In this paper, we propose an adaptive voltage huddle-based distributed-register architecture (AVHDR architecture) that integrates dynamic multiple supply voltages and interconnection delays into high-level synthesis. Next, we propose a high-level synthesis algorithm for AVHDR architectures. Our algorithm is based on iterative improvement of scheduling/binding and floorplanning. In the iteration process, huddles, each of which abstracts modules placed close to each other, are naturally generated using floorplanning. Low-supply voltages are assigned to non-critical operations, and leakage power is cut off by turning off the power supply to the sleeping functional units. Experimental results show that our algorithm achieves 50% energy-saving compared with conventional algorithms.