A microfluidic model of microbubble lodging in small arteriole bifurcations

Joseph L. Bull, Andrés J. Calderón, Yunseok Heo, Dongeun Huh, Futai Nobuyuki, Shuichi Takayama, J. Brian Fowlkes

研究成果: Conference contribution

抄録

Lodging of cardiovascular gas bubbles is investigated in a microfluidic model of small arteriole bifurcations. This work is motivated by a novel gas embolotherapy technique for the potential treatment of cancer by tumor infarction and by air embolism. The experimental model arteriole bifurcations were constructed from a transparent elastomer, poly(dimethylsiloxane), using soft lithography. A single air bubble was suspended in water within the parent tube of the bifurcation and a specified driving pressure was imposed via constant elevation reservoirs that were open to atmospheric pressure. The driving pressure and bubble size were varied, and their effects on the bubble lodging were assessed. These findings may be useful in developing strategies for microbubble delivery in gas embolotherapy.

本文言語English
ホスト出版物のタイトル2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
ページ290-291
ページ数2
DOI
出版ステータスPublished - 2005
外部発表はい
イベント2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
継続期間: 2005 5月 122005 5月 15

出版物シリーズ

名前2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
2005

Conference

Conference2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
国/地域United States
CityOahu, HI
Period05/5/1205/5/15

ASJC Scopus subject areas

  • 工学(全般)

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