• 5571 引用
  • 40 h指数
1994 …2020

年単位の研究成果

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

  • 5571 引用
  • 40 h指数
  • 123 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey
2007

Synthesis and Biological Evaluation of Vitamin K2 Metabolites

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., KAMAO, KAMAO., M., M., MIMATSU, MIMATSU., S., S., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2007 9 1, : : Proceedings of 29th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

Vitamin K content of foods and dietary vitamin K intake in Japanese young women

Kamao, M., Suhara, Y., Tsugawa, N., Uwano, M., Yamaguchi, N., Uenishi, K., Ishida, H., Sasaki, S. & Okano, T., 2007 12 1, : : Journal of nutritional science and vitaminology. 53, 6, p. 464-470 7 p.

研究成果: Article

70 引用 (Scopus)
2006

Biological Activities of 2 -Substituted Analogues of 1 ,25-Dihydroxyvitamin D3 in Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation

TAKAHASHI, TAKAHASHI., E, E., E., E., NAKAGAWA, NAKAGAWA., K., K., SUHARA, SUHARA., Y., Y., KITTAKA, KITTAKA., A., A., NIHEI, NIHEI., KONNO, KONNO., TAKAYAMA, TAKAYAMA., H., H., OKANO, OKANO. & T., T., 2006 11 1, : : Biological & Pharmaceutical Bulletin. 29, p. 2246-2250

研究成果: Article

22 引用 (Scopus)

Biological activities of 2α-substituted analogues of 1α,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation

Takahashi, E., Nakagawa, K., Suhara, Y., Kittaka, A., Nihei, K. I., Konno, K., Takayama, H., Ozono, K. & Okano, T., 2006 11, : : Biological and Pharmaceutical Bulletin. 29, 11, p. 2246-2250 5 p.

研究成果: Article

22 引用 (Scopus)

Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines

Suhara, Y., Murakami, A., Nakagawa, K., Mizuguchi, Y. & Okano, T., 2006 10 1, : : Bioorganic and Medicinal Chemistry. 14, 19, p. 6601-6607 7 p.

研究成果: Article

17 引用 (Scopus)

Comparative Uptake, Metabolism and Utilization of Menaquinone-4 and Phylloquinone in Human Cultured Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., NAKAGAWA, NAKAGAWA., K., K., MIZUGUCHI, MIZUGUCHI., OKANO, OKANO. & T., T., 2006 8 1, : : Bioorganic & Medicinal Chemistry. 14, p. 6601-6607

研究成果: Article

17 引用 (Scopus)

Development of a Biologically Active Fluorescent-labeled Vitamin K and Monitoring of the Subcellular Distribution in Cells

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., SHIMOMURA, SHIMOMURA., NAKAGAWA, NAKAGAWA., K., K., OKANO, OKANO. & T., T., 2006 9 1, : : Proceedings of 28th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

Efficient synthesis of carbopeptoid oligomers: insight into mimicry of β-peptide

Suhara, Y., Kurihara, M., Kittaka, A. & Ichikawa, Y., 2006 8 21, : : Tetrahedron. 62, 34, p. 8207-8217 11 p.

研究成果: Article

13 引用 (Scopus)

Efficient Synthesis of Carbopeptoid Oligomers: Insight into Mimicry of -Peptide

SUHARA, SUHARA., Y., Y., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A. & ICHIKAWA, ICHIKAWA., 2006 8 1, : : Tetrahedron. 62, p. 8207-8217

研究成果: Article

13 引用 (Scopus)
1 引用 (Scopus)

Probing a Water Channel near the A-Ring of Receptor-Bound 1 ,25-Dihydroxyvitamin D3 with Selected 2 -Substituted Analogues

HOURAI, HOURAI., S, S., S., S., FUJISHIMA, FUJISHIMA., T., T., KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y. 5, Y. ., TAKAYAMA, TAKAYAMA., H., H., ROCHEL, ROCHEL., N., N., MORAS, MORAS. & D., D., 2006 7 1, : : Journal of Medicinal Chemistry. 49, p. 5199-5205

研究成果: Article

91 引用 (Scopus)

Probing a water channel near the A-ring of receptor-bound 1α,25-dihydroxyvitamin D3 with selected 2α-substituted analogues

Hourai, S., Fujishima, T., Kittaka, A., Suhara, Y., Takayama, H., Rochel, N. & Moras, D., 2006 8 24, : : Journal of Medicinal Chemistry. 49, 17, p. 5199-5205 7 p.

研究成果: Article

91 引用 (Scopus)

Vitamin K status of healthy Japanese women: Age-related vitamin K requirement for γ-carboxylation of osteocalcin

Tsugawa, N., Shiraki, M., Suhara, Y., Kamao, M., Tanaka, K. & Okano, T., 2006 2 1, : : American Journal of Clinical Nutrition. 83, 2, p. 380-386 7 p.

研究成果: Article

公開
86 引用 (Scopus)

Vitamin K Status of Healthy Japanese Women; Age-related Vitamin K Requirement for gamma-Carboxylation of Osteocalcin

TSUGAWA, TSUGAWA., N., N., SHIRAKI, SHIRAKI., M., M., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., TANAKA, TANAKA., K., K., OKANO, OKANO. & T., T., 2006 1 1, : : The American Society for Nutrution. 83, p. 380-386

研究成果: Article

86 引用 (Scopus)
101 引用 (Scopus)

Determination of 25-Hydroxyvitamin D in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

TSUGAWA, TSUGAWA., N., N., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., M., M., OKANO, OKANO. & T., T., 2005 5 1, : : Analytical Chemistry. 77, p. 3001-3007

研究成果: Article

101 引用 (Scopus)
55 引用 (Scopus)

Metabolism of 2 -Propoxy-1 ,25-dihydroxyvitamin D3 and 2 -(3-Hydroxypropoxy)-1 ,25 -dihydroxyvitamin D3 by Human CYP27A1 and CYP24A1.

ABE, ABE., D., D., SAKAKI, SAKAKI., T., T., KUSUDO, KUSUDO., KITTAKA, KITTAKA., A., A., SAITO, SAITO., N., N., SUHARA, SUHARA., Y., Y., FUJISHIMA, FUJISHIMA., TAKAYAMA, TAKAYAMA., H. HAMAMOTO, H. HAMAMOTO., H, H., KAMAKURA, KAMAKURA., M, M. & K., OHTA. M. INOUYE., 2005 6 1, : : Drug Metabolism and Disposition. 33, p. 778-784

研究成果: Article

Metabolism of 2α-propoxy-1α,25-dihydroxyvitamin D3 and 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1

Abe, D., Sakaki, T., Kusudo, T., Kittaka, A., Saito, N., Suhara, Y., Fujishima, T., Takayama, H., Hamamoto, H., Kamakura, M., Ohta, M. & Inouye, K., 2005 6 1, : : Drug Metabolism and Disposition. 33, 6, p. 778-784 7 p.

研究成果: Article

25 引用 (Scopus)

Method for the Detection of Vitamin K Homologues in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry

SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2005 2 1, : : Analytical Chemistry. 77, p. 757-763

研究成果: Article

85 引用 (Scopus)
85 引用 (Scopus)

Vitamin K Circulating Levels and Associations with Bone Metabolism in Healthy Japanese Women

TSUGAWA, TSUGAWA., N., N., SHIRAKI, SHIRAKI., M., M., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., TANAKA, TANAKA., K., K., OKANO, OKANO. & T., T., 2005 9 1, : : Proceedings of 27th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article

Design and Efficient Synthesis of 2alpha-(omega-Hydroxyalkoxy)-1alpha,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity

SAITO, SAITO., N., N., SUHARA, SUHARA., Y., Y., KURIHARA, KURIHARA., M., M., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., TAKAYANAGI, TAKAYANAGI., H., H., KOZONO, KOZONO., MATSUMOTO, MATSUMOTO., OHMORI, OHMORI., MIYATA, MIYATA. & A., N. TAKAYAMA. H. KITTAKA., 2004 9 1, : : Journal of Organic Chemistry. 69, p. 7463-7471

研究成果: Article

69 引用 (Scopus)

Design and efficient synthesis of 2α-(ω-hydroxyalkoxy)- 1α,25-dihydroxyvitamin D3 analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity

Saito, N., Suhara, Y., Kurihara, M., Fujishima, T., Honzawa, S., Takayanagi, H., Kozono, T., Matsumoto, M., Ohmori, M., Miyata, N., Takayama, H. & Kittaka, A., 2004 10 29, : : Journal of Organic Chemistry. 69, 22, p. 7463-7471 9 p.

研究成果: Article

69 引用 (Scopus)

Synthesis of Novel 1 ,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate

SUHARA, SUHARA., Y., Y., ONO, ONO., K., K., YOSHIDA, YOSHIDA., A., A., FUJISHIMA, FUJISHIMA., T., T., SAITO, SAITO., N., N., HONZAWA, HONZAWA., S., S., KISHIMOTO, KISHIMOTO., SUGIURA, SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA. & A., H. KITTAKA., 2004 1 1, : : Heterocycles. 62, p. 426-436

研究成果: Article

Synthesis of novel 1α,25-dihydroxy-19-norvitamin D3 with an amide conjugate

Suhara, Y., Ono, K., Yoshida, A., Fujishima, T., Saito, N., Honzawa, S., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2004 1 1, : : Heterocycles. 62, p. 423-436 14 p.

研究成果: Article

4 引用 (Scopus)
2003

2alpha -(3-Hydroxypropyl)- and 2 alpha-(3-Hydroxypropyl)-1alpha ,25-dihydroxyvitamin D3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets

KITTAKA, KITTAKA., A., A., KURIHARA, KURIHARA., M., M., PLEG, PLEG., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA. & H., H., 2003 3 1, : : Chemical & Pharmaceutical Bulletin. 51, p. 357-358

研究成果: Article

28 引用 (Scopus)
公開
28 引用 (Scopus)

Concise Synthesis and Biological Activities of 2alpha-Alkyl- and 2 alpha-( omega-Hydroxyalkyl)-20-epi-1 alpha,25-dihydroxyvitamin D3

HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., SAITO, SAITO., N., N., KISHIMOTO, KISHIMOTO., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M.:SUGIURA, M. SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA., H., H. & A., KITTAKA., 2003 10 1, : : Bioorganic & Medicinal Chemistry. 13, p. 3503-3506

研究成果: Article

24 引用 (Scopus)

Concise synthesis and biological activities of 2α-alkyl- and 2α-(ω-hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D 3

Honzawa, S., Suhara, Y., Nihei, K. I., Saito, N., Kishimoto, S., Fujishima, T., Kurihara, M., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 10 20, : : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3503-3506 4 p.

研究成果: Article

24 引用 (Scopus)

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs

TAKAYAMA, TAKAYAMA., H., H., KITTAKA, KITTAKA., A., A., FUJISHIMA, FUJISHIMA., T., T., SUHARA, SUHARA. & Y., Y., 2003 5 1, : : Recent Results in Cancer Research164 (Vitamin D Analogs in Cancer Prevention and Therapy). 164, p. 289-317

研究成果: Article

25 引用 (Scopus)
25 引用 (Scopus)

Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2alpha - and 2beta -Alkylated 1alpha ,25-Dihydroxy-19-norvitamin D3 Analogues

YOSHIDA, YOSHIDA., A., A., ONO, ONO., K., K., SUHARA, SUHARA., Y., Y., SAITO, SAITO., N., N., TAKAYAMA, TAKAYAMA., H., H. & KITTAKA, KITTAKA., 2003 6 1, : : Synlett. 8, p. 1175-1179

研究成果: Article

Efficient and convergent coupling route for the short-step synthesis of enantiopure 2α- and 2β-alkylated 1α,25-dihydroxy-19-norvitamin D3 analogues

Yoshida, A., Ono, K., Suhara, Y., Saito, N., Takayama, H. & Kittaka, A., 2003 1 1, : : Synlett. 8, p. 1175-1179 5 p.

研究成果: Article

28 引用 (Scopus)

Efficient Synthesis of 2-Modified 1 alpha,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells

ONO, ONO., K., K., YOSHIDA, YOSHIDA., A., A., SAITO, SAITO., N., N., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., KISHIMOTO, KISHIMOTO., SUGIURA, SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA. & A., H. KITTAKA., 2003 8 1, : : Journal of Organic Chemistry. 68, p. 7407-7415

研究成果: Article

98 引用 (Scopus)

Efficient synthesis of 2-modified 1α,25-dihydroxy-19-norvitamin D3 with Julia olefination: High potency in induction of differentiation on HL-60 cells

Ono, K., Yoshida, A., Saito, N., Fujishima, T., Honzawa, S., Suhara, Y., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 9 19, : : Journal of Organic Chemistry. 68, 19, p. 7407-7415 9 p.

研究成果: Article

98 引用 (Scopus)

Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species

Oka, S., Tsuchie, A., Tokumura, A., Muramatsu, M., Suhara, Y., Takayama, H., Waku, K. & Sugiura, T., 2003 6 1, : : Journal of Neurochemistry. 85, 6, p. 1374-1381 8 p.

研究成果: Article

85 引用 (Scopus)
2002

Design and Efficient Syntheses of New Stable 1 alpha,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., ONO, ONO., K., K., FUJISHIMA, FUJISHIMA., T., T., YOSHIDA, YOSHIDA., TAKAYAMA, TAKAYAMA. & H., H., 2002 12 1, : : Bioorganic & Medicinal Chemistry Letters. 12, p. 3533-3536

研究成果: Article

17 引用 (Scopus)

Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D3 analogues containing amide bond

Suhara, Y., Kittaka, A., Ono, K., Kurihara, M., Fujishima, T., Yoshida, A. & Takayama, H., 2002 12 1, : : Bioorganic and Medicinal Chemistry Letters. 12, 24, p. 3533-3536 4 p.

研究成果: Article

17 引用 (Scopus)

Oligomers of glycamino acid

Suhara, Y., Yamaguchi, Y., Collins, B., Schnaar, R. L., Yanagishita, M., Hildreth, J. E. K., Shimada, I. & Ichikawa, Y., 2002 4 18, : : Bioorganic and Medicinal Chemistry. 10, 6, p. 1999-2013 15 p.

研究成果: Article

56 引用 (Scopus)
公開
5 引用 (Scopus)

Synthesis and Testing of 2 alpha-Modified 1 alpha,25-Dihydroxyvitamin D3 Analogues with a Double Side Chain: Marked Cell Differenciation Activity

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., KISHIMOTO, KISHIMOTO., S., S., CALVERLEY, CALVERLEY., M., J., FUJISHIMA, FUJISHIMA., T., T., SAITO, SAITO., N., N., SUGIURA, SUGIURA., WAKU, WAKU., K., K., TAKAYAMA, TAKAYAMA. & H., H., 2002 12 1, : : Bioorganic & Medicinal Chemistry Letters. 12, p. 3255-3258

研究成果: Article

26 引用 (Scopus)

Synthesis and testing of 2α-Modified 1α,25-Dihydroxyvitamin D3 analogues with a double side chain: Marked cell differentiation activity

Suhara, Y., Kittaka, A., Kishimoto, S., Calverley, M. J., Fujishima, T., Saito, N., Sugiura, T., Waku, K. & Takayama, H., 2002 11 18, : : Bioorganic and Medicinal Chemistry Letters. 12, 22, p. 3255-3258 4 p.

研究成果: Article

26 引用 (Scopus)
2001

Efficient and Versatile Synthesis of Novel 2alpha -Substituted 1alpha ,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors

SUHARA, SUHARA., Y, Y., NIHEI, NIHEI., K., K., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A., YAMAGUCHI, YAMAGUCHI., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., MIYATA, MIYATA., N., N., TAKAYAMA, TAKAYAMA. & H., H., 2001 11 1, : : Journal of Organic Chemistry. 66, p. 8760-8771

研究成果: Article

94 引用 (Scopus)

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

Suhara, Y., Nihei, K. I., Kurihara, M., Kittaka, A., Yamaguchi, K., Fujishima, T., Konno, K., Miyata, N. & Takayama, H., 2001 12 28, : : Journal of Organic Chemistry. 66, 26, p. 8760-8771 12 p.

研究成果: Article

94 引用 (Scopus)

Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Suhara, Y., Nakane, S., Arai, S., Takayama, H., Waku, K., Ishima, Y. & Sugiura, T., 2001 8 6, : : Bioorganic and Medicinal Chemistry Letters. 11, 15, p. 1985-1988 4 p.

研究成果: Article

11 引用 (Scopus)