Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1994 2019

  • 5367 引用
  • 40 h指数
  • 127 Article
  • 1 Comment/debate
  • 1 Review article
2007
63 引用 (Scopus)

Vitamin K content of foods and dietary vitamin K intake in Japanese young women

Kamao, M., Suhara, Y., Tsugawa, N., Uwano, M., Yamaguchi, N., Uenishi, K., Ishida, H., Sasaki, S. & Okano, T., 2007 12, : : Journal of Nutritional Science and Vitaminology. 53, 6, p. 464-470 7 p.

研究成果: Article

vitamin K
algae
Japan
Adequate Intakes
nutrient databanks
2006
21 引用 (Scopus)

Biological Activities of 2 -Substituted Analogues of 1 ,25-Dihydroxyvitamin D3 in Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation

TAKAHASHI, TAKAHASHI., E, E., E., E., NAKAGAWA, NAKAGAWA., K., K., SUHARA, SUHARA., Y., Y., KITTAKA, KITTAKA., A., A., NIHEI, NIHEI., KONNO, KONNO., TAKAYAMA, TAKAYAMA., H., H., OKANO, OKANO. & T., T., 2006 11 1, : : Biological & Pharmaceutical Bulletin. 29, p. 2246-2250

研究成果: Article

21 引用 (Scopus)

Biological activities of 2α-substituted analogues of 1α,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation

Takahashi, E., Nakagawa, K., Suhara, Y., Kittaka, A., Nihei, K. I., Konno, K., Takayama, H., Ozono, K. & Okano, T., 2006 11, : : Biological and Pharmaceutical Bulletin. 29, 11, p. 2246-2250 5 p.

研究成果: Article

17 引用 (Scopus)

Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines

Suhara, Y., Murakami, A., Nakagawa, K., Mizuguchi, Y. & Okano, T., 2006 10 1, : : Bioorganic and Medicinal Chemistry. 14, 19, p. 6601-6607 7 p.

研究成果: Article

Vitamin K 1
Vitamin K
Metabolism
Cells
Epoxy Compounds
17 引用 (Scopus)

Comparative Uptake, Metabolism and Utilization of Menaquinone-4 and Phylloquinone in Human Cultured Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., NAKAGAWA, NAKAGAWA., K., K., MIZUGUCHI, MIZUGUCHI., OKANO, OKANO. & T., T., 2006 8 1, : : Bioorganic & Medicinal Chemistry. 14, p. 6601-6607

研究成果: Article

Development of a Biologically Active Fluorescent-labeled Vitamin K and Monitoring of the Subcellular Distribution in Cells

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., SHIMOMURA, SHIMOMURA., NAKAGAWA, NAKAGAWA., K., K., OKANO, OKANO. & T., T., 2006 9 1, : : Proceedings of 28th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

13 引用 (Scopus)

Efficient synthesis of carbopeptoid oligomers: insight into mimicry of β-peptide

Suhara, Y., Kurihara, M., Kittaka, A. & Ichikawa, Y., 2006 8 21, : : Tetrahedron. 62, 34, p. 8207-8217 11 p.

研究成果: Article

Oligomers
Peptides
Molecular modeling
Glycoside Hydrolases
Glucosamine
13 引用 (Scopus)

Efficient Synthesis of Carbopeptoid Oligomers: Insight into Mimicry of -Peptide

SUHARA, SUHARA., Y., Y., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A. & ICHIKAWA, ICHIKAWA., 2006 8 1, : : Tetrahedron. 62, p. 8207-8217

研究成果: Article

91 引用 (Scopus)

Probing a Water Channel near the A-Ring of Receptor-Bound 1 ,25-Dihydroxyvitamin D3 with Selected 2 -Substituted Analogues

HOURAI, HOURAI., S, S., S., S., FUJISHIMA, FUJISHIMA., T., T., KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y. 5, Y. ., TAKAYAMA, TAKAYAMA., H., H., ROCHEL, ROCHEL., N., N., MORAS, MORAS. & D., D., 2006 7 1, : : Journal of Medicinal Chemistry. 49, p. 5199-5205

研究成果: Article

91 引用 (Scopus)

Probing a water channel near the A-ring of receptor-bound 1α,25-dihydroxyvitamin D3 with selected 2α-substituted analogues

Hourai, S., Fujishima, T., Kittaka, A., Suhara, Y., Takayama, H., Rochel, N. & Moras, D., 2006 8 24, : : Journal of Medicinal Chemistry. 49, 17, p. 5199-5205 7 p.

研究成果: Article

Aquaporins
Calcitriol
Ligands
Calcitriol Receptors
Crystal structure
81 引用 (Scopus)

Vitamin K status of healthy Japanese women: Age-related vitamin K requirement for γ-carboxylation of osteocalcin

Tsugawa, N., Shiraki, M., Suhara, Y., Kamao, M., Tanaka, K. & Okano, T., 2006 2 1, : : American Journal of Clinical Nutrition. 83, 2, p. 380-386 7 p.

研究成果: Article

vitamin K
osteocalcin
carboxylation
bone metabolism
vitamin K deficiency
81 引用 (Scopus)

Vitamin K Status of Healthy Japanese Women; Age-related Vitamin K Requirement for gamma-Carboxylation of Osteocalcin

TSUGAWA, TSUGAWA., N., N., SHIRAKI, SHIRAKI., M., M., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., TANAKA, TANAKA., K., K., OKANO, OKANO. & T., T., 2006 1 1, : : The American Society for Nutrution. 83, p. 380-386

研究成果: Article

98 引用 (Scopus)
Plasma (human)
High performance liquid chromatography
Mass spectrometry
Vitamin D
hydroxide ion
98 引用 (Scopus)

Determination of 25-Hydroxyvitamin D in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

TSUGAWA, TSUGAWA., N., N., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., M., M., OKANO, OKANO. & T., T., 2005 5 1, : : Analytical Chemistry. 77, p. 3001-3007

研究成果: Article

52 引用 (Scopus)
Vitamin K
High performance liquid chromatography
Vitamin K 1
Fluorescence
Chromatography

Metabolism of 2 -Propoxy-1 ,25-dihydroxyvitamin D3 and 2 -(3-Hydroxypropoxy)-1 ,25 -dihydroxyvitamin D3 by Human CYP27A1 and CYP24A1.

ABE, ABE., D., D., SAKAKI, SAKAKI., T., T., KUSUDO, KUSUDO., KITTAKA, KITTAKA., A., A., SAITO, SAITO., N., N., SUHARA, SUHARA., Y., Y., FUJISHIMA, FUJISHIMA., TAKAYAMA, TAKAYAMA., H. HAMAMOTO, H. HAMAMOTO., H, H., KAMAKURA, KAMAKURA., M, M. & K., OHTA. M. INOUYE., 2005 6 1, : : Drug Metabolism and Disposition. 33, p. 778-784

研究成果: Article

25 引用 (Scopus)

Metabolism of 2α-propoxy-1α,25-dihydroxyvitamin D3 and 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1

Abe, D., Sakaki, T., Kusudo, T., Kittaka, A., Saito, N., Suhara, Y., Fujishima, T., Takayama, H., Hamamoto, H., Kamakura, M., Ohta, M. & Inouye, K., 2005 6, : : Drug Metabolism and Disposition. 33, 6, p. 778-784 7 p.

研究成果: Article

Metabolism
Rats
Metabolites
Oxidation
Calcitriol Receptors
78 引用 (Scopus)

Method for the Detection of Vitamin K Homologues in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry

SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2005 2 1, : : Analytical Chemistry. 77, p. 757-763

研究成果: Article

78 引用 (Scopus)
Plasma (human)
Vitamin K
High performance liquid chromatography
Mass spectrometry
Vitamin K 1

Vitamin K Circulating Levels and Associations with Bone Metabolism in Healthy Japanese Women

TSUGAWA, TSUGAWA., N., N., SHIRAKI, SHIRAKI., M., M., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., TANAKA, TANAKA., K., K., OKANO, OKANO. & T., T., 2005 9 1, : : Proceedings of 27th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

67 引用 (Scopus)

Design and Efficient Synthesis of 2alpha-(omega-Hydroxyalkoxy)-1alpha,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity

SAITO, SAITO., N., N., SUHARA, SUHARA., Y., Y., KURIHARA, KURIHARA., M., M., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., TAKAYANAGI, TAKAYANAGI., H., H., KOZONO, KOZONO., MATSUMOTO, MATSUMOTO., OHMORI, OHMORI., MIYATA, MIYATA. & A., N. TAKAYAMA. H. KITTAKA., 2004 9 1, : : Journal of Organic Chemistry. 69, p. 7463-7471

研究成果: Article

67 引用 (Scopus)

Design and efficient synthesis of 2α-(ω-hydroxyalkoxy)- 1α,25-dihydroxyvitamin D3 analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity

Saito, N., Suhara, Y., Kurihara, M., Fujishima, T., Honzawa, S., Takayanagi, H., Kozono, T., Matsumoto, M., Ohmori, M., Miyata, N., Takayama, H. & Kittaka, A., 2004 10 29, : : Journal of Organic Chemistry. 69, 22, p. 7463-7471 9 p.

研究成果: Article

Calcitriol Receptors
Calcitriol
Thymus
Hormones
Ligands

Synthesis of Novel 1 ,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate

SUHARA, SUHARA., Y., Y., ONO, ONO., K., K., YOSHIDA, YOSHIDA., A., A., FUJISHIMA, FUJISHIMA., T., T., SAITO, SAITO., N., N., HONZAWA, HONZAWA., S., S., KISHIMOTO, KISHIMOTO., SUGIURA, SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA. & A., H. KITTAKA., 2004 1 1, : : Heterocycles. 62, p. 426-436

研究成果: Article

4 引用 (Scopus)

Synthesis of novel 1α,25-dihydroxy-19-norvitamin D3 with an amide conjugate

Suhara, Y., Ono, K., Yoshida, A., Fujishima, T., Saito, N., Honzawa, S., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2004 1 1, : : Heterocycles. 62, p. 423-436 14 p.

研究成果: Article

Amides
Calcitriol Receptors
Thymus
Calcitriol
Ligands
2003
28 引用 (Scopus)

2alpha -(3-Hydroxypropyl)- and 2 alpha-(3-Hydroxypropyl)-1alpha ,25-dihydroxyvitamin D3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets

KITTAKA, KITTAKA., A., A., KURIHARA, KURIHARA., M., M., PLEG, PLEG., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA. & H., H., 2003 3 1, : : Chemical & Pharmaceutical Bulletin. 51, p. 357-358

研究成果: Article

28 引用 (Scopus)
Calcitriol Receptors
Vitamin D
Calcitriol
Hydroxyl Radical
Hydrogen bonds
24 引用 (Scopus)

Concise Synthesis and Biological Activities of 2alpha-Alkyl- and 2 alpha-( omega-Hydroxyalkyl)-20-epi-1 alpha,25-dihydroxyvitamin D3

HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., SAITO, SAITO., N., N., KISHIMOTO, KISHIMOTO., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M.:SUGIURA, M. SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA., H., H. & A., KITTAKA., 2003 10 1, : : Bioorganic & Medicinal Chemistry. 13, p. 3503-3506

研究成果: Article

24 引用 (Scopus)

Concise synthesis and biological activities of 2α-alkyl- and 2α-(ω-hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D 3

Honzawa, S., Suhara, Y., Nihei, K. I., Saito, N., Kishimoto, S., Fujishima, T., Kurihara, M., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 10 20, : : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3503-3506 4 p.

研究成果: Article

Calcitriol
Bioactivity
Calcitriol Receptors
Substitution reactions
Hormones
25 引用 (Scopus)

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs

TAKAYAMA, TAKAYAMA., H., H., KITTAKA, KITTAKA., A., A., FUJISHIMA, FUJISHIMA., T., T., SUHARA, SUHARA. & Y., Y., 2003 5 1, : : Recent Results in Cancer Research164 (Vitamin D Analogs in Cancer Prevention and Therapy). 164, p. 289-317

研究成果: Article

Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2alpha - and 2beta -Alkylated 1alpha ,25-Dihydroxy-19-norvitamin D3 Analogues

YOSHIDA, YOSHIDA., A., A., ONO, ONO., K., K., SUHARA, SUHARA., Y., Y., SAITO, SAITO., N., N., TAKAYAMA, TAKAYAMA., H., H. & KITTAKA, KITTAKA., 2003 6 1, : : Synlett. 8, p. 1175-1179

研究成果: Article

28 引用 (Scopus)

Efficient and convergent coupling route for the short-step synthesis of enantiopure 2α- and 2β-alkylated 1α,25-dihydroxy-19-norvitamin D3 analogues

Yoshida, A., Ono, K., Suhara, Y., Saito, N., Takayama, H. & Kittaka, A., 2003, : : Synlett. 8, p. 1175-1179 5 p.

研究成果: Article

Quinic Acid
1,25-dihydroxy-19-norvitamin D3
96 引用 (Scopus)

Efficient Synthesis of 2-Modified 1 alpha,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells

ONO, ONO., K., K., YOSHIDA, YOSHIDA., A., A., SAITO, SAITO., N., N., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., KISHIMOTO, KISHIMOTO., SUGIURA, SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA. & A., H. KITTAKA., 2003 8 1, : : Journal of Organic Chemistry. 68, p. 7407-7415

研究成果: Article

96 引用 (Scopus)

Efficient synthesis of 2-modified 1α,25-dihydroxy-19-norvitamin D3 with Julia olefination: High potency in induction of differentiation on HL-60 cells

Ono, K., Yoshida, A., Saito, N., Fujishima, T., Honzawa, S., Suhara, Y., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 9 19, : : Journal of Organic Chemistry. 68, 19, p. 7407-7415 9 p.

研究成果: Article

Calcitriol Receptors
Quinic Acid
Allylation
Ligands
Thymus
84 引用 (Scopus)

Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species

Oka, S., Tsuchie, A., Tokumura, A., Muramatsu, M., Suhara, Y., Takayama, H., Waku, K. & Sugiura, T., 2003 6, : : Journal of Neurochemistry. 85, 6, p. 1374-1381 8 p.

研究成果: Article

Ether
Brain
Dihydroxyacetone Phosphate
Cannabinoid Receptors
Rats
2002
14 引用 (Scopus)

Design and Efficient Syntheses of New Stable 1 alpha,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., ONO, ONO., K., K., FUJISHIMA, FUJISHIMA., T., T., YOSHIDA, YOSHIDA., TAKAYAMA, TAKAYAMA. & H., H., 2002 12 1, : : Bioorganic & Medicinal Chemistry Letters. 12, p. 3533-3536

研究成果: Article

14 引用 (Scopus)

Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D3 analogues containing amide bond

Suhara, Y., Kittaka, A., Ono, K., Kurihara, M., Fujishima, T., Yoshida, A. & Takayama, H., 2002 12, : : Bioorganic and Medicinal Chemistry Letters. 12, 24, p. 3533-3536 4 p.

研究成果: Article

Mannose
Carboxylic Acids
Ketones
Amides
Derivatives
55 引用 (Scopus)

Oligomers of glycamino acid

Suhara, Y., Yamaguchi, Y., Collins, B., Schnaar, R. L., Yanagishita, M., Hildreth, J. E. K., Shimada, I. & Ichikawa, Y., 2002, : : Bioorganic and Medicinal Chemistry. 10, 6, p. 1999-2013 15 p.

研究成果: Article

Oligomers
Acids
Derivatives
L-Selectin
Cell adhesion
5 引用 (Scopus)
Calcitriol Receptors
Calcitriol
Bioactivity
Vitamin D-Binding Protein
Hormones
26 引用 (Scopus)

Synthesis and Testing of 2 alpha-Modified 1 alpha,25-Dihydroxyvitamin D3 Analogues with a Double Side Chain: Marked Cell Differenciation Activity

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., KISHIMOTO, KISHIMOTO., S., S., CALVERLEY, CALVERLEY., M., J., FUJISHIMA, FUJISHIMA., T., T., SAITO, SAITO., N., N., SUGIURA, SUGIURA., WAKU, WAKU., K., K., TAKAYAMA, TAKAYAMA. & H., H., 2002 12 1, : : Bioorganic & Medicinal Chemistry Letters. 12, p. 3255-3258

研究成果: Article

26 引用 (Scopus)

Synthesis and testing of 2α-Modified 1α,25-Dihydroxyvitamin D3 analogues with a double side chain: Marked cell differentiation activity

Suhara, Y., Kittaka, A., Kishimoto, S., Calverley, M. J., Fujishima, T., Saito, N., Sugiura, T., Waku, K. & Takayama, H., 2002 11 18, : : Bioorganic and Medicinal Chemistry Letters. 12, 22, p. 3255-3258 4 p.

研究成果: Article

Calcitriol
Cells
Derivatives
Glucose
Testing
2001
92 引用 (Scopus)

Efficient and Versatile Synthesis of Novel 2alpha -Substituted 1alpha ,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors

SUHARA, SUHARA., Y, Y., NIHEI, NIHEI., K., K., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A., YAMAGUCHI, YAMAGUCHI., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., MIYATA, MIYATA., N., N., TAKAYAMA, TAKAYAMA. & H., H., 2001 11 1, : : Journal of Organic Chemistry. 66, p. 8760-8771

研究成果: Article

92 引用 (Scopus)

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

Suhara, Y., Nihei, K. I., Kurihara, M., Kittaka, A., Yamaguchi, K., Fujishima, T., Konno, K., Miyata, N. & Takayama, H., 2001 12 28, : : Journal of Organic Chemistry. 66, 26, p. 8760-8771 12 p.

研究成果: Article

Calcitriol Receptors
Calcitriol
Ligands
Xylose
Conformations
11 引用 (Scopus)

Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Suhara, Y., Nakane, S., Arai, S., Takayama, H., Waku, K., Ishima, Y. & Sugiura, T., 2001 8 6, : : Bioorganic and Medicinal Chemistry Letters. 11, 15, p. 1985-1988 4 p.

研究成果: Article

Cannabinoid Receptors
Bioactivity
Ligands
Lead compounds
Organophosphonates
2000
80 引用 (Scopus)

A Concise and Efficient Route to 2 alfa-( omega-Hydroxyalkoxy)-1alpha ,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor

KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y., Y., TAKAYANAGI, TAKAYANAGI., H., H., FUJISHIMA, FUJISHIMA., T., T. & TAKAYAMA, TAKAYAMA., 2000 8 1, : : Organic Letters. 2, p. 2619-2622

研究成果: Article