A synthetic approach to aromatic aminoglycoside as a neamine mimic

Ryo Inoue, Sho Matsuda, Yoshiki Oda, Hirofumi Ooyama, Akihiro Yoshida, Keita Hamasaki, Takashi Yamanoi

研究成果: Article

抜粋

This paper describes the synthetic approach to an aromatic a-glycoside as a mimic of neamine, which is a common core structure of some aminoglycoside antibiotics. We achieved the synthesis of the protected precursor of the neamine mimic, 4-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyloxy)-1,3- phenylenediamine, from N-acetyl-D-glucosamine and 2,4-diaminophenol as the starting materials using a glycosylation technique.

元の言語English
ページ(範囲)1335-1343
ページ数9
ジャーナルHeterocycles
84
発行部数2
DOI
出版物ステータスPublished - 2012

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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  • これを引用

    Inoue, R., Matsuda, S., Oda, Y., Ooyama, H., Yoshida, A., Hamasaki, K., & Yamanoi, T. (2012). A synthetic approach to aromatic aminoglycoside as a neamine mimic. Heterocycles, 84(2), 1335-1343. https://doi.org/10.3987/COM-11-S(P)69