Age-related changes in the numbers of mammotrophs, somatotrophs and mammosomatotrophs in the anterior pituitary gland of female rats: A flow cytometric study

Tadashi Shinkai, Yoko Sakurai, Hiroshi Ooka

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Age-related changes in the numbers of mammotrophs, somatotrophs, mammosomatotrophs, and the cells of other types in the anterior pituitary of female Wistar rat were measured by flow cytometry. The mammotrophs increased with age, and the somatotrophs decreased with senescence. The mammosomatotrophs increased remarkably in senescent rats, and these cells of the rats older than 21 months were about 10 times more than those of 3, and 12-13 months old rats. This result indicates that the stability of gene expression in cell differentiation is reduced in the aging process of the anterior pituitary.

本文言語English
ページ(範囲)125-131
ページ数7
ジャーナルMechanisms of Ageing and Development
83
3
DOI
出版ステータスPublished - 1995 9 15

ASJC Scopus subject areas

  • 加齢科学
  • 発生生物学

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