Antimutagenic activity of cacao: Inhibitory effect of cacao liquor polyphenols on the mutagenic action of heterocyclic amines

M. Yamagishi, M. Natsume, A. Nagaki, T. Adachi, N. Osakabe, T. Takizawa, H. Kumon, T. Osawa

研究成果: Article査読

37 被引用数 (Scopus)

抄録

We investigated the effect of polyphenols derived from cacao liquor on the mutagenic action of heterocyclic amines (HCAs) in vitro and ex vivo. In the Ames test, the cacao liquor polyphenols showed antimutagenic effects in bacteria treated with HCA in the presence of an S-9 mixture; however, they showed less efficacy than quercetin. On the other hand, the cacao liquor polyphenols showed potent antimutagenic activity in bacteria treated with activated forms of HCA, compared with quercetin. We also evaluated the effect of these compounds on enzymatic activation of HCA. They weakly suppressed the production of activated HCA. In the host-mediated assay in mice, a method used to estimate the potential carcinogenicity of chemicals ex vivo, oral administration of the cacao liquor polyphenols, reduced the number of colonies of revertant bacteria recovered from the liver. These data suggest that the cacao liquor polyphenols have an antimutagenic effect not only in vitro, but also ex vivo.

本文言語English
ページ(範囲)5074-5078
ページ数5
ジャーナルJournal of Agricultural and Food Chemistry
48
10
DOI
出版ステータスPublished - 2000 11 7
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 農業および生物科学(全般)

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