A Plasma-Polymerized Film for Surface Plasmon Resonance Immunosensing

Runa Nakamura, Hitoshi Muguruma, Kazunori Ikebukuro, Satoshi Sasaki, Ryohei Nagata, Isao Karube, Henrik Pedersen

研究成果: Article査読

85 被引用数 (Scopus)

抄録

We propose a novel ethylenediamine plasma-polymerized film matrix that is deposited on gold surfaces for use in surface plasmon resonance immunosensing. The films formed on the gold surfaces are extremely thin (∼100 nm), are homogeneous, demonstrate good adhesion, have a flat profile, and incorporate amino groups to introduce a chemical functionality. A sensor chip made with the film has many advantages when compared with conventionally used designs such as carboxylated dextran hydrogels. For example, a sensor chip made with the film shows a better sensor response than a conventional design partly because antibodies are densely and two-dimensionally immobilized onto the surface of the plasma-polymerized film.

本文言語English
ページ(範囲)4649-4652
ページ数4
ジャーナルAnalytical Chemistry
69
22
DOI
出版ステータスPublished - 1997 11 15
外部発表はい

ASJC Scopus subject areas

  • 分析化学

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