Age-related changes in the numbers of mammotrophs, somatotrophs and mammosomatotrophs in the anterior pituitary gland of female rats: A flow cytometric study

Tadashi Shinkai, Yoko Sakurai, Hiroshi Ooka

研究成果: Article

15 引用 (Scopus)

抄録

Age-related changes in the numbers of mammotrophs, somatotrophs, mammosomatotrophs, and the cells of other types in the anterior pituitary of female Wistar rat were measured by flow cytometry. The mammotrophs increased with age, and the somatotrophs decreased with senescence. The mammosomatotrophs increased remarkably in senescent rats, and these cells of the rats older than 21 months were about 10 times more than those of 3, and 12-13 months old rats. This result indicates that the stability of gene expression in cell differentiation is reduced in the aging process of the anterior pituitary.

元の言語English
ページ(範囲)125-131
ページ数7
ジャーナルMechanisms of Ageing and Development
83
発行部数3
DOI
出版物ステータスPublished - 1995 9 15
外部発表Yes

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Rats
Flow cytometry
Gene expression
Aging of materials
Cells

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology
  • Biochemistry
  • Developmental Neuroscience

これを引用

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abstract = "Age-related changes in the numbers of mammotrophs, somatotrophs, mammosomatotrophs, and the cells of other types in the anterior pituitary of female Wistar rat were measured by flow cytometry. The mammotrophs increased with age, and the somatotrophs decreased with senescence. The mammosomatotrophs increased remarkably in senescent rats, and these cells of the rats older than 21 months were about 10 times more than those of 3, and 12-13 months old rats. This result indicates that the stability of gene expression in cell differentiation is reduced in the aging process of the anterior pituitary.",
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AU - Ooka, Hiroshi

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