Yoshitomo Suhara

2023

Synthesis of new vitamin K derivatives with a ketone group at the C-1′ position of the side chain and their conversion to menaquinone-4

Furukawa, N., Chen, X., Asano, S., Matsumoto, M., Wu, Y., Murata, K., Takeuchi, A., Tode, C., Homma, T., Koharazawa, R., Usami, K., Tie, J. K., Hirota, Y. & Suhara, Y., 2023 3月 15, In: Journal of Molecular Structure. 1276, 134614.

研究成果: Article › 査読

Open Access

2022

Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation

Chen, X., Furukawa, N., Jin, D. Y., Liu, Y., Stafford, D. W., Williams, C. M., Suhara, Y. & Tie, J. K., 2022 5月, In: FEBS Journal. 289, 9, p. 2613-2627 15 p.

研究成果: Article › 査読

2021

A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase

Chen, X., Liu, Y., Furukawa, N., Jin, D. Y., Paul Savage, G., Stafford, D. W., Suhara, Y., Williams, C. M. & Tie, J. K., 2021 3月, In: Journal of Thrombosis and Haemostasis. 19, 3, p. 689-700 12 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Development of Selective TGR5 Ligands Based on the 5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalene Skeleton

Terui, R., Yanase, Y., Yokoo, H., Suhara, Y., Makishima, M., Demizu, Y. & Misawa, T., 2021 2月 4, In: ChemMedChem. 16, 3, p. 458-462 5 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

2020

Study on structure–activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity

Yoshimura, H., Hirota, Y., Soda, S., Okazeri, M., Takagi, Y., Takeuchi, A., Tode, C., Kamao, M., Osakabe, N. & Suhara, Y., 2020 4月 15, In: Bioorganic and Medicinal Chemistry Letters. 30, 8, 127059.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

2019

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 10月 11, In: Molecules. 24, 20, 3667.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 11月 26, In: Molecules. 24, 23, 4316.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

UBIAD1 plays an essential role in the survival of pancreatic Acinar cells

Nakagawa, K., Fujiwara, K., Nishimura, A., Murakami, C., Kawamoto, K., Ichinose, C., Kunitou, Y., Suhara, Y., Okano, T. & Hasegawa, H., 2019 4月 2, In: International journal of molecular sciences. 20, 8, 1971.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

2018

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 7月, In: PLoS ONE. 13, 7, e0201203.

研究成果: Article › 査読

Open Access

17 被引用数 (Scopus)

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

HirotaI, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 10月, In: PLoS ONE. 13, 10, e0199856.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

2017

Nongenomic effects of 1α,25-dihydroxyvitamin D₃ on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 1月 29, In: Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Substitution at the C-3 position of catechins has an influence on the binding affinities against serum albumin

Ikeda, M., Ueda-Wakagi, M., Hayashibara, K., Kitano, R., Kawase, M., Kaihatsu, K., Kato, N., Suhara, Y., Osakabe, N. & Ashida, H., 2017 2月 1, In: Molecules. 22, 2, 314.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimura, K., Hirota, Y., Kuwahara, S., Takeuchi, A., Tode, C., Wada, A., Osakabe, N. & Suhara, Y., 2017 3月 23, In: Journal of Medicinal Chemistry. 60, 6, p. 2591-2596 6 p.

研究成果: Article › 査読

Open Access

13 被引用数 (Scopus)

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 11月 1, In: Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

2016

A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice

Kamio, N., Suzuki, T., Watanabe, Y., Suhara, Y. & Osakabe, N., 2016 2月 1, In: Free Radical Biology and Medicine. 91, p. 256-263 8 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Saito, A., Nakazato, R., Suhara, Y., Shibata, M., Fukui, T., Ishii, T., Asanuma, T., Mochizuki, K., Nakayama, T. & Osakabe, N., 2016 6月 1, In: Journal of Nutritional Biochemistry. 32, p. 107-114 8 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

2015

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 9月 16, In: PLoS ONE. 10, 9, e0137809.

研究成果: Article › 査読

Open Access

33 被引用数 (Scopus)

Functional characterization of the vitamin K₂ biosynthetic enzyme UBIAD1

Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 4月 15, In: PLoS ONE. 10, 4, e0125737.

研究成果: Article › 査読

40 被引用数 (Scopus)

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 9月 10, In: Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

YY1 positively regulates human UBIAD1 expression

Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 5月 1, In: Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

2014

Vitamin K₂ biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice

Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014 8月 15, In: PLoS ONE. 9, 8, e104078.

研究成果: Article › 査読

34 被引用数 (Scopus)

2013

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11

Edson, K. Z., Prasad, B., Unadkat, J. D., Suhara, Y., Okano, T., Peter Guengerich, F. & Rettie, A. E., 2013 11月 19, In: Biochemistry. 52, 46, p. 8276-8285 10 p.

研究成果: Article › 査読

62 被引用数 (Scopus)

Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance

Li, Q., Qi, J., Wu, Y., Kiyota, H., Tanaka, K., Suhara, Y., Ohrui, H., Suzuki, Y., Vavricka, C. J. & Gao, G. F., 2013, In: Journal of Virology. 87, 18, p. 10016-10024 9 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

Menadione (vitamin K₃) is a catabolic product of oral phylloquinone (vitamin K₁) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K₂) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 11月 15, In: Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

研究成果: Article › 査読

88 被引用数 (Scopus)

2012

Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Suhara, Y., Hanada, N., Okitsu, T., Sakai, M., Watanabe, M., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2012 2月 23, In: Journal of Medicinal Chemistry. 55, 4, p. 1553-1558 6 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities

SUHARA, SUHARA., Y., Y., HANADA, HANADA., N., N., OKITSU, OKITSU., T., T., SAKAI, SAKAI., M., M., WATANABE, WATANABE., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA. & T., H. . OKANO., 2012 1月 17, In: Journal of Medicinal Chemistry. 55, p. 1553-1558

研究成果: Article › 査読

12 被引用数 (Scopus)

2011

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

Suhara, Y., Watanabe, M., Motoyoshi, S., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2011 7月 14, In: Journal of Medicinal Chemistry. 54, 13, p. 4918-4922 5 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

SUHARA, SUHARA., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 12月 1, In: Default journal. p. 177-177

研究成果: Article › 査読

21 被引用数 (Scopus)

Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor Agonists: Insight into the Biological Role of the Side Chain Part of Vitamin K

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 5月 27, In: Jornal of Medicinal Chemistry. 54, p. 4918-4922

研究成果: Article › 査読

21 被引用数 (Scopus)

Synthesis of novel vitamin K₂ analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists

Suhara, Y., Watanabe, M., Nakagawa, K., Wada, A., Ito, Y., Takeda, K., Takahashi, K. & Okano, T., 2011 6月 23, In: Journal of Medicinal Chemistry. 54, 12, p. 4269-4273 5 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Synthesis of Novel Vitamin K2 Analogues with Modification at the ω-Terminal Position and their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., NAKAGWA, NAKAGWA., K., K., WADA, WADA., A., A., ITO, ITO., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., OKANO, OKANO. & T., T., 2011 5月 11, In: Jornal of Medicinal Chemistry. 54, p. 4269-4273

研究成果: Article › 査読

11 被引用数 (Scopus)

2010

Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives

Wada, A., Wang, F., Suhara, Y., Yamano, Y., Okitsu, T., Nakagawa, K. & Okano, T., 2010 8月 15, In: Bioorganic and Medicinal Chemistry. 18, 16, p. 5795-5806 12 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Identification of UBIAD1 as a Novel Human Menaquinone-4 Biosynthesis Enzyme

NAKAGAWA, NAKAGAWA., K, K., K., K., HIROTA, HIROTA., Y., Y., SAWADA, SAWADA., N., N., YUGE, YUGE., WATANABE, WATANABE., M., M., UCHINO, UCHINO., OKUDA, OKUDA., SHIMOMURA, SHIMOMURA., SUHARA, SUHARA., OKANO, OKANO. & T., T., 2010 11月 1, In: Nature. 468, p. 117-121

研究成果: Article › 査読

231 被引用数 (Scopus)

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Nakagawa, K., Hirota, Y., Sawada, N., Yuge, N., Watanabe, M., Uchino, Y., Okuda, N., Shimomura, Y., Suhara, Y. & Okano, T., 2010 11月 4, In: Nature. 468, 7320, p. 117-121 5 p.

研究成果: Article › 査読

231 被引用数 (Scopus)

Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines

Suhara, Y., Wada, A., Tachibana, Y., Watanabe, M., Nakamura, K., Nakagawa, K. & Okano, T., 2010 5月 1, In: Bioorganic and Medicinal Chemistry. 18, 9, p. 3116-3124 9 p.

研究成果: Article › 査読

17 被引用数 (Scopus)

Structure-activity Relationships in the Conversion of Vitamin K Analogues into Menaquinone-4. Substrates Essential to the Synthesis of Menaquinone-4 in Cultured Human Cell Lines.

SUHARA, SUHARA., Y, Y., Y., Y., WADA, WADA., A., A., TACHIBANA, TACHIBANA., WATANABE, WATANABE., M., M., NAKAMURA, NAKAMURA., K., K., NAKAGAWA, NAKAGAWA., OKANO, OKANO. & T., T., 2010 3月 1, In: Bioorganic & Medicinal Chemistry. 18, p. 3116-3124

研究成果: Article › 査読

17 被引用数 (Scopus)

2009

Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells

Suhara, Y., Wada, A. & Okano, T., 2009 2月 15, In: Bioorganic and Medicinal Chemistry Letters. 19, 4, p. 1054-1057 4 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Synthesis of 2 -Propoxy-1 ,25- dihydroxyvitamin D3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A1

SAITO, SAITO., N, N., N., N., SUHARA, SUHARA., Y., Y., ABE, ABE., D., D., KUSUDO, KUSUDO., T., T., OHTA, OHTA., M., M., SAKAKI, SAKAKI., HONZAWA, HONZAWA., S., S., FUJISHIMA, FUJISHIMA., KITTAKA, KITTAKA. & A., A., 2009 3月 1, In: Bioorganic & Medicinal Chemistry. 17, p. 4296-4301

研究成果: Article › 査読

22 被引用数 (Scopus)

Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D₃ and comparison of its metabolism by human CYP24A1 and rat CYP24A1

Saito, N., Suhara, Y., Abe, D., Kusudo, T., Ohta, M., Yasuda, K., Sakaki, T., Honzawa, S., Fujishima, T. & Kittaka, A., 2009 7月 1, In: Bioorganic and Medicinal Chemistry. 17, 13, p. 4296-4301 6 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

2008

Conversion of phylloquinone (vitamin K₁) into menaquinone-4 (vitamin K₂) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice

Okano, T., Shimomura, Y., Yamane, M., Suhara, Y., Kamao, M., Sugiura, M. & Nakagawa, K., 2008 4月 25, In: Journal of Biological Chemistry. 283, 17, p. 11270-11279 10 p.

研究成果: Article › 査読

194 被引用数 (Scopus)

Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice: TWO POSSIBLE ROUTE FOR MENAQUINONE-4 ACCUMULATION IN CEREBRA OF MICE

OKANO, OKANO., T, T., T., T., SHIMOMURA, SHIMOMURA., Y., Y., YAMANE, YAMANE., M., M., SUHARA, SUHARA., KAMAO, KAMAO., SUGIURA, SUGIURA., NAKAGAWA, NAKAGAWA. & K., K., 2008 11月 1, In: Journal of Biological Chemistry. 283, p. 11270-11279

研究成果: Article › 査読

194 被引用数 (Scopus)

Conversion of Vitamin K Analogues to Menaquinone-4 in Osteoblastic Cells

SUHARA, SUHARA., Y, Y., Y., Y., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 9月 1, In: Proceedings of 30th Annual Meeting of the American Society for Bone and Mineral Research.

研究成果: Article › 査読

Design and synthesis of biologically active analogues of vitamin K₂: Evaluation of their biological activities with cultured human cell lines

Suhara, Y., Hirota, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 3月 15, In: Bioorganic and Medicinal Chemistry. 16, 6, p. 3108-3117 10 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Design and Synthesis of Biologically Active Analogues of Vitamin K2: Evaluation of their Biological Activities with Cultured Human Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., HIROTA, HIROTA., NAKAGAWA, NAKAGAWA., K., K., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 1月 1, In: Bioorganic & Medicinal Chemistry. 16, p. 3108-3117

研究成果: Article › 査読

13 被引用数 (Scopus)

Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women

Tsugawa, N., Shiraki, M., Suhara, Y., Kamao, M., Ozaki, R., Tanaka, K. & Okano, T., 2008 1月, In: Journal of Bone and Mineral Metabolism. 26, 1, p. 79-85 7 p.

研究成果: Article › 査読

64 被引用数 (Scopus)

Synthesis and development of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution

Suhara, Y., Abe, S., Murakami, A., Shimomura, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 9月 8, In: Tetrahedron. 64, 37, p. 8789-8796 8 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

2007

Determination of Fat-Soluble Vitamins in Human Plasma, Breast Milk and Food Samples: Application in Nutrition Survey for Establishment of "Dietary Reference Intakes for Japanese"

KAMAO, KAMAO., M, M., M., M., TSUGAWA, TSUGAWA., N., N., SUHARA, SUHARA., Y., Y., OKANO, OKANO. & T., T., 2007 3月 1, In: Journal of Health Science. 53, p. 257-262

研究成果: Article › 査読

12 被引用数 (Scopus)

Efficient Synthesis and Biological Evaluation of -Oxygenated Analogues of Vitamin K2: Study of Modification and Structure-activity Relationship of Vitamin K2 Metabolites

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2007 2月 1, In: Bioorganic & Medicinal Chemistry Letters. 17, p. 1622-1625

研究成果: Article › 査読

9 被引用数 (Scopus)

Efficient synthesis and biological evaluation of ω-oxygenated analogues of vitamin K₂: Study of modification and structure-activity relationship of vitamin K₂ metabolites

Suhara, Y., Murakami, A., Kamao, M., Mimatsu, S., Nakagawa, K., Tsugawa, N. & Okano, T., 2007 3月 15, In: Bioorganic and Medicinal Chemistry Letters. 17, 6, p. 1622-1625 4 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Quantification of fat-soluble vitamins in human breast milk by liquid chromatography-tandem mass spectrometry

Kamao, M., Tsugawa, N., Suhara, Y., Wada, A., Mori, T., Murata, K., Nishino, R., Ukita, T., Uenishi, K., Tanaka, K. & Okano, T., 2007 11月 15, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 859, 2, p. 192-200 9 p.

研究成果: Article › 査読

94 被引用数 (Scopus)

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