : Journal of Organic Chemistry. 69, 22, p. 7463-7471 9 p.

研究成果: Article

Calcitriol Receptors
Calcitriol
Thymus
Hormones
Ligands
14 引用 (Scopus)

Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D3 analogues containing amide bond

Suhara, Y., Kittaka, A., Ono, K., Kurihara, M., Fujishima, T., Yoshida, A. & Takayama, H., 2002 12, : : Bioorganic and Medicinal Chemistry Letters. 12, 24, p. 3533-3536 4 p.

研究成果: Article

Mannose
Carboxylic Acids
Ketones
Amides
Derivatives
12 引用 (Scopus)
Vitamin K 2
Bioactivity
Cells
Carboxylation
Apoptosis
12 引用 (Scopus)

Design and Synthesis of Biologically Active Analogues of Vitamin K2: Evaluation of their Biological Activities with Cultured Human Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., HIROTA, HIROTA., NAKAGAWA, NAKAGAWA., K., K., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 1 1, : : Bioorganic & Medicinal Chemistry. 16, p. 3108-3117

研究成果: Article

27 引用 (Scopus)
Mannosidases
Mannose
glucopyranosyl-(1-3-)-1-deoxymannojirimycin
98 引用 (Scopus)
Plasma (human)
High performance liquid chromatography
Mass spectrometry
Vitamin D
hydroxide ion
98 引用 (Scopus)

Determination of 25-Hydroxyvitamin D in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

TSUGAWA, TSUGAWA., N., N., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., M., M., OKANO, OKANO. & T., T., 2005 5 1, : : Analytical Chemistry. 77, p. 3001-3007

研究成果: Article

10 引用 (Scopus)
Plasma (human)
Vitamin K
Nutrition
Vitamins
Fats
10 引用 (Scopus)
52 引用 (Scopus)
Vitamin K
High performance liquid chromatography
Vitamin K 1
Fluorescence
Chromatography

Development of a Biologically Active Fluorescent-labeled Vitamin K and Monitoring of the Subcellular Distribution in Cells

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., SHIMOMURA, SHIMOMURA., NAKAGAWA, NAKAGAWA., K., K., OKANO, OKANO. & T., T., 2006 9 1, : : Proceedings of 28th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

1 引用 (Scopus)
Glycosylation
Oligomers
Carbohydrates
Selectins
Acids

Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2alpha - and 2beta -Alkylated 1alpha ,25-Dihydroxy-19-norvitamin D3 Analogues

YOSHIDA, YOSHIDA., A., A., ONO, ONO., K., K., SUHARA, SUHARA., Y., Y., SAITO, SAITO., N., N., TAKAYAMA, TAKAYAMA., H., H. & KITTAKA, KITTAKA., 2003 6 1, : : Synlett. 8, p. 1175-1179

研究成果: Article

28 引用 (Scopus)

Efficient and convergent coupling route for the short-step synthesis of enantiopure 2α- and 2β-alkylated 1α,25-dihydroxy-19-norvitamin D3 analogues

Yoshida, A., Ono, K., Suhara, Y., Saito, N., Takayama, H. & Kittaka, A., 2003, : : Synlett. 8, p. 1175-1179 5 p.

研究成果: Article

Quinic Acid
1,25-dihydroxy-19-norvitamin D3
92 引用 (Scopus)

Efficient and Versatile Synthesis of Novel 2alpha -Substituted 1alpha ,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors

SUHARA, SUHARA., Y, Y., NIHEI, NIHEI., K., K., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A., YAMAGUCHI, YAMAGUCHI., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., MIYATA, MIYATA., N., N., TAKAYAMA, TAKAYAMA. & H., H., 2001 11 1, : : Journal of Organic Chemistry. 66, p. 8760-8771

研究成果: Article

92 引用 (Scopus)

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

Suhara, Y., Nihei, K. I., Kurihara, M., Kittaka, A., Yamaguchi, K., Fujishima, T., Konno, K., Miyata, N. & Takayama, H., 2001 12 28, : : Journal of Organic Chemistry. 66, 26, p. 8760-8771 12 p.

研究成果: Article

Calcitriol Receptors
Calcitriol
Ligands
Xylose
Conformations
5 引用 (Scopus)

Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives

Wada, A., Wang, F., Suhara, Y., Yamano, Y., Okitsu, T., Nakagawa, K. & Okano, T., 2010 8 15, : : Bioorganic and Medicinal Chemistry. 18, 16, p. 5795-5806 12 p.

研究成果: Article

Derivatives
Retinoids
Tretinoin
Dermatology
Apoptosis

Efficient Synthesis and Biological Evaluation of Novel 2α-Substituted 1α,25-Dihydroxy- vitamin D3 Analogues: Remarkable Potency for Calcium-Regulating Effect

SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., TANIGAWA, TANIGAWA., H., H., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., NAKAGAWA, NAKAGAWA., OKANO, OKANO., KURIHARA, KURIHARA., M., M. & TAKAYAMA, TAKAYAMA., 2000 9 1, : : Proceeding of the 10th Vitamin D Workshop.

研究成果: Article

5 引用 (Scopus)

Efficient Synthesis and Biological Evaluation of -Oxygenated Analogues of Vitamin K2: Study of Modification and Structure-activity Relationship of Vitamin K2 Metabolites

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2007 2 1, : : Bioorganic & Medicinal Chemistry Letters. 17, p. 1622-1625

研究成果: Article