A synthetic replica having surface morphology of decellularized tissue regulated orientation and shape of cells

Tsuvoshi Kimura, Mako Kobayashi, Yoshihide Hashimoto, Toshiya Fujisato, Naoko Nakamura, Akio Kisliida

研究成果: Conference contribution

抜粋

Decellularized tissues, which are extracellular matrix assembly prepared from living tissue, are tried to apply for regenerative medicine and to be used as biomaterials because of the good biocompatibility. Recently, many researchers are challenging to resolve its mechanism, but it is still unclear. Previously, our group also reported that decellularized tissues were prepared by high hydrostatic pressure (HHP) technology and they showed good biocompatibility [1]. Especially, decellularized aorta showed good patency and early endothelialization for in vivo vascular replacement [2].One possible reason is that HHP decellularized luminal surface remains the similar morphology to native aortic lumenal surface. In this study, we investigated the surface morphology of aortic lumen prepared by various decellularization methods using HHP and SDS, and synthetic replicas were prepared by a transferring method using poly(dimethyl siloxane) (PDMS). The endothelial cell behavior on them was investigated (Figure 1).

元の言語English
ホスト出版物のタイトルSociety for Biomaterials Annual Meeting and Exposition 2019
ホスト出版物のサブタイトルThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
出版者Society for Biomaterials
ページ数1
ISBN(電子版)9781510883901
出版物ステータスPublished - 2019 1 1
イベント42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
継続期間: 2019 4 32019 4 6

出版物シリーズ

名前Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
40
ISSN(印刷物)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
United States
Seattle
期間19/4/319/4/6

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • これを引用

    Kimura, T., Kobayashi, M., Hashimoto, Y., Fujisato, T., Nakamura, N., & Kisliida, A. (2019). A synthetic replica having surface morphology of decellularized tissue regulated orientation and shape of cells. : Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; 巻数 40). Society for Biomaterials.