Aberrant control of motoneuronal excitability in amyotrophic lateral sclerosis: Excitatory glutamate/D-serine vs. inhibitory glycine/γ- aminobutanoic acid (GABA)

Jumpei Sasabe, Sadakazu Aiso

研究成果: Review article

14 引用 (Scopus)

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The mechanism underlying selective motoneuronal loss in amyotrophic lateral sclerosis (ALS) remains uncertain. The pathogenesis appears to be a complex and multifactorial process. Glutamate excitotoxicity to motoneuron is one of the most intensely investigated targets for the treatment of ALS, and excessive motoneuronal excitation by glutamate through ionotropic glutamate receptors has been mainly demonstrated. However, development of clinically effective drug targeting glutamate is sometimes difficult, because some aspects of glutamergic signals also could be beneficial, as the injured neurons attempt to recruit endogenous recovery. This review is focused on identifying other mechanisms of imbalanced excitation in ALS motoneurons including excitation-modulating D-serine and inhibitory glycine/GABA. Further, validation of these mechanisms might ultimately lead us to new therapeutic targets for ALS.

元の言語English
ページ(範囲)1479-1490
ページ数12
ジャーナルChemistry and Biodiversity
7
発行部数6
DOI
出版物ステータスPublished - 2010 6

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ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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