Antibody-regulated neurotoxic function of cell-surface β-amyloid precursor protein

Haruka Sudo, Hong Jiang, Takashi Yasukawa, Yuichi Hashimoto, Takako Niikura, Masaoki Kawasumi, Shuji Matsuda, Yuji Takeuchi, Sadakazu Aiso, Masaaki Matsuoka, Yoshitake Murayama, Ikuo Nishimoto

研究成果: Article査読

55 被引用数 (Scopus)

抄録

APP is a transmembrane precursor of β-amyloid, and its mutations cause early-onset familial Alzheimer's disease. We report a toxic function of normal wild-type APP (wtAPP). Treatment of neuronal F11 cells, immortalized embryonic day 13 neurons, overexpressing wtAPP with anti-APP antibodies caused death. Death was not induced by antibody in parental F11 cells, Death by antibody occurred through cell-surface APP, not through secreted APP, in a pertussis toxin-sensitive manner and was typical apoptosis, not observed in primary astrocytes or glioma cells overexpressing wtAPP, but observed in primary cortical neurons. Cell-surface APP thus performs a toxic function as an extracellularly controllable regulator of neuronal death. This study provides a novel insight into the normal and pathological functions of cell-surface wtAPP.

本文言語English
ページ(範囲)708-723
ページ数16
ジャーナルMolecular and Cellular Neuroscience
16
6
DOI
出版ステータスPublished - 2000
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞および分子神経科学
  • 細胞生物学

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