An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-1 RRE-Rev

K. Hamasaki, M. C. Woo, A. Ueno

研究成果: Article査読

24 被引用数 (Scopus)

抄録

The binding affinities of ten aminoglycosides with RRE IIB RNA have been determined. Neamine was found as the simplest consensus unit of aminoglycoside antibiotics that bind RRE lib RNA tightly. Various aromatic ring-substituted neamines have been prepared and their binding with RRE IIB RNA was examined. Among them, pyrene-substituted neamine has shown a submicromolar level of binding with the RNA. (C) 2000 Elsevier Science Ltd.

本文言語English
ページ(範囲)8327-8332
ページ数6
ジャーナルTetrahedron Letters
41
43
DOI
出版ステータスPublished - 2000 10 21
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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