Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems

Dongeun Huh, Hideki Fujioka, Yi Chung Tung, Nobuyuki Futai, Robert Paine, James B. Grotberg, Shuichi Takayama

研究成果: Article査読

326 被引用数 (Scopus)

抄録

We describe a microfabricated airway system integrated with computerized air-liquid two-phase microfluidics that enables on-chip engineering of human airway epithelia and precise reproduction of physiologic or pathologic liquid plug flows found in the respiratory system. Using this device, we demonstrate cellular-level lung injury under flow conditions that cause symptoms characteristic of a wide range of pulmonary diseases. Specifically, propagation and rupture of liquid plugs that simulate surfactant-deficient reopening of closed airways lead to significant injury of small airway epithelial cells by generating deleterious fluid mechanical stresses. We also show that the explosive pressure waves produced by plug rupture enable detection of the mechanical cellular injury as crackling sounds.

本文言語English
ページ(範囲)18886-18891
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
104
48
DOI
出版ステータスPublished - 2007 11 27
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ASJC Scopus subject areas

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