A Gain-of-function mutation in gating of Corynebacterium glutamicum NCgl1221 causes constitutive glutamate secretion

Yoshitaka Nakayama, Kenjiro Yoshimura, Hidetoshi Iida

研究成果: Comment/debate

16 引用 (Scopus)

抜粋

The A-to-V mutation at position 111 (A111V) in the mechanosensitive channel NCgl1221 (MscCG) causes constitutive glutamate secretion in Corynebacterium glutamicum. Patch clamp experiments revealed that NCgl1221 (A111V) had a significantly smaller gating threshold than the wild-type counterpart and displayed strong hysteresis, suggesting that the gain-of-function mutation in the gating of NCgl1221 leads to the oversecretion of glutamate.

元の言語English
ページ(範囲)5432-5434
ページ数3
ジャーナルApplied and Environmental Microbiology
78
発行部数15
DOI
出版物ステータスPublished - 2012 8 1

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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