Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators

Keita Hamasaki, Akihiko Ueno

研究成果: Article

49 引用 (Scopus)

抜粋

Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.

元の言語English
ページ(範囲)591-594
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
11
発行部数4
DOI
出版物ステータスPublished - 2001 2 26
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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