抄録
Mild and highly chemoselective a-iodination reactions of N-allylic carboxamides and lactams are reported. N-Allylic amides and lactams reacted with I2 and 2,6-lutidine at room temperature to give α-iodo amides and lactams in moderate to good yields. The exclusive α-iodination of N-allylic amides having another acidic hydrogen in the molecule proceeded under these conditions. The iodides obtained were converted to the bicyclic lactam or the β-lactam derivatives with high stereoselectivity by a radical iodine atom-transfer reaction or a nucleophilic substitution reaction.
本文言語 | English |
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ページ(範囲) | 7161-7165 |
ページ数 | 5 |
ジャーナル | Journal of Organic Chemistry |
巻 | 60 |
号 | 22 |
DOI | |
出版ステータス | Published - 1995 11月 1 |
外部発表 | はい |
ASJC Scopus subject areas
- 有機化学