Aortic atherosclerotic plaque detection using a multiwavelength handheld photoacoustic imaging system

Susumu Hirano, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

研究成果: Conference contribution

5 被引用数 (Scopus)

抄録

Patients affected by diseases caused by arteriosclerosis are increasing. Atherosclerosis, which is becoming an especially difficult health problem, forms plaques from lipids such as cholesterol located in walls of the aorta, cerebral artery, and coronary artery. Because lipid-rich plaques are vulnerable and because arterial rupture causes acute vascular occlusion, early detection is crucially important to prevent plaque growth and rupture. Ultrasound systems can detect plaques but cannot discriminate between vulnerable and equable plaques. To evaluate plaques non-invasively and easily, we developed a handheld photoacoustic imaging device. Its usefulness was verified in phantom experiments with a bovine aorta in which mimic plaque had been embedded. Photoacoustic images taken at wavelengths that produce high light absorbance by lipids show strong photoacoustic signals from the boundary of the mimic plaque. Results confirmed that our system can evaluate plaque properties by analysis with the photoacoustic spectrum. The effects of surrounding tissues and tissue components on plaque evaluation were investigated using a layered phantom. The mimic plaque located under a 6 mm blood layer was also evaluated. Results of these analyses demonstrate the system's usefulness.

本文言語English
ホスト出版物のタイトルPhotons Plus Ultrasound
ホスト出版物のサブタイトルImaging and Sensing 2016
編集者Alexander A. Oraevsky, Lihong V. Wang
出版社SPIE
ISBN(電子版)9781628419429
DOI
出版ステータスPublished - 2016
外部発表はい
イベントPhotons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States
継続期間: 2016 2月 142016 2月 17

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
9708
ISSN(印刷版)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2016
国/地域United States
CitySan Francisco
Period16/2/1416/2/17

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

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