A directional electron transfer regulator based on heme-chain architecture in the small tetraheme cytochrome c from Shewanella oneidensis

Erisa Harada, Jiro Kumagai, Kiyoshi Ozawa, Shinichiro Imabayashi, Alexandre S. Tsapin, Kenneth H. Nealson, Terrance E. Meyer, Michael A. Cusanovich, Hideo Akutsu

研究成果査読

32 被引用数 (Scopus)

抄録

The macroscopic and microscopic redox potentials of the four hemes of the small tetraheme cytochrome c from Shewanella oneidensis were determined. The microscopic redox potentials show that the order of reduction is from hemes in the C-terminal domain (hemes 3 and 4) to the N-terminal domain (heme 1), demonstrating the polarization of the tetraheme chain during reduction. This makes heme 4 the most efficient electron delivery site. Furthermore, multi-step reduction of other redox centers through either heme 4 or heme 3 is shown to be possible. This has provided new insights into the two-electron reduction of the flavin in the homologous flavocytochrome c-fumarate reductase.

本文言語English
ページ(範囲)333-337
ページ数5
ジャーナルFEBS Letters
532
3
DOI
出版ステータスPublished - 2002 12 18
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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